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    SPARCL1 SPARC-like 1 (hevin) [ Homo sapiens (human) ]

    Gene ID: 8404, updated on 5-May-2013
    Official Symbol
    SPARCL1provided by HGNC
    Official Full Name
    SPARC-like 1 (hevin)provided by HGNC
    Primary source
    HGNC:11220
    See related
    Ensembl:ENSG00000152583; HPRD:06919; MIM:606041; Vega:OTTHUMG00000130605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SC1; PIG33
    Location :
    4q22.1
    Sequence :
    Chromosome: 4; NC_000004.11 (88394487..88450655, complement)
    See SPARCL1 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L19 pseudogene Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 9 Neighboring gene dentin sialophosphoprotein Neighboring gene dentin matrix acidic phosphoprotein 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome. Hurley PJ, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927397.
    2. Sparc-like protein 1 is a new marker of human glioma progression. Turtoi A, et al. J Proteome Res, 2012 Oct 5. PMID 22909274.
    3. Secreted protein acidic and rich in cysteines-like 1 suppresses aggressiveness and predicts better survival in colorectal cancers. Hu H, et al. Clin Cancer Res, 2012 Oct 1. PMID 22891198.
    4. Down-regulated SPARCL1 is associated with clinical significance in human gastric cancer. Li P, et al. J Surg Oncol, 2012 Jan. PMID 22161898.
    5. SPARCL1: a potential molecule associated with tumor diagnosis, progression and prognosis of colorectal cancer. Zhang H, et al. Tumour Biol, 2011 Dec. PMID 21887554.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. SPARCL1 functions as a tumor suppressor promoting differentiation possibly via MET, which inhibits the aggressiveness of colorectal cancers
      Title: Secreted protein acidic and rich in cysteines-like 1 suppresses aggressiveness and predicts better survival in colorectal cancers.
    2. Sparc-like protein 1 expression correlates with glioma grade, suggesting the possible role for this protein in the progression of this malignancy.
      Title: Sparc-like protein 1 is a new marker of human glioma progression.
    3. SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence.
      Title: Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome.
    4. Data suggest that the expression of SPARCL1 protein might be a valuable biomarker for early diagnosis in colorectal cancers and further predicting patients' prognosis.
      Title: SPARCL1: a potential molecule associated with tumor diagnosis, progression and prognosis of colorectal cancer.
    5. Down-regulated SPARCL1 is associated with gastric cancer.
      Title: Down-regulated SPARCL1 is associated with clinical significance in human gastric cancer.
    6. Data suggest that SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in colorectal cancer.
      Title: SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer.
    7. A transgenic mouse model in which SPARCL1 is expressed in radial glia provides a novel in vivo system for evaluating the role of SPARCL1 in brain development and function.
      Title: A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    9. Despite proteomic studies in CSF from MS patients suggested an important role for SPARCL1 in the development of the disease, SPARCL1 gene does not appear to act as susceptibility factor for MS in the population investigated here.
      Title: Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis.
    10. Overall, these results suggested that the C-t of hevin contains important determinants for interaction with myocilin.
      Title: Interaction of myocilin with the C-terminal region of hevin.
    Submit: New GeneRIF Correction See all (11)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q14515 P04156 PRNP    HPRD  PubMed  
    Q14515 P12757 SKIL    HPRD  PubMed  
    BioGRID:113992 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113992 BioGRID:108276 EGFR    BioGRID  PubMed PCA 
    BioGRID:113992 BioGRID:112389 SKIL    BioGRID  PubMed Two-hybrid 
    BioGRID:113992 BioGRID:113164 UBC    BioGRID  PubMed Reconstituted Complex 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    SPARC-like protein 1
    Names
    SPARC-like protein 1
    hevin
    mast9
    MAST 9
    SPARC-like 1 (mast9, hevin)
    high endothelial venule protein
    proliferation-inducing protein 33

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128310.1 → NP_001121782.1  SPARC-like protein 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC022484, DC403565, DC421365, X86693
      Consensus CDS
      CCDS3622.1
      UniProtKB/Swiss-Prot
      Q14515
      Related
      ENSP00000414856, ENST00000418378
      Conserved Domains (3) summary
      cd00252
      Location:514 – 662
      Blast Score: 336
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:513 – 650
      Blast Score: 414
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
      cl00097
      Location:433 – 512
      Blast Score: 228
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    2. NM_004684.4 → NP_004675.3  SPARC-like protein 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC022484, DC403565, X86693
      Consensus CDS
      CCDS3622.1
      UniProtKB/Swiss-Prot
      Q14515
      Related
      ENSP00000282470, OTTHUMP00000161184, ENST00000282470, OTTHUMT00000253059
      Conserved Domains (3) summary
      cd00252
      Location:514 – 662
      Blast Score: 336
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:513 – 650
      Blast Score: 414
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
      cl00097
      Location:433 – 512
      Blast Score: 228
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p10 Primary Assembly

      Range
      88394487..88450655, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      84140423..84196598, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018915.1 Alternate CHM1_1.0

      Range
      88202773..88258933, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01063536.1 (35927..92102) None
    genomic AC093906.3 None
    genomic AC112250.4 (65142..77475) None
    genomic AMYH01014379.1 (120380..176540) None
    genomic CH471057.1 EAX05991.1
      EAX05992.1
    mRNA AK294335.1 BAG57605.1
    mRNA AK298039.1 BAG60338.1
    mRNA AK300956.1 BAG62584.1
    mRNA AK304494.1 BAG65302.1
    mRNA AK304628.1 BAG65409.1
    mRNA AK316533.1 BAH14904.1
    mRNA AL833430.1 None
    mRNA AY513278.1 AAT08031.1
    mRNA BC010383.1 None
    mRNA BC022484.1 None
    mRNA BC033721.1 AAH33721.1
    mRNA BX647713.1 None
    mRNA DC403565.1 None
    mRNA DC421365.1 None
    mRNA X82157.1 CAA57650.1
    mRNA X86693.1 CAA60386.1
    other-genetic EU832833.1 ACE87844.1
    other-genetic GQ129224.1 ACT64358.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14515.2 GenPept UniProtKB/Swiss-Prot:Q14515

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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