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SERPIN1 Serine protease inhibitor (SERPIN) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841182, updated on 15-Feb-2024

Summary

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Gene symbol
SERPIN1
Gene description
Serine protease inhibitor (SERPIN) family protein
Primary source
Araport:AT1G47710
Locus tag
AT1G47710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtSERPIN1; T2E6.22
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Genomic context

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Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (17557091..17560331)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene Primosome PriB/single-strand DNA-binding protein Neighboring gene F-box and associated interaction domains-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Singlet Oxygen-Induced Membrane Disruption and Serpin-Protease Balance in Vacuolar-Driven Cell Death. Koh E, et al. Plant Physiol, 2016 Jul. PMID 26884487, Free PMC Article
  2. AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta. Lema Asqui S, et al. New Phytol, 2018 May. PMID 28157265
  3. Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis. Lampl N, et al. Plant J, 2013 May. PMID 23398119
  4. Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21). Lampl N, et al. J Biol Chem, 2010 Apr 30. PMID 20181955, Free PMC Article
  5. Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9. Vercammen D, et al. J Mol Biol, 2006 Dec 8. PMID 17028019

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtSerpin1 blocked AtMC1 self-processing and inhibited AtMC1-mediated cell death.
    Title: AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta.
  2. Serpin1 and WSCP differentially regulate the activity of RD21 during plant development in Arabidopsis thaliana.
    Title: Serpin1 and WSCP differentially regulate the activity of the cysteine protease RD21 during plant development in Arabidopsis thaliana.
  3. The GLV1 precursor is a direct subtilase substrate. The elimination of the in vitro subtilase recognition sites through alanine substitution suppressed the GLV1 gain-of-function phenotype in vivo. The protease inhibitor Serpin1 bound to SBT6.1 and inhibited the cleavage of GLV1 precursors by the protease.
    Title: The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation.
  4. Serpin1 in the cytoplasm can partially protect cells from vacuolar-mediated cell death.
    Title: Singlet Oxygen-Induced Membrane Disruption and Serpin-Protease Balance in Vacuolar-Driven Cell Death.
  5. AtSerpin1 and RD21 can modulate necrotroph-induced cell death.
    Title: Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis.
  6. AtSerpin1, which was found to be a potent inhibitor of AtMC9 activity in vitro through cleavage of its reactive center loop and covalent binding to AtMC9. [AtSerpin1]
    Title: Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_103664.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apoplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine protease inhibitor (SERPIN) family protein
NP_175202.1
  • Serine protease inhibitor (SERPIN) family protein; FUNCTIONS IN: serine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity; INVOLVED IN: biological_process unknown; LOCATED IN: apoplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protease inhibitor I4, serpin, plant (InterPro:IPR015554), Protease inhibitor I4, serpin (InterPro:IPR000215); BEST Arabidopsis thaliana protein match is: Serine protease inhibitor (SERPIN) family protein (TAIR:AT3G45220.1); Has 6643 Blast hits to 6565 proteins in 500 species: Archae - 66; Bacteria - 387; Metazoa - 5142; Fungi - 12; Plants - 353; Viruses - 463; Other Eukaryotes - 220 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    17557091..17560331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001333282.1 → NP_001320925.1  Serine protease inhibitor (SERPIN) family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8API2, A0A654EH51

  2. NM_103664.4 → NP_175202.1  Serine protease inhibitor (SERPIN) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175202.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9S7T8
    UniProtKB/TrEMBL
    A0A178W8B7, A0A5S9WMY8, A0A654EH51
    Conserved Domains (1) summary
    cd02043
    Location:8 → 389
    serpinP_plants; serpin family P, plant serpins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9S7T8.1

Gene LinkOut

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