TSSK6 testis-specific serine kinase 6 [Homo sapiens] - Gene

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Summary

Official Symbol: TSSK6provided by HGNC
Official Full Name: testis-specific serine kinase 6provided by HGNC
Primary source: HGNC:30410
Locus tag: FKSG82
See related: HPRD:15441; MIM:610712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT72; SSTK; TSSK4; FKSG82; FLJ24002
Summary: This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]

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Genomic context

Location :: 19p13.11

Sequence :: Chromosome: 19; NC_000019.9 (19625028..19626469, complement)

See TSSK6 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings, for the first time, suggested an association of c.822+126T>G/C in TSSK6 with spermatogenic impairment in humans in which allele T may be a risk factor for male infertility, while alleles C and G may decrease susceptibility to male infertility
Title: c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population.
Observational study of gene-disease association. (HuGE Navigator)
Title: c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population.
results demonstrate that SSTK is required for proper postmeiotic chromatin remodeling and male fertility
Title: Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9BXA6	P08238	HSP90AB1	HPRD	PubMed
Q9BXA6	Heat shock 70 KD protein 1A	HSPA1A	HPRD	PubMed
Q9BXA6	P11142	HSPA8	HPRD	PubMed
BioGRID:123835	BioGRID:109268	H2AFX	BioGRID	PubMed	Biochemical Activity
BioGRID:123835	BioGRID:170598	HIST1H1C	BioGRID	PubMed	Biochemical Activity
BioGRID:123835	BioGRID:113946	HIST1H3A	BioGRID	PubMed	Biochemical Activity
BioGRID:123835	BioGRID:113934	HIST2H2AC	BioGRID	PubMed	Biochemical Activity
BioGRID:123835	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123835	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123835	BioGRID:109544	HSPA8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123835	BioGRID:110325	MBP	BioGRID	PubMed	Biochemical Activity

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
sperm chromatin condensation	ISS Inferred from Sequence or Structural Similarity more info
spermatogenesis	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: testis-specific serine/threonine-protein kinase 6

Names: testis-specific serine/threonine-protein kinase 6; TSK-6; TSSK-6; cancer/testis antigen 72; testis-specific kinase 6; small serine/threonine kinase; serine/threonine protein kinase SSTK; serine/threonine-protein kinase SSTK

NP_114426.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032037.3 → NP_114426.1 testis-specific serine/threonine-protein kinase 6

Status: VALIDATED

Source sequence(s)

AA608857, AF348077

Consensus CDS

CCDS12403.1

UniProtKB/Swiss-Prot

Q9BXA6

Conserved Domains (2) summary

cd00180
Location:18 – 261
Blast Score: 501

PKc; Catalytic domain of Protein Kinases

smart00220
Location:12 – 261
Blast Score: 618

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

19625028..19626469, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

19187321..19188762, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011448.5 (76316..77757)	None
genomic	CH471106.1	EAW84824.1
		EAW84825.1
mRNA	AA608857.1	None
mRNA	AF329483.1	AAK48827.1
mRNA	AF348077.1	AAK29414.1
mRNA	AK058166.1	BAB71697.1
mRNA	AK172841.1	BAD18805.1
mRNA	AK313767.1	BAG36505.1
mRNA	BC014611.2	AAH14611.1
other-genetic	DQ891603.2	ABM82529.1
other-genetic	DQ894797.2	ABM85723.1