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SPARCL1 SPARC-like 1 (hevin) [ Homo sapiens (human) ]

Gene ID: 8404, updated on 12-Apr-2014
Official Symbol
SPARCL1provided by HGNC
Official Full Name
SPARC-like 1 (hevin)provided by HGNC
Primary source
HGNC:11220
See related
Ensembl:ENSG00000152583; HPRD:06919; MIM:606041; Vega:OTTHUMG00000130605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SC1; PIG33
Location :
4q22.1
Sequence :
Chromosome: 4; NC_000004.12 (87473335..87529503, complement)
See SPARCL1 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 9 Neighboring gene uncharacterized LOC101929090 Neighboring gene uncharacterized LOC102723404 Neighboring gene dentin sialophosphoprotein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SPARC-like protein 1
Names
SPARC-like protein 1
hevin
mast9
MAST 9
SPARC-like 1 (mast9, hevin)
high endothelial venule protein
proliferation-inducing protein 33

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128310.1NP_001121782.1  SPARC-like protein 1 precursor

    See proteins identical to NP_001121782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC022484, DC403565, DC421365, X86693
    Consensus CDS
    CCDS3622.1
    UniProtKB/Swiss-Prot
    Q14515
    Related
    ENSP00000414856, ENST00000418378
    Conserved Domains (3) summary
    cd00252
    Location:514662
    Blast Score: 384
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam07423
    Location:232299
    Blast Score: 86
    DUF1510; Protein of unknown function (DUF1510)
    cl00097
    Location:433512
    Blast Score: 255
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
  2. NM_004684.4NP_004675.3  SPARC-like protein 1 precursor

    See proteins identical to NP_004675.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC022484, DC403565, X86693
    Consensus CDS
    CCDS3622.1
    UniProtKB/Swiss-Prot
    Q14515
    Related
    ENSP00000282470, OTTHUMP00000161184, ENST00000282470, OTTHUMT00000253059
    Conserved Domains (3) summary
    cd00252
    Location:514662
    Blast Score: 384
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam07423
    Location:232299
    Blast Score: 86
    DUF1510; Protein of unknown function (DUF1510)
    cl00097
    Location:433512
    Blast Score: 255
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38 Primary Assembly

    Range
    87473335..87529503, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 Alternate HuRef

    Range
    84140423..84196598, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    88371316..88427455, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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