UXT ubiquitously-expressed, prefoldin-like chaperone [Homo sapiens] - Gene

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Summary

Official Symbol: UXTprovided by HGNC
Official Full Name: ubiquitously-expressed, prefoldin-like chaperoneprovided by HGNC
Primary source: HGNC:12641
Locus tag: RP1-212G6.2
See related: Ensembl:ENSG00000126756; HPRD:02209; MIM:300234; Vega:OTTHUMG00000021453
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STAP1; ART-27
Summary: The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

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Genomic context

Location :: Xp11.23-p11.22

Sequence :: Chromosome: X; NC_000023.10 (47511195..47518560, complement)

See UXT in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction.
Title: UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria.
these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway.
Title: Alfa-class prefoldin protein UXT is a novel interacting partner of Amyotrophic Lateral Sclerosis 2 (Als2) protein.
Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes.
Title: Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.
Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation.
Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
Title: High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
propose a transcriptional regulatory circuit for the developmental expression of ART-27 that includes repression by chromatin modification through a trichostatin A-sensitive factor and activation upon growth factor stimulation via CREB
Title: Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27.
Increasing concentrations of UXT contributes to progressive aggregation of mitochondria.
Title: UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation.
UXT suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like ecotropic viral integration site 1
Title: UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation.
decreased levels of ART-27 protein in prostate cancer tissue may occur as a result of de-differentiation, and indicate that ART-27 is likely to regulate a subset of AR-responsive genes important to prostate growth suppression and differentiation.
Title: ART-27, an androgen receptor coactivator regulated in prostate development and cancer.
UXT is a component of centrosome and is essential for cell viability and may facilitate transformation by corrupting regulated centrosome functions.
Title: UXT is a novel centrosomal protein essential for cell viability.

Submit: New GeneRIF Correction See all (12)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000023.8	NP_005216.1	E2F1	BIND	PubMed	E2F1 interacts with the UXT chromatin.
NC_000023.8	NP_004082.1	E2F2	BIND	PubMed	E2F2 interacts with the UXT chromatin.
NC_000023.8	NP_001940.1	E2F3	BIND	PubMed	E2F3 interacts with the UXT chromatin.
NC_000023.8	NP_001941.2	E2F4	BIND	PubMed	E2F4 interacts with the UXT chromatin.
NC_000023.8		RBL1	BIND	PubMed	p107 interacts with the UXT chromatin.
NC_000023.8	NP_005602.2	RBL2	BIND	PubMed	p130 interacts with the UXT chromatin.
NP_004173.1	NP_005974.2	SKP2	BIND	PubMed	STAP1 interacts with SKP2.
NP_004173.1	NP_003787.2	URI1	BIND	PubMed	URI interacts with STAP1.
Q9UBK9	P10275	AR	HPRD	PubMed
Q9UBK9	Q9BXF3	CECR2	HPRD	PubMed
Q9UBK9	P42704	LRPPRC	HPRD	PubMed
Q9UBK9	O15116	LSM1	HPRD	PubMed
Q9UBK9	P53805	RCAN1	HPRD	PubMed
BioGRID:113997	BioGRID:106862	AR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:113997	BioGRID:108995	GLE1	BioGRID	PubMed	Two-hybrid
BioGRID:113997	BioGRID:115432	LRPPRC	BioGRID	PubMed	Two-hybrid
BioGRID:113997	BioGRID:118104	LSM1	BioGRID	PubMed	Two-hybrid
BioGRID:113997	BioGRID:122959	RPAP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113997	BioGRID:122783	RPAP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113997	BioGRID:116067	RUVBL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113997	BioGRID:112707	SVIL	BioGRID	PubMed	Two-hybrid
BioGRID:113997	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
RNA polymerase II transcription corepressor activity	IDA Inferred from Direct Assay more info
NOT actin filament binding	IDA Inferred from Direct Assay more info	PubMed
beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info
microtubule binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
centrosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
mitochondrion transport along microtubule	TAS Traceable Author Statement more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
protein folding	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info
cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with gamma-tubulin complex	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
prefoldin complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: protein UXT

Names: protein UXT; SKP2-associated alpha PFD 1; ubiquitously expressed transcript protein; androgen receptor trapped clone 27 protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004182.3 → NP_004173.1 protein UXT isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AF092737, BQ681820, DA372561

Consensus CDS

CCDS14285.1

UniProtKB/Swiss-Prot

Q9UBK9

Related

ENSP00000327797, OTTHUMP00000023226, ENST00000333119, OTTHUMT00000056440

Conserved Domains (1) summary

cd00584
Location:18 – 137
Blast Score: 196

Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
NM_153477.2 → NP_705582.1 protein UXT isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AF083242, BQ681820, DA372561

Consensus CDS

CCDS14284.1

UniProtKB/Swiss-Prot

Q9UBK9

Related

ENSP00000337393, OTTHUMP00000023227, ENST00000335890, OTTHUMT00000056441

Conserved Domains (1) summary

cd00584
Location:30 – 149
Blast Score: 202

Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

RNA

NR_045559.1 RNA Sequence

Description

Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF083242, BM471483, BQ681820, DA372561
NR_045560.1 RNA Sequence

Description

Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BQ681820, DA372561, EL949569

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

47511195..47518560, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

45223948..45231313, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL009172.1	CAI42447.1
		CAI42448.1
		CAI42449.1
genomic	CH471164.1	EAW59324.1
		EAW59325.1
		EAW59326.1
genomic	CQ834162.1	CAH05296.1
genomic	CQ834164.1	CAH05297.1
mRNA	AF083241.1	AAD39839.1
mRNA	AF083242.1	AAD39840.1
mRNA	AF092737.1	AAD28698.1
mRNA	AK223320.1	None
mRNA	AK312072.1	BAG35008.1
mRNA	BC000720.1	AAH00720.1
mRNA	BC008890.1	AAH08890.1
mRNA	BM471483.1	None
mRNA	BQ681820.1	None
mRNA	DA372561.1	None
mRNA	EL949569.1	None