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    C3orf20 chromosome 3 open reading frame 20 [ Homo sapiens (human) ]

    Gene ID: 84077, updated on 9-Jun-2013
    Official Symbol
    C3orf20provided by HGNC
    Official Full Name
    chromosome 3 open reading frame 20provided by HGNC
    Primary source
    HGNC:25320
    See related
    Ensembl:ENSG00000131379; HPRD:12821; Vega:OTTHUMG00000155545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Location :
    3p25.1
    Sequence :
    Chromosome: 3; NC_000003.11 (14716606..14814543)
    See C3orf20 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene rhomboid 5 homolog 1 (Drosophila) pseudogene 1 Neighboring gene coiled-coil domain containing 174 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene FGD5 antisense RNA 1 Neighboring gene nuclear receptor subfamily 2, group C, member 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049.
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    3. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    5. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:123872 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 

    Markers

    Genotypes

    Homology

    Clone Names

    • DKFZp434N1817

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    uncharacterized protein C3orf20
    Names
    uncharacterized protein C3orf20

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184957.1 → NP_001171886.1  uncharacterized protein C3orf20 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC090957, AL136781, BC038406, DB064418
      Consensus CDS
      CCDS54555.1
      UniProtKB/Swiss-Prot
      Q8ND61
      Related
      ENSP00000396081, OTTHUMP00000208216, ENST00000412910, OTTHUMT00000340589

    2. NM_001184958.1 → NP_001171887.1  uncharacterized protein C3orf20 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC090957, BC030599, BC038406, BG718869, DB064418
      Consensus CDS
      CCDS54555.1
      UniProtKB/Swiss-Prot
      Q8ND61
      Related
      ENSP00000402933, OTTHUMP00000208215, ENST00000435614, OTTHUMT00000340588

    3. NM_032137.4 → NP_115513.4  uncharacterized protein C3orf20 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090957, BC038406, DB064418
      Consensus CDS
      CCDS33706.1
      UniProtKB/Swiss-Prot
      Q8ND61
      Related
      ENSP00000253697, OTTHUMP00000208214, ENST00000253697, OTTHUMT00000340586

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p10 Primary Assembly

      Range
      14716606..14814543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      14652380..14750266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018914.1 Alternate CHM1_1.0

      Range
      14652017..14749984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01025153.1 (16043..28167) None
    genomic ABBA01025154.1 None
    genomic AC090957.1 (40109..137996) None
    genomic AMYH01012996.1 (794744..858408) None
    genomic AMYH01012997.1 None
    genomic CH471055.1 EAW64204.1
      EAW64205.1
      EAW64206.1
    mRNA AK131481.1 None
    mRNA AL136781.1 CAB66715.1
    mRNA AL834386.1 CAD39049.1
    mRNA BC030599.2 AAH30599.1
    mRNA BC038406.1 AAH38406.2
    mRNA BG718869.1 None
    mRNA DB064418.1 None
    other-genetic AM392830.1 CAL37708.1
    other-genetic AM392982.1 CAL37860.1
    other-genetic AM393237.1 CAL38115.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ND61.2 GenPept UniProtKB/Swiss-Prot:Q8ND61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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