HIST1H4G histone cluster 1, H4g [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: HIST1H4Gprovided by HGNC
Official Full Name: histone cluster 1, H4gprovided by HGNC
Primary source: HGNC:4792
See related: Ensembl:ENSG00000124578; HPRD:11806; MIM:602832; Vega:OTTHUMG00000014444
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H4/l; H4FL
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 6p22.1

Sequence :: Chromosome: 6; NC_000006.11 (26246839..26247205, complement)

See HIST1H4G in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:113965	BioGRID:1205541	tat		BioGRID	PubMed	Protein-peptide

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromosome	IEA Inferred from Electronic Annotation more info
nucleosome	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: histone H4-like protein type G

Names: histone H4-like protein type G; histone 1, H4g; H4 histone family, member L

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003547.2 → NP_003538.1 histone H4-like protein type G

Status: REVIEWED

Source sequence(s)

Z80788

Consensus CDS

CCDS4599.1

UniProtKB/Swiss-Prot

Q99525

Related

ENSP00000244537, OTTHUMP00000016158, ENST00000244537, OTTHUMT00000040107

Conserved Domains (1) summary

cd00076
Location:19 – 98
Blast Score: 232

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

26246839..26247205, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

26189844..26190210, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL031777.5	CAB39187.1
genomic	AY128660.1	AAN01445.1
genomic	CH471087.1	EAW55550.1
genomic	Z80788.1	CAB02550.1
mRNA	BC126276.1	AAI26277.1
mRNA	BC126278.1	AAI26279.1
other-genetic	HQ258035.1	ADR82789.1