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GRWD1 glutamate-rich WD repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 83743, updated on 8-May-2016
Official Symbol
GRWD1provided by HGNC
Official Full Name
glutamate-rich WD repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:21270
See related
Ensembl:ENSG00000105447 HPRD:11013; MIM:610597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDW4; GRWD; RRB1; WDR28
Summary
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Orthologs
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (48445773..48453907)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48949030..48957164)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene synaptogyrin 4 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 1 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2D Neighboring gene potassium voltage-gated channel subfamily J member 14 Neighboring gene uncharacterized LOC105372430 Neighboring gene cytohesin 2

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: KCNJ14

Homology

Clone Names

  • KIAA1942

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
glutamate-rich WD repeat-containing protein 1
Names
CUL4- and DDB1-associated WDR protein 4
WD repeat domain 28
glutamate rich WD repeat protein GRWD
regulator of ribosome biogenesis 1 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046925.1 RefSeqGene

    Range
    5001..13135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_031485.3NP_113673.3  glutamate-rich WD repeat-containing protein 1

    See identical proteins and their annotated locations for NP_113673.3

    Status: REVIEWED

    Source sequence(s)
    BC002440, DA200417, DA714522
    Consensus CDS
    CCDS12720.1
    UniProtKB/Swiss-Prot
    Q9BQ67
    UniProtKB/TrEMBL
    A0MNN5
    Related
    ENSP00000253237, OTTHUMP00000271411, ENST00000253237, OTTHUMT00000466122
    Conserved Domains (3) summary
    COG2319
    Location:197383
    WD40; WD40 repeat [General function prediction only]
    pfam12265
    Location:43113
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl02567
    Location:204384
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    48445773..48453907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    48950885..48958983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)