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    CASP7 caspase 7, apoptosis-related cysteine peptidase [ Homo sapiens ]

    Gene ID: 840, updated on 19-May-2012
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    Summary

    Official Symbol
    CASP7provided by HGNC
    Official Full Name
    caspase 7, apoptosis-related cysteine peptidaseprovided by HGNC
    Primary source
    HGNC:1508
    Locus tag
    RP11-211N11.6
    See related
    Ensembl:ENSG00000165806; HPRD:03457; MIM:601761; Vega:OTTHUMG00000019076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCH3; CMH-1; ICE-LAP3
    Summary
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    10q25
    Sequence :
    Chromosome: 10; NC_000010.10 (115438935..115490664)
    See CASP7 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene transcription factor 7-like 2 (T-cell specific, HMG-box) Neighboring gene ribosomal protein S15a pseudogene 30 Neighboring gene hyaluronan binding protein 2 Neighboring gene nebulin-related anchoring protein Neighboring gene chromosome 10 open reading frame 81 Neighboring gene microRNA 4483 Neighboring gene DNA cross-link repair 1A

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis. Riman S, et al. Mol Cell Biol, 2012 Feb. PMID 22184066.
    2. The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate. Soares J, et al. Biochemistry, 2011 Oct 25. PMID 21936563.
    3. Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. Li X, et al. J Biol Chem, 2011 Jun 24. PMID 21555521.
    4. Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7. Kenig S, et al. Apoptosis, 2011 Jul. PMID 21484410.
    5. Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. Edelmann B, et al. EMBO J, 2011 Jan 19. PMID 21157428.

    See all (158) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. identify serine 118 in the transactivation domain of YY1 as the site of CK2alpha phosphorylation, proximal to a caspase 7 cleavage site
      Title: Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.
    2. Caspase-7 cleaves human TERT at residues E286 and D628 as part of the apoptosis pathway in cultured cells.
      Title: The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate.
    3. Cathepsin L is present in the nucleus and regulates the transcription of effector caspases 3 and 7, in a p53 dependent manner.
      Title: Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7.
    4. highly expressed PAK2 mediates chemotherapeutic resistance in human breast invasive ductal carcinoma by negatively regulating caspase-7 activity
      Title: Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.
    5. The RIPK1 and CASP7 polymorphisms can be considered as possible prognostic markers for survival after curative resection in patients with colorectal cancer.
      Title: RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection.
    6. Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells
      Title: The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells.
    7. Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
      Title: Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
    8. Single Nucleotide Polymorphisms in CASP7 is asspciated with lung cancer.
      Title: Polymorphisms in the caspase genes and the risk of lung cancer.
    9. Human caspase-3 and -7 exhibit differences in protease activity, specific homodimer-forming activity, and three-dimensional structural features, all of which are closely interrelated.
      Title: Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells.
    10. Data show that sorafenib initiated lethal apoptotic process through the release of cytochrome c and caspase 3/7 activation.
      Title: Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant Hep G2 cells through a mitochondria-dependent oxidative stress mechanism.
    Submit: New GeneRIF Correction See all (55)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001218.1 NP_000035.2 AR    BIND  PubMed Androgen Receptor interacts with caspase 7. 
    NP_001218.1 NP_001931.1 ATN1    BIND  PubMed Atrophin-1 interacts with caspase 7. 
    NP_001218.1 NP_001156.1 BIRC3    BIND  PubMed cIAP2 exhibits E3 ubiquitin ligase activity towards Casp7. 
    NP_203125.1 NP_001902.1 CTSG    BIND  PubMed CatG interacts with caspase-7. 
    NP_203125.1 NP_004122.1 GZMB    BIND  PubMed GraB interacts with caspase-7. 
    NP_203125.1 NP_002102.2 HTT    BIND  PubMed Htt interacts with caspase 7. 
    NP_203125.1 NP_001609.1 PARP1    BIND  PubMed PARP interacts with caspase-7. This interaction was modelled on a demonstrated interaction between human PARP and fly drICE. 
    NP_203125.1 NP_015557.1 PSEN1    BIND  PubMed PS1 interacts with caspase 7. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 7. 
    NP_203125.1 NP_000312.1 RB1    BIND  PubMed CASP7 (caspase-7) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p68, p61 and p48 forms. 
    NP_203125.1 NP_001158.2 XIAP    BIND  PubMed Caspase-7 interacts with XIAP. 
    NP_203125.1     BIND  PubMed Caspase-7 interacts with and hydrolyzes Ac-DEVD-afc. 
    P55210 P10275 AR    HPRD  PubMed  
    P55210 Q13490 BIRC2    HPRD  PubMed  
    P55210 Q13489 BIRC3    HPRD  PubMed  
    P55210 O15392 BIRC5    HPRD  PubMed  
    P55210 Q96CA5 BIRC7    HPRD  PubMed  
    P55210 Q92851 CASP10    HPRD  PubMed  
    P55210 P42575 CASP2    HPRD  PubMed  
    P55210 P55210 CASP7    HPRD  PubMed  
    P55210 P20810 CAST    HPRD  PubMed  
    P55210 P60953 CDC42    HPRD  PubMed  
    P55210 O15519 CFLAR    HPRD  PubMed  
    P55210 Q9HAW4 CLSPN    HPRD  PubMed  
    P55210 P08311 CTSG    HPRD  PubMed  
    P55210 Q14203 DCTN1    HPRD  PubMed  
    P55210 O00273 DFFA    HPRD  PubMed  
    P55210 P15924 DSP    HPRD  PubMed  
    P55210 P19525 EIF2AK2    HPRD  PubMed  
    P55210 Q08378 GOLGA3    HPRD  PubMed  
    P55210 Q9BQQ3 GORASP1    HPRD  PubMed  
    P55210 P10144 GZMB    HPRD  PubMed  
    P55210 P11021 HSPA5    HPRD  PubMed  
    P55210 P05783 KRT18    HPRD  PubMed  
    P55210 P07948 LYN    HPRD  PubMed  
    P55210 P10636 MAPT    HPRD  PubMed  
    P55210 P61244 MAX    HPRD  PubMed  
    P55210 Q02078 MEF2A    HPRD  PubMed  
    P55210 Q14814 MEF2D    HPRD  PubMed  
    P55210 P46934 NEDD4    HPRD  PubMed  
    P55210 Q05513 PRKCZ    HPRD  PubMed  
    P55210 P49768 PSEN1    HPRD  PubMed  
    P55210 P49810 PSEN2    HPRD  PubMed  
    P55210 O75475 PSIP1    HPRD  PubMed  
    P55210 P61289 PSME3    HPRD  PubMed  
    P55210 P06454 PTMA    HPRD  PubMed  
    P55210 P63000 RAC1    HPRD  PubMed  
    P55210 O60216 RAD21    HPRD  PubMed  
    P55210 Q06609 RAD51    HPRD  PubMed  
    P55210 P20936 RASA1    HPRD  PubMed  
    P55210 P06400 RB1    HPRD  PubMed  
    P55210 Q9UBF6 RNF7    HPRD  PubMed  
    P55210 P11831 SRF    HPRD  PubMed  
    P55210 Q9Y6E0 STK24    HPRD  PubMed  
    P55210 P19438 TNFRSF1A    HPRD  PubMed  
    P55210 O95155 UBE4B    HPRD  PubMed  
    P55210 P08670 VIM    HPRD  PubMed  
    P55210 P98170 XIAP    HPRD  PubMed  
    NP_001157.1 BIRC2    BIND  PubMed c-IAP1 interacts with caspase-7. 
    BioGRID:107290 BioGRID:106826 BIRC2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107290 BioGRID:106827 BIRC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107290 BioGRID:106829 BIRC5    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    NP_057336.1 BIRC6    BIND  PubMed BRUCE interacts with Casp-7. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-7. 
    BioGRID:107290 BioGRID:122670 BIRC7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107290 BioGRID:107293 CASP10    BioGRID  PubMed Biochemical Activity 
    BioGRID:107290 BioGRID:107285 CASP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107290 BioGRID:107291 CASP8    BioGRID  PubMed Biochemical Activity 
    BioGRID:107290 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107290 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Biochemical Activity 
    BioGRID:107290 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    NP_001158.2 XIAP    BIND  PubMed XIAP interacts with caspase-7. 
    NP_001158.2 XIAP    BIND  PubMed XIAP interacts with Casp-7. 
    BioGRID:107290 BioGRID:106828 XIAP    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem (from REACTOME)
      Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystemProcaspase-3 and 7 are cleaved by the apoptosome.
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation by HSP70, organism-specific biosystem
      Apoptosis Modulation by HSP70
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Apoptotic factor-mediated response, organism-specific biosystem (from REACTOME)
      Apoptotic factor-mediated response, organism-specific biosystemIn response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome form...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
      Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemCaspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and ...
    • Cytochrome c-mediated apoptotic response, organism-specific biosystem (from REACTOME)
      Cytochrome c-mediated apoptotic response, organism-specific biosystemUpon its release from the mitochondrial intermembrane space, Cytochrome c binds to and causes a conformational change in the cytoplasmic protein Apaf1. This conformational change allows the Cytochrom...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • SMAC binds to IAPs, organism-specific biosystem (from REACTOME)
      SMAC binds to IAPs, organism-specific biosystemSMAC binds to the XIAP:caspase complexes.
    • SMAC-mediated apoptotic response, organism-specific biosystem (from REACTOME)
      SMAC-mediated apoptotic response, organism-specific biosystemOnce released from the mitochondria, SMAC binds to IAP family proteins displacing them from Caspase:IAP complexes liberating the active caspases.
    • SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystem (from REACTOME)
      SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystemSmac/DIABLO regulates IAP function. Residues 56â??59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • a6b1 and a6b4 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      a6b1 and a6b4 Integrin signaling, organism-specific biosystem
      a6b1 and a6b4 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    cysteine-type peptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c TAS
    Traceable Author Statement
    more info
    		  
    aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of neuron apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    microsome IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    caspase-7
    Names
    caspase-7
    CASP-7
    Lice2 alpha/beta/gamma
    caspase 7 isoform delta
    apoptotic protease MCH-3
    ICE-like apoptotic protease 3
    caspase 7, apoptosis-related cysteine protease
    NP_001218.1
    NP_203124.1
    NP_203125.1
    NP_203126.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001227.3 → NP_001218.1  caspase-7 isoform alpha precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) lacks a segment in the coding region and uses a downstream in-frame start codon, compared to variant delta. Variant alpha encodes isoform alpha which has a shorter N-terminus, compared to isoform delta.
      Source sequence(s)
      AL627395, AU130224, BQ007179, U37448, U67206
      Consensus CDS
      CCDS7581.1
      UniProtKB/Swiss-Prot
      P55210
      Related
      ENSP00000358324, OTTHUMP00000020510, ENST00000369318, OTTHUMT00000050435
      Conserved Domains (1) summary
      cd00032
      Location:60 – 301
      Blast Score: 782
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    2. NM_033338.4 → NP_203124.1  caspase-7 isoform delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (delta), also called alpha', encodes the longest isoform (delta).
      Source sequence(s)
      AL627395, BQ007179, U37448, U67319
      Consensus CDS
      CCDS7580.1
      UniProtKB/Swiss-Prot
      P55210
      Related
      ENSP00000358327, ENST00000369321
      Conserved Domains (1) summary
      cd00032
      Location:93 – 334
      Blast Score: 787
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    3. NM_033339.3 → NP_203125.1  caspase-7 isoform alpha

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma) differs in the 5' UTR, lacks a segment in the 5' coding region, and uses a downstream in-frame start codon, compared to variant delta. Variant gamma encodes isoform alpha, which is shorter than isoform delta.
      Source sequence(s)
      AL627395, BQ007179, U37448, U67206
      Consensus CDS
      CCDS7581.1
      UniProtKB/Swiss-Prot
      P55210
      Related
      ENSP00000298701, OTTHUMP00000020514, ENST00000345633, OTTHUMT00000050439
      Conserved Domains (1) summary
      cd00032
      Location:60 – 301
      Blast Score: 782
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    4. NM_033340.2 → NP_203126.1  caspase-7 isoform beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) has multiple differences in the 5' UTR and coding region, and uses a downstream in-frame start codon, compared to variant delta. Variant beta encodes isoform beta which has a distinct C-terminus, compared to isoform delta.
      Source sequence(s)
      BP429646, BQ007179, BX487250, U37449
      Consensus CDS
      CCDS7582.1
      UniProtKB/Swiss-Prot
      P55210
      Related
      ENSP00000358337, OTTHUMP00000020512, ENST00000369331, OTTHUMT00000050437
      Conserved Domains (1) summary
      cl00042
      Location:60 – 164
      Blast Score: 288
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      115438935..115490664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      109065817..109118483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL592546.7 CAI12638.1
      CAI12639.1
      CAI12640.1
    genomic AL627395.14 CAI16004.1
      CAI16005.1
      CAI16006.1
    genomic CH471066.2 EAW49494.1
      EAW49495.1
      EAW49496.1
      EAW49497.1
      EAW49498.1
    genomic GM887522.1 CAV28504.1
    mRNA AB451281.1 BAG70095.1
    mRNA AB451413.1 BAG70227.1
    mRNA AK223489.1 None
    mRNA AK298964.1 BAG61059.1
    mRNA AK300578.1 BAG62277.1
    mRNA AK301437.1 BAG62964.1
    mRNA AU130224.1 None
    mRNA BC015799.1 AAH15799.1
    mRNA BP429646.1 None
    mRNA BQ007179.1 None
    mRNA BT006683.1 AAP35329.1
    mRNA BX487250.1 None
    mRNA BX647973.1 None
    mRNA U37448.1 AAC50303.1
    mRNA U37449.1 AAC50304.1
    mRNA U39613.1 AAC50346.1
    mRNA U40281.1 AAC50352.1
    mRNA U67206.1 AAF21460.1
    mRNA U67320.1 AAC51153.1
    other-genetic DQ890614.2 ABM92231.1
    other-genetic DQ893769.2 ABM84695.1
    other-genetic EU831939.1 ACE87380.1
    other-genetic EU832034.1 ACE86696.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55210.1 GenPept UniProtKB/Swiss-Prot:P55210
    Q5SVL2 GenPept UniProtKB/TrEMBL:Q5SVL2
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