Format

Send to:

Choose Destination

POLR1B polymerase (RNA) I subunit B [ Homo sapiens (human) ]

Gene ID: 84172, updated on 26-May-2016
Official Symbol
POLR1Bprovided by HGNC
Official Full Name
polymerase (RNA) I subunit Bprovided by HGNC
Primary source
HGNC:HGNC:20454
See related
Ensembl:ENSG00000125630 HPRD:06852; MIM:602000; Vega:OTTHUMG00000131314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPA2; RPA135; Rpo1-2
Summary
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
2q13
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (112541915..112577153)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113298676..113334727)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RANBP2-like and GRIP domain containing 8 Neighboring gene tubulin tyrosine ligase Neighboring gene uncharacterized LOC105373562 Neighboring gene uncharacterized LOC101927330 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 5 Neighboring gene ribosomal protein S20 pseudogene 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10816, FLJ21921, MGC131780

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonucleoside binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
nucleologenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
rRNA transcription IEA
Inferred from Electronic Annotation
more info
 
termination of RNA polymerase I transcription TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase I promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase I promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
DNA-directed RNA polymerase I subunit RPA2
Names
DNA-directed RNA polymerase I 135 kDa polypeptide
DNA-directed RNA polymerase I 135kDa polypeptide
RNA polymerase I subunit 2
polymerase (RNA) I polypeptide B
polymerase (RNA) I polypeptide B, 128kDa
NP_001131076.1
NP_001269701.1
NP_001269703.1
NP_001269705.1
NP_001269706.1
NP_001269708.1
NP_061887.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137604.2NP_001131076.1  DNA-directed RNA polymerase I subunit RPA2 isoform 2

    See identical proteins and their annotated locations for NP_001131076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AA484631, AC012442, AK022533, AK128044
    Consensus CDS
    CCDS46395.1
    UniProtKB/Swiss-Prot
    Q9H9Y6
    Related
    ENSP00000405358, OTTHUMP00000203645, ENST00000417433, OTTHUMT00000330626
    Conserved Domains (4) summary
    COG0085
    Location:351078
    RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
    cd00653
    Location:601077
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam06883
    Location:507565
    RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain
    cl19478
    Location:130319
    RNA_pol_Rpb2_1; RNA polymerase beta subunit
  2. NM_001282772.1NP_001269701.1  DNA-directed RNA polymerase I subunit RPA2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AA484631, AC012442, AK302814
    Consensus CDS
    CCDS62988.1
    UniProtKB/Swiss-Prot
    Q9H9Y6
    Related
    ENSP00000444136, ENST00000541869
    Conserved Domains (4) summary
    COG0085
    Location:731172
    RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
    cd00653
    Location:761171
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam06883
    Location:601659
    RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain
    cl19478
    Location:224413
    RNA_pol_Rpb2_1; RNA polymerase beta subunit
  3. NM_001282774.1NP_001269703.1  DNA-directed RNA polymerase I subunit RPA2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in a short frameshift in the central coding region, and also uses an alternate splice site that restores the reading frame in the remaining coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AA484631, AC012442, AK128044, BC110833
    Consensus CDS
    CCDS62989.1
    UniProtKB/Swiss-Prot
    Q9H9Y6
    Related
    ENSP00000387143, OTTHUMP00000203643, ENST00000409894, OTTHUMT00000330624
    Conserved Domains (3) summary
    COG0085
    Location:35951
    RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
    cd00653
    Location:38950
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    cl19478
    Location:186375
    RNA_pol_Rpb2_1; RNA polymerase beta subunit
  4. NM_001282776.1NP_001269705.1  DNA-directed RNA polymerase I subunit RPA2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three exons in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AA484631, AC012442, AK128044, AK301178
    Consensus CDS
    CCDS62990.1
    UniProtKB/Swiss-Prot
    Q9H9Y6
    Related
    ENSP00000437914, ENST00000537335
    Conserved Domains (4) summary
    cd00653
    Location:130922
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam06883
    Location:352410
    RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain
    cl19478
    Location:16164
    RNA_pol_Rpb2_1; RNA polymerase beta subunit
    TIGR03670
    Location:345923
    rpoB_arch; DNA-directed RNA polymerase subunit B
  5. NM_001282777.1NP_001269706.1  DNA-directed RNA polymerase I subunit RPA2 isoform 6

    See identical proteins and their annotated locations for NP_001269706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus, compared to isoform 1. Both variants 6 and 7 encode isoform 6.
    Source sequence(s)
    AA484631, AC012442, AK128044, BX647360
    UniProtKB/Swiss-Prot
    Q9H9Y6
    UniProtKB/TrEMBL
    B7Z1W6
    Conserved Domains (4) summary
    cd00653
    Location:1994
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam06883
    Location:424482
    RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain
    cl19478
    Location:47236
    RNA_pol_Rpb2_1; RNA polymerase beta subunit
    TIGR03670
    Location:417995
    rpoB_arch; DNA-directed RNA polymerase subunit B
  6. NM_001282779.1NP_001269708.1  DNA-directed RNA polymerase I subunit RPA2 isoform 6

    See identical proteins and their annotated locations for NP_001269708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus, compared to isoform 1. Both variants 6 and 7 encode isoform 6.
    Source sequence(s)
    AA484631, AC012442, AK128044, AK294027
    UniProtKB/Swiss-Prot
    Q9H9Y6
    UniProtKB/TrEMBL
    B7Z1W6
    Conserved Domains (4) summary
    cd00653
    Location:1994
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam06883
    Location:424482
    RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain
    cl19478
    Location:47236
    RNA_pol_Rpb2_1; RNA polymerase beta subunit
    TIGR03670
    Location:417995
    rpoB_arch; DNA-directed RNA polymerase subunit B
  7. NM_019014.5NP_061887.2  DNA-directed RNA polymerase I subunit RPA2 isoform 1

    See identical proteins and their annotated locations for NP_061887.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA484631, AC012442, AK128044, AK294027, BC110833
    Consensus CDS
    CCDS2097.1
    UniProtKB/Swiss-Prot
    Q9H9Y6
    UniProtKB/TrEMBL
    B7Z1W6
    Related
    ENSP00000263331, OTTHUMP00000161989, ENST00000263331, OTTHUMT00000254083
    Conserved Domains (4) summary
    COG0085
    Location:351134
    RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
    cd00653
    Location:381133
    RNA_pol_B_RPB2; RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase ...
    pfam06883
    Location:563621
    RNA_pol_Rpa2_4; RNA polymerase I, Rpa2 specific domain
    cl19478
    Location:186375
    RNA_pol_Rpb2_1; RNA polymerase beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    112541915..112577153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    113303652..113338873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)