RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001225.3 → NP_001216.1 caspase-4 isoform alpha precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (alpha) encodes the longest isoform (alpha).
- Source sequence(s)
-
AI128358, CN261701, Z48810
- Consensus CDS
-
CCDS8327.1
- UniProtKB/TrEMBL
-
A2NHL8
- UniProtKB/Swiss-Prot
-
P49662
- Related
- ENSP00000388566, OTTHUMP00000231863, ENST00000444739, OTTHUMT00000387751
- Conserved Domains (2) summary
-
- cd00032
Location:125 – 374
Blast Score: 659
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
- cd08325
Location:5 – 81
Blast Score: 204
- CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
-
NM_033306.2 → NP_150649.1 caspase-4 isoform gamma precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (gamma) includes an alternate exon in the 5' UTR and 5' coding region and uses a downstream in-frame start codon, compared to variant alpha. It encodes isoform gamma, which is shorter than isoform alpha.
- Source sequence(s)
-
AI128358, U28978
- Consensus CDS
-
CCDS41704.1
- UniProtKB/TrEMBL
-
A2NHM0
- Related
- ENSP00000376857, OTTHUMP00000231864, ENST00000393150, OTTHUMT00000387752
- Conserved Domains (2) summary
-
- cd00032
Location:69 – 318
Blast Score: 656
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
- cl14633
Location:1 – 25
Blast Score: 89
- DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains
RefSeqs of Annotated Genomes: Build 37.3
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000011.9 Reference GRCh37.p5 Primary Assembly
- Range
- 104813594..104839325, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000143.1 Alternate HuRef
- Range
- 100744534..100770269, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Suppressed Reference Sequence(s)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_033307.2: Suppressed sequence
- Description
- NM_033307.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.