TSSK1B testis-specific serine kinase 1B [Homo sapiens] - Gene

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Summary

Official Symbol: TSSK1Bprovided by HGNC
Official Full Name: testis-specific serine kinase 1Bprovided by HGNC
Primary source: HGNC:14968
Locus tag: FKSG81
See related: Ensembl:ENSG00000212122; HPRD:11610; MIM:610709; Vega:OTTHUMG00000128835
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TSK1; TSSK1; FKSG81; SPOGA4; STK22D
Summary: TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

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Genomic context

Location :: 5q22.2

Sequence :: Chromosome: 5; NC_000005.9 (112768251..112770728, complement)

See TSSK1B in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_114417.1	NP_004603.1	TGFBR1	BIND	PubMed	T-beta-RI interacts with STK22D. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse STK22D.
NP_114417.1	NP_003233.3	TGFBR2	BIND	PubMed	T-beta-RII interacts with STK22D. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse STK22D.
Q9BXA7	O96017	CHEK2	HPRD	PubMed
Q9BXA7	P36897	TGFBR1	HPRD	PubMed
Q9BXA7	P37173	TGFBR2	HPRD	PubMed

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
spermatid development	ISS Inferred from Sequence or Structural Similarity more info
spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
acrosomal vesicle	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: testis-specific serine/threonine-protein kinase 1

Names: testis-specific serine/threonine-protein kinase 1; TSK-1; TSSK-1; testis-specific kinase 1; spermiogenesis associated 4; serine/threonine kinase FKSG81; testis-specific serine kinase 1; serine/threonine-protein kinase 22A; serine/threonine kinase 22D (spermiogenesis associated)

NP_114417.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032028.3 → NP_114417.1 testis-specific serine/threonine-protein kinase 1

Status: VALIDATED

Source sequence(s)

AK122904, BC022515, DB025324, DB527624

Consensus CDS

CCDS4112.1

UniProtKB/TrEMBL

A0ZT98

UniProtKB/Swiss-Prot

Q9BXA7

Related

ENSP00000375081, OTTHUMP00000159055, ENST00000390666, OTTHUMT00000250774

Conserved Domains (2) summary

cd00180
Location:18 – 269
Blast Score: 442

PKc; Catalytic domain of Protein Kinases

smart00220
Location:12 – 272
Blast Score: 615

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

112768251..112770728, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

107951168..107953645, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB284522.1	BAF41973.1
genomic	AC010431.7 (77435..79430)	None
genomic	CH471086.2	EAW48983.1
genomic	HC007364.1	CBH19487.1
genomic	HC044763.1	CBH30711.1
mRNA	AF348076.1	AAK29413.1
mRNA	AK122904.1	BAG53792.1
mRNA	AK313332.1	BAG36136.1
mRNA	AY028964.1	AAK27734.1
mRNA	BC022515.1	AAH22515.1
mRNA	DB025324.1	None
mRNA	DB527624.1	None
other-genetic	DQ893648.2	ABM84574.1
other-genetic	DQ895603.2	ABM86529.1