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    STK40 serine/threonine kinase 40 [ Homo sapiens ]

    Gene ID: 83931, updated on 11-May-2012
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    Summary

    Official Symbol
    STK40provided by HGNC
    Official Full Name
    serine/threonine kinase 40provided by HGNC
    Primary source
    HGNC:21373
    See related
    Ensembl:ENSG00000196182; HPRD:11359; MIM:609437; Vega:OTTHUMG00000008238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SHIK; SgK495; MGC4796; RP11-268J15.4
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    Genomic context

    Location :
    1p34.3
    Sequence :
    Chromosome: 1; NC_000001.10 (36805225..36851485, complement)
    See STK40 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene SH3 domain containing 21 Neighboring gene family with sequence similarity 176, member B Neighboring gene uncharacterized LOC100506594 Neighboring gene LSM10, U7 small nuclear RNA associated Neighboring gene organic solute carrier partner 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087.
    2. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
    4. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.
    5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. identification as a negative regulator of NF-kappaB- and p53-mediated gene transcription [SINK-homologous serine-threonine kinase]
      Title: Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8N2I9 Q7L5N1 COPS6    HPRD  PubMed  
    Q8N2I9 Q14181 POLA2    HPRD  PubMed  
    BioGRID:123816 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:123816 BioGRID:116915 NEDD4L    BioGRID  PubMed Reconstituted Complex 
    BioGRID:123816 BioGRID:117176 POLA2    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: LSM10

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    serine/threonine-protein kinase 40
    Names
    serine/threonine-protein kinase 40
    2310004N11Rik
    sugen kinase 495
    Ser/Thr-like kinase
    SINK-homologous serine/threonine-protein kinase
    NP_114406.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032017.1 → NP_114406.1  serine/threonine-protein kinase 40

      Status: PROVISIONAL

      Source sequence(s)
      AL834137
      Consensus CDS
      CCDS407.1
      UniProtKB/Swiss-Prot
      Q8N2I9
      Related
      ENSP00000362221, OTTHUMP00000009948, ENST00000373129, OTTHUMT00000022592
      Conserved Domains (2) summary
      smart00220
      Location:52 – 326
      Blast Score: 411
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:134 – 324
      Blast Score: 381
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      36805225..36851485, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      34921985..34968132, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC119675.2 (2000..19811) None
    genomic AL591845.27 CAH71862.1
      CAH71863.1
      CAH71864.1
    genomic CH471059.2 EAX07368.1
      EAX07369.1
      EAX07370.1
      EAX07371.1
      EAX07372.1
      EAX07373.1
    genomic CQ834750.1 CAH05590.1
    mRNA AK000808.1 None
    mRNA AK024504.1 BAB15794.1
    mRNA AK075029.1 BAC11361.1
    mRNA AK075048.1 BAC11371.1
    mRNA AK131560.1 BAD18694.1
    mRNA AL834137.1 CAD38852.1
    mRNA AY198395.1 AAP20040.1
    mRNA BC005169.2 AAH05169.3
    mRNA BC007835.2 AAH07835.2
    mRNA BC008344.1 AAH08344.1
    other-genetic AM392520.1 CAL37398.1
    other-genetic AM392535.1 CAL37413.1
    other-genetic AM392597.1 CAL37475.1
    other-genetic AM392770.1 CAL37648.1
    other-genetic AM392852.1 CAL37730.1
    other-genetic AM392953.1 CAL37831.1
    other-genetic AM392969.1 CAL37847.1
    other-genetic AM393274.1 CAL38152.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N2I9.2 GenPept UniProtKB/Swiss-Prot:Q8N2I9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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