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    PLA2G10 phospholipase A2, group X [ Homo sapiens ]

    Gene ID: 8399, updated on 12-Dec-2011
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    Summary

    Official Symbol
    PLA2G10provided by HGNC
    Official Full Name
    phospholipase A2, group Xprovided by HGNC
    Primary source
    HGNC:9029
    See related
    Ensembl:ENSG00000069764; HPRD:04674; MIM:603603; Vega:OTTHUMG00000048069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPLA2; GXPLA2; GXSPLA2
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    Genomic context

    Location :
    16p13.1-p12
    Sequence :
    Chromosome: 16; NC_000016.9 (14766405..14788526, complement)
    See PLA2G10 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene poly(A)-specific ribonuclease Neighboring gene bifunctional apoptosis regulator Neighboring gene nuclear pore complex-interacting protein-like 1-like Neighboring gene group 10 secretory phospholipase A2-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells. Jemel I, et al. J Biol Chem, 2011 Oct 21. PMID 21878635.
    2. Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity. Hallstrand TS, et al. Clin Exp Allergy, 2011 Jun. PMID 21255140.
    3. Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X. Lai Y, et al. J Biol Chem, 2010 Dec 31. PMID 20974857.
    4. Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Zack M, et al. Atherosclerosis, 2011 Jan. PMID 20833395.
    5. Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. Granata F, et al. J Immunol, 2010 May 1. PMID 20357262.

    See all (32) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells
      Title: Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.
    2. sPLA(2) -IIA and sPLA(2) -X are the major sPLA(2) s in human airways, and suggest a link between the levels of sPLA(2) -X in the airways and several features of asthma.
      Title: Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity.
    3. GX sPLA(2) promotes Ang II-induced pathological responses leading to abdominal aortic aneurysm formation
      Title: Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice.
    4. Eosinophil cysteinyl leukotriene synthesis is mediated by exogenous secreted phospholipase A2 group X
      Title: Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.
    5. Group X secreted phospholipase A2 induces production of VEGF-A and VEGF-C from lung macrophages by a receptor-mediated, catalytically independent mechanism and may play an important role in inflammatory and neoplastic angiogenesis and lymphangiogenesis.
      Title: Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2.
    6. The T-512C polymorphism located in the 5' untranslated region of the secreted phospholipase A2 group X gene associated with a decreased risk of recurrent cardiovascular events during follow-up.
      Title: Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease.
    7. rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion
      Title: Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s.
    8. secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology
      Title: Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.
    9. Recombinant hGX sPLA2 can efficiently hydrolyze PAF unlike the others secreted PLA2s; thus hGX sPLA2 may be a novel player in PAF regulation during inflammatory processes.
      Title: The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
    Submit: New GeneRIF Correction See all (19)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env sPLA(2)-X neutralizes human immunodeficiency virus type 1 (HIV-1) through degradation of the viral membrane (gp120) and inhibits the replication of both CCR5- and CXCR4-tropic HIV-1 in human CD4(+) T cells PubMed
    env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O15496 Q9HD67 MYO10    HPRD  PubMed  
    O15496 Phospholipase A2 receptor 1 PLA2R1    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
      Arachidonic acid metabolism, organism-specific biosystem
      Arachidonic acid metabolism
    • Arachidonic acid metabolism, conserved biosystem (from KEGG)
      Arachidonic acid metabolism, conserved biosystem
      Arachidonic acid metabolism
    • Ether lipid metabolism, organism-specific biosystem (from KEGG)
      Ether lipid metabolism, organism-specific biosystem
      Ether lipid metabolism
    • Ether lipid metabolism, conserved biosystem (from KEGG)
      Ether lipid metabolism, conserved biosystem
      Ether lipid metabolism
    • Fat digestion and absorption, organism-specific biosystem (from KEGG)
      Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fat digestion and absorption, conserved biosystem (from KEGG)
      Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
      Glycerophospholipid metabolism, organism-specific biosystem
      Glycerophospholipid metabolism
    • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
      Glycerophospholipid metabolism, conserved biosystem
      Glycerophospholipid metabolism
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Linoleic acid metabolism, organism-specific biosystem (from KEGG)
      Linoleic acid metabolism, organism-specific biosystem
      Linoleic acid metabolism
    • Linoleic acid metabolism, conserved biosystem (from KEGG)
      Linoleic acid metabolism, conserved biosystem
      Linoleic acid metabolism
    • Long-term depression, organism-specific biosystem (from KEGG)
      Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term depression, conserved biosystem (from KEGG)
      Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • alpha-Linolenic acid metabolism, organism-specific biosystem (from KEGG)
      alpha-Linolenic acid metabolism, organism-specific biosystem
      alpha-Linolenic acid metabolism
    • alpha-Linolenic acid metabolism, conserved biosystem (from KEGG)
      alpha-Linolenic acid metabolism, conserved biosystem
      alpha-Linolenic acid metabolism
    • phospholipases, organism-specific biosystem (from BIOCYC)
      phospholipases, organism-specific biosystem
      phospholipases

    Clone Names

    • MGC119918, MGC119919, MGC133367

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    arachidonic acid metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    axon guidance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    lysophospholipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		  
    phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of arachidonic acid secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of cellular protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of prostaglandin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    group 10 secretory phospholipase A2
    Names
    group 10 secretory phospholipase A2
    sPLA2-X
    GX sPLA2
    group X secretory phospholipase A2
    phosphatidylcholine 2-acylhydrolase 10
    NP_003552.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003561.1 → NP_003552.1  group 10 secretory phospholipase A2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      U95301
      Consensus CDS
      CCDS10555.1
      UniProtKB/Swiss-Prot
      O15496
      Related
      ENSP00000393847, OTTHUMP00000045725, ENST00000438167, OTTHUMT00000109393
      Conserved Domains (1) summary
      cd00125
      Location:43 – 157
      Blast Score: 372
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      14766405..14788526, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      14685697..14707807, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009167.9 (27162..49283) None
    genomic CH471112.2 EAW85104.1
    mRNA BC069539.1 AAH69539.1
    mRNA BC106731.1 AAI06732.1
    mRNA BC106732.1 AAI06733.1
    mRNA BC111804.1 AAI11805.1
    mRNA CR456885.1 CAG33166.1
    mRNA U95301.1 AAB64410.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    O15496.3 GenPept UniProtKB/Swiss-Prot:O15496
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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