Display Settings:

Format

Send to:

Choose Destination

SPARCL1 SPARC-like 1 (hevin) [ Homo sapiens (human) ]

Gene ID: 8404, updated on 5-Jul-2015
Official Symbol
SPARCL1provided by HGNC
Official Full Name
SPARC-like 1 (hevin)provided by HGNC
Primary source
HGNC:HGNC:11220
See related
Ensembl:ENSG00000152583; HPRD:06919; MIM:606041; Vega:OTTHUMG00000130605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SC1; MAST9; PIG33; MAST 9
Orthologs
See SPARCL1 in Epigenomics, MapViewer
Location:
4q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (87473330..87529503, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88394483..88450798, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929090 Neighboring gene uncharacterized LOC105377321 Neighboring gene uncharacterized LOC105377322 Neighboring gene dentin sialophosphoprotein Neighboring gene uncharacterized LOC105377323 Neighboring gene dentin matrix acidic phosphoprotein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SPARC-like protein 1
Names
high endothelial venule protein
proliferation-inducing protein 33

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128310.2NP_001121782.1  SPARC-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001121782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC022484, CA442598, DC403565, DC421365, X86693
    Consensus CDS
    CCDS3622.1
    UniProtKB/TrEMBL
    A0A024RDE1
    UniProtKB/Swiss-Prot
    Q14515
    Related
    ENSP00000414856, ENST00000418378
    Conserved Domains (3) summary
    cd00252
    Location:514662
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam07423
    Location:232299
    DUF1510; Protein of unknown function (DUF1510)
    cl00097
    Location:433512
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
  2. NM_001291976.1NP_001278905.1  SPARC-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001278905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK316533, AL833430, CA442598, DA283085, DC403565, X86693
    Consensus CDS
    CCDS77939.1
    UniProtKB/TrEMBL
    B7ZB68
    UniProtKB/Swiss-Prot
    Q14515
    Related
    ENSP00000422903, OTTHUMP00000219654, ENST00000503414, OTTHUMT00000363611
    Conserved Domains (3) summary
    cd00252
    Location:389537
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam07423
    Location:107174
    DUF1510; Protein of unknown function (DUF1510)
    cl00097
    Location:308387
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
  3. NM_001291977.1NP_001278906.1  SPARC-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001278906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK304494, CA442598, DC403565, X86693
    Consensus CDS
    CCDS77939.1
    UniProtKB/Swiss-Prot
    Q14515
    Conserved Domains (3) summary
    cd00252
    Location:389537
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam07423
    Location:107174
    DUF1510; Protein of unknown function (DUF1510)
    cl00097
    Location:308387
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
  4. NM_004684.5NP_004675.3  SPARC-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004675.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK304494, BC022484, BC033721, CA442598, DA283085, DC403565, X86693
    Consensus CDS
    CCDS3622.1
    UniProtKB/TrEMBL
    A0A024RDE1
    UniProtKB/Swiss-Prot
    Q14515
    UniProtKB/TrEMBL
    Q8N4S1
    Related
    ENSP00000282470, OTTHUMP00000161184, ENST00000282470, OTTHUMT00000253059
    Conserved Domains (3) summary
    cd00252
    Location:514662
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam07423
    Location:232299
    DUF1510; Protein of unknown function (DUF1510)
    cl00097
    Location:433512
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    87473330..87529503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    88371311..88427455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)