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KCNK16 potassium two pore domain channel subfamily K member 16 [ Homo sapiens (human) ]

Gene ID: 83795, updated on 13-Aug-2016
Official Symbol
KCNK16provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 16provided by HGNC
Primary source
HGNC:HGNC:14464
See related
Ensembl:ENSG00000095981 HPRD:09565; MIM:607369; Vega:OTTHUMG00000014645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TALK1; TALK-1; K2p16.1
Summary
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Orthologs
Location:
6p21.2-p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (39314566..39322992, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (39282474..39290330, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 5 Neighboring gene uncharacterized LOC105375047 Neighboring gene potassium two pore domain channel subfamily K member 17 Neighboring gene uncharacterized LOC107986594 Neighboring gene ankyrin repeat domain 39 pseudogene Neighboring gene kinesin family member 6 Neighboring gene E2F transcription factor 4 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
NHGRI GWA Catalog
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
    Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • TWIK-related alkaline pH activated K+ channel (TALK), organism-specific biosystem (from REACTOME)
    TWIK-related alkaline pH activated K+ channel (TALK), organism-specific biosystemTWIK related alkaline pH activated K+ channels are activated by increase in the extracellular pH. TALK1 and TALK 2 are members of the TALK subfamily and are both are activated by rise in extracellul...
  • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
    Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC133123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel activity TAS
Traceable Author Statement
more info
 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
potassium channel subfamily K member 16
Names
2P domain potassium channel Talk-1
TWIK-related alkaline pH-activated K(+) channel 1
pancreatic potassium channel Talk-1
potassium channel, subfamily K, member 16
potassium channel, two pore domain subfamily K, member 16

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135105.1NP_001128577.1  potassium channel subfamily K member 16 isoform 1

    See identical proteins and their annotated locations for NP_001128577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as TALK-1c) encodes the longest isoform (1).
    Source sequence(s)
    BC111860, BP387644, CA843225
    Consensus CDS
    CCDS47421.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000391498, OTTHUMP00000223326, ENST00000425054, OTTHUMT00000372088
    Conserved Domains (1) summary
    pfam07885
    Location:86144
    Ion_trans_2; Ion channel
  2. NM_001135106.1NP_001128578.1  potassium channel subfamily K member 16 isoform 3

    See identical proteins and their annotated locations for NP_001128578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as TALK-1b) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF358909, BC111860, CA843225, EU978943
    Consensus CDS
    CCDS47422.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000415375, OTTHUMP00000223325, ENST00000437525, OTTHUMT00000372087
    Conserved Domains (1) summary
    pfam07885
    Location:86144
    Ion_trans_2; Ion channel
  3. NM_001135107.1NP_001128579.1  potassium channel subfamily K member 16 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as TALK-1d) uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (4) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC111860, BP387644, CA843225
    Consensus CDS
    CCDS47420.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000362324, OTTHUMP00000223327, ENST00000373227, OTTHUMT00000372089
    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel
  4. NM_032115.3NP_115491.1  potassium channel subfamily K member 16 isoform 2

    See identical proteins and their annotated locations for NP_115491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as TALK-1a) contains an additional coding exon and uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF358909, BC111860, BP387644, CA843225
    Consensus CDS
    CCDS4843.1
    UniProtKB/Swiss-Prot
    Q96T55
    Related
    ENSP00000362326, OTTHUMP00000016345, ENST00000373229, OTTHUMT00000040452
    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

    Range
    39314566..39322992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011346.1XP_016866835.1  

    Conserved Domains (1) summary
    pfam07885
    Location:92148
    Ion_trans_2; Ion channel
  2. XM_011514935.2XP_011513237.1  

    UniProtKB/TrEMBL
    D6RC57
    Related
    ENSP00000423842, OTTHUMP00000223328, ENST00000507712, OTTHUMT00000372090
    Conserved Domains (1) summary
    pfam07885
    Location:2179
    Ion_trans_2; Ion channel

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    39285120..39292976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)