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    CTTNBP2 cortactin binding protein 2 [ Homo sapiens ]

    Gene ID: 83992, updated on 11-May-2012

    Summary

    Official Symbol
    CTTNBP2provided by HGNC
    Official Full Name
    cortactin binding protein 2provided by HGNC
    Primary source
    HGNC:15679
    See related
    Ensembl:ENSG00000077063; HPRD:09890; MIM:609772; Vega:OTTHUMG00000022880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Orf4; C7orf8; CORTBP2; FLJ34229; KIAA1758; MGC104579
    Summary
    This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    7q31
    Sequence :
    Chromosome: 7; NC_000007.13 (117350705..117513561, complement)
    See CTTNBP2 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 49 pseudogene Neighboring gene cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene ankyrin repeat domain 7

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8WZ74 Q14247 CTTN    HPRD  PubMed  
    BioGRID:123842 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:113054 CCT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:107346 CCT6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:115933 CCT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:121000 CTTNBP2NL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:124497 FAM40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:121534 FAM40B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:117369 MOB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:119722 MST4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:116400 PDCD10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:114011 STK24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:112674 STRN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:118999 STRN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:118941 STRN4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123842 BioGRID:120139 ZRANB1    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cortactin-binding protein 2
    Names
    cortactin-binding protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033427.2NP_219499.1  cortactin-binding protein 2

      Status: REVIEWED

      Source sequence(s)
      AF377960, BC019644
      Consensus CDS
      CCDS5774.1
      UniProtKB/TrEMBL
      Q20BG9
      UniProtKB/Swiss-Prot
      Q8WZ74
      Related
      ENSP00000160373, OTTHUMP00000024498, ENST00000160373, OTTHUMT00000059201
      Conserved Domains (4) summary
      cd00204
      Location:738863
      Blast Score: 336
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam09727
      Location:28181
      Blast Score: 618
      CortBP2; Cortactin-binding protein-2
      TIGR02168
      Location:127271
      Blast Score: 121
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12796
      Location:748839
      Blast Score: 265
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      117350705..117513561, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      111716178..111879317, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      116746141..116908979, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004240.1 AAC04501.2
    genomic AC007568.1 None
    genomic CH236947.1 EAL24352.1
    genomic CH471070.1 EAW83532.1
      EAW83533.1
    genomic DQ354388.1 ABC79049.1
    genomic DQ354389.1 ABC79051.1
    genomic DQ354390.1 ABC79053.1
    genomic DQ354391.1 ABC79055.1
    genomic DQ356257.1 ABC87052.1
    genomic DQ356258.1 ABC87054.1
    genomic DQ356259.1 ABC87056.1
    genomic DQ356260.1 ABC87058.1
    genomic DQ356261.1 ABC87060.1
    genomic DQ356262.1 ABC87062.1
    genomic DQ356263.1 ABC87064.1
    genomic DQ356264.1 ABC87066.1
    genomic DQ388128.1 ABD72182.1
    genomic DQ388129.1 ABD72184.1
    genomic DQ388130.1 ABD72186.1
    genomic DQ388131.1 ABD72188.1
    genomic DQ388132.1 ABD72190.1
    genomic DQ388133.1 ABD72192.1
    genomic DQ388134.1 ABD72194.1
    genomic DQ388135.1 ABD72196.1
    genomic DQ388136.1 ABD72198.1
    genomic DQ388137.1 ABD72200.1
    genomic DQ388138.1 ABD72202.1
    genomic DQ388139.1 ABD72204.1
    genomic DQ388140.1 ABD72206.1
    genomic DQ388141.1 ABD72208.1
    genomic DQ388142.1 ABD72210.1
    genomic DQ388143.1 ABD72212.1
    genomic DQ388144.1 ABD72214.1
    genomic DQ388145.1 ABD72216.1
    mRNA AB051545.1 BAB21849.1
    mRNA AF377960.1 AAL32176.1
    mRNA AK091548.1 None
    mRNA AK096565.1 BAC04818.1
    mRNA AK308081.1 None
    mRNA AL137685.1 None
    mRNA BC019644.1 None
    mRNA BC106000.1 AAI06001.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20BG7 GenPept UniProtKB/TrEMBL:Q20BG7
    Q20BG9 GenPept UniProtKB/TrEMBL:Q20BG9
    Q20BI7 GenPept UniProtKB/TrEMBL:Q20BI7
    Q2I096 GenPept UniProtKB/TrEMBL:Q2I096
    Q2I0A6 GenPept UniProtKB/TrEMBL:Q2I0A6
    Q8N8L8 GenPept UniProtKB/TrEMBL:Q8N8L8
    Q8WZ74.1 GenPept UniProtKB/Swiss-Prot:Q8WZ74

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