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    KCTD10 potassium channel tetramerisation domain containing 10 [ Homo sapiens ]

    Gene ID: 83892, updated on 11-May-2012
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    Summary

    Official Symbol
    KCTD10provided by HGNC
    Official Full Name
    potassium channel tetramerisation domain containing 10provided by HGNC
    Primary source
    HGNC:23236
    Locus tag
    MSTP028
    See related
    Ensembl:ENSG00000110906; HPRD:13762; MIM:613421; Vega:OTTHUMG00000169253
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ULRO61; MSTP028; hBACURD3; FLJ41739
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    Genomic context

    Location :
    12q24.11
    Sequence :
    Chromosome: 12; NC_000012.11 (109886460..109915155, complement)
    See KCTD10 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene forkhead box N4 Neighboring gene myosin IH Neighboring gene ubiquitin protein ligase E3B Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblB type

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    2. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. For the SNPs KCTD10_i5642G-->C and MVK_S52NG-->A, homozygotes for the major alleles (G) had lower HDL-cholesterol concentrations than did carriers of the minor alleles (P = 0.005 and P = 0.019, respectively).
      Title: Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.
    4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.
    5. KCTD10 may be associated with DNA synthesis and cell proliferation
      Title: KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation.
    6. binding of SP1 to the proximal promoter region stimulated the promoter activity and endogenous KCTD10 expression, whereas binding of AP-2alpha to this region showed opposite effects.
      Title: Transcription factor specificity protein 1 (SP1) and activating protein 2alpha (AP-2alpha) regulate expression of human KCTD10 gene by binding to proximal region of promoter.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Common variants at 30 loci contribute to polygenic dyslipidemia.

    Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:123803 BioGRID:110433 ATXN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123803 BioGRID:198584 Cd2ap    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123803 BioGRID:129001 KCTD13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123803 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123803 BioGRID:114465 USP13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:123803 BioGRID:118895 USP25    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to ubiquitin-protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    BTB/POZ domain-containing protein KCTD10
    potassium channel tetramerization domain-containing protein 10
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031954.3 → NP_114160.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

      Status: PROVISIONAL

      Source sequence(s)
      AY205299
      Consensus CDS
      CCDS9128.1
      UniProtKB/Swiss-Prot
      Q9H3F6
      Related
      ENSP00000228495, OTTHUMP00000240540, ENST00000228495, OTTHUMT00000403099
      Conserved Domains (1) summary
      cl02518
      Location:34 – 124
      Blast Score: 232
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      109886460..109915155, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      106904465..106933134, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC007570.23 (128818..157513) None
    genomic CH471054.1 EAW97860.1
      EAW97861.1
      EAW97862.1
      EAW97863.1
      EAW97864.1
    mRNA AB209358.1 BAD92595.1
    mRNA AF113208.1 AAG39279.1
    mRNA AK027543.1 BAB55188.1
    mRNA AK056912.1 None
    mRNA AK092170.1 BAG52491.1
    mRNA AK123733.1 BAG53947.1
    mRNA AK222548.1 BAD96268.1
    mRNA AK309783.1 None
    mRNA AY205299.1 AAO47716.1
    mRNA AY597809.1 AAT09002.1
    mRNA BC040062.1 AAH40062.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H3F6.1 GenPept UniProtKB/Swiss-Prot:Q9H3F6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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