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NME5 NME/NM23 family member 5 [ Homo sapiens (human) ]

Gene ID: 8382, updated on 8-May-2016
Official Symbol
NME5provided by HGNC
Official Full Name
NME/NM23 family member 5provided by HGNC
Primary source
HGNC:HGNC:7853
See related
Ensembl:ENSG00000112981 HPRD:04655; MIM:603575; Vega:OTTHUMG00000129207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NM23H5; RSPH23; NM23-H5
Orthologs
Location:
5q31
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (138115172..138139443, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137450861..137475132, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 13 member B Neighboring gene uncharacterized LOC100130172 Neighboring gene Wnt family member 8A Neighboring gene bromodomain containing 8 Neighboring gene kinesin family member 20A Neighboring gene cell division cycle 23

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
epithelial cilium movement IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleoside diphosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
nucleoside metabolic process TAS
Traceable Author Statement
more info
PubMed 
spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
ventricular system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
intracellular IBA
Inferred from Biological aspect of Ancestor
more info
 
sperm flagellum IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nucleoside diphosphate kinase homolog 5
Names
IPIA-beta
NDK-H 5
NDP kinase homolog 5
inhibitor of p53-induced apoptosis-beta
non-metastatic cells 5 protein expressed in
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
radial spoke 23 homolog
testis-specific nm23 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003551.2NP_003542.1  nucleoside diphosphate kinase homolog 5

    See identical proteins and their annotated locations for NP_003542.1

    Status: VALIDATED

    Source sequence(s)
    AF067724, BC026182, BM979998, BX490554
    Consensus CDS
    CCDS4197.1
    UniProtKB/Swiss-Prot
    P56597
    UniProtKB/TrEMBL
    A0A0S2Z4L9
    Related
    ENSP00000265191, OTTHUMP00000159495, ENST00000265191, OTTHUMT00000251286
    Conserved Domains (3) summary
    smart00562
    Location:13148
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04418
    Location:13144
    NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
    pfam05186
    Location:156197
    Dpy-30; Dpy-30 motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    138115172..138139443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714716.2XP_006714779.1  

    Conserved Domains (2) summary
    smart00562
    Location:13146
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04418
    Location:13144
    NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
  2. XM_011543663.1XP_011541965.1  

    Conserved Domains (2) summary
    pfam05186
    Location:119150
    Dpy-30; Dpy-30 motif
    cl00335
    Location:6107
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
  3. XM_011543662.1XP_011541964.1  

    Conserved Domains (3) summary
    smart00562
    Location:13148
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04418
    Location:13144
    NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
    pfam05186
    Location:156187
    Dpy-30; Dpy-30 motif
  4. XM_005272099.1XP_005272156.1  

    Conserved Domains (2) summary
    smart00562
    Location:13148
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04418
    Location:13144
    NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    136883576..136907841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)