TLN2 talin 2 [Homo sapiens] - Gene

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Summary

Official Symbol: TLN2provided by HGNC
Official Full Name: talin 2provided by HGNC
Primary source: HGNC:15447
See related: Ensembl:ENSG00000171914; HPRD:09555; MIM:607349; Vega:OTTHUMG00000133679
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ILWEQ; KIAA0320; DKFZp451B1011; DKFZp686I0976; DKFZp686K0979
Summary: This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 15q15-q21

Sequence :: Chromosome: 15; NC_000015.9 (62939510..63136830)

See TLN2 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that SCGB3A1 was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 were up-regulated in invasive compared with DCIS.
Title: Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas.
This review discusses the general function of talin 1 and talin 2, as well as vinculin/metavinulin, with emphasis on what is understood about their role in the cardiac myocyte and in whole heart.
Title: Vinculin and talin: focus on the myocardium.
Structural diversity in integrin/talin interactions.
Title: Structural diversity in integrin/talin interactions.
the differential concentration of CSF and serum-talin 2 in the drug-refractory postencephalitic epilepsy group is an intractability-related phenomenon that might be involved in the development of RPEE
Title: Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Data show that TLN2n presents only in the CSF of temporal lobe epilepsy patients.
Title: Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy.
Talin2 may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle.
Title: Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle.
we show that the predominant brain splice variant of PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short carboxy-terminal peptide, to the FERM domain of talin, and is strongly activated by this interaction
Title: Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.
The F-actin binding capacity of Talin 2 is regulated by intrasteric occlusion of primary actin-binding determinants within the talin I/LWEQ module.
Title: Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9Y4G6	O60331	PIP5K1C	HPRD	PubMed
BioGRID:123717	BioGRID:216476	Cep350	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123717	BioGRID:116969	PIP5K1C	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:123717	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
actin binding	NAS Non-traceable Author Statement more info	PubMed
insulin receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
structural molecule activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	NAS Non-traceable Author Statement more info	PubMed
cell-cell junction assembly	TAS Traceable Author Statement more info	PubMed
cytoskeletal anchoring at plasma membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
actin cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
cell-cell junction	IC Inferred by Curator more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
focal adhesion	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
ruffle	IEA Inferred from Electronic Annotation more info
synapse	NAS Non-traceable Author Statement more info	PubMed

General protein information

Preferred Names: talin-2

Names: talin-2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015059.2 → NP_055874.2 talin-2

Status: REVIEWED

Source sequence(s)

AC068233, AC100839, AC103740, AF402000

Consensus CDS

CCDS32261.1

UniProtKB/Swiss-Prot

Q9Y4G6

Related

ENSP00000303476, ENST00000306829

Conserved Domains (8) summary

smart00307
Location:2337 – 2532
Blast Score: 420

ILWEQ; I/LWEQ domain

pfam09141
Location:494 – 655
Blast Score: 581

Talin_middle; Talin, middle domain

cd00836
Location:310 – 403
Blast Score: 197

FERM_C; FERM_C domain

smart00295
Location:90 – 316
Blast Score: 491

B41; Band 4.1 homologues

pfam00373
Location:209 – 316
Blast Score: 302

FERM_M; FERM central domain

pfam01608
Location:2342 – 2473
Blast Score: 431

I_LWEQ; I/LWEQ domain

pfam08913
Location:1850 – 1974
Blast Score: 547

VBS; Vinculin Binding Site

pfam09379
Location:92 – 201
Blast Score: 177

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

62939510..63136830

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

39762354..39959569

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB304389.1	None
genomic	AB304390.1	None
genomic	AB304391.1	None
genomic	AB304392.1	None
genomic	AB304393.1	None
genomic	AB304394.1	None
genomic	AB304395.1	None
genomic	AC068233.12 (8883..132709)	None
genomic	AC100839.2	None
genomic	AC103740.2	None
genomic	AL122065.1	None
genomic	CH471082.1	EAW77615.1
		EAW77616.1
		EAW77617.1
mRNA	AB002318.2	BAA20778.2
mRNA	AB621808.1	BAK64144.1
mRNA	AF007154.1	None
mRNA	AF070527.1	None
mRNA	AF085910.1	None
mRNA	AF402000.1	AAM73764.1
mRNA	AK294570.1	BAG57764.1
mRNA	BX647654.1	None
mRNA	BX648144.1	None
mRNA	BX648146.1	None