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Cdkn1b cyclin-dependent kinase inhibitor 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 83571, updated on 29-May-2016
Official Symbol
Cdkn1bprovided by RGD
Official Full Name
cyclin-dependent kinase inhibitor 1Bprovided by RGD
Primary source
RGD:69062
See related
Ensembl:ENSRNOG00000007249
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
p27; Kip1; CDKN4; Cdki1b; P27KIP1
Summary
inhibits the activity of cyclin-CDK complexes and plays a role in cell cycle control [RGD, Feb 2006]
Orthologs
Location:
4q43
Exon count:
3
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168689046..168694159)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (232962218..232967323)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein-like 2 Neighboring gene G protein-coupled receptor 19 Neighboring gene proteasome maturation protein pseudogene Neighboring gene apolipoprotein L domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activator activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
autophagic cell death IEA
Inferred from Electronic Annotation
more info
 
autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
cellular response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
inner ear development ISO
Inferred from Sequence Orthology
more info
 
mitotic cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular component movement IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular component movement ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Cul4A-RING E3 ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cyclin-dependent kinase inhibitor 1B
Names
Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
cyclin-dependent kinase inhibitor p27
cyclin-dependent kinase inhibitor p27/Kip1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031762.3NP_113950.2  cyclin-dependent kinase inhibitor 1B

    See identical proteins and their annotated locations for NP_113950.2

    Status: PROVISIONAL

    Source sequence(s)
    AY623040
    UniProtKB/TrEMBL
    O08769
    Related
    ENSRNOP00000050173, ENSRNOT00000049848
    Conserved Domains (1) summary
    pfam02234
    Location:3080
    CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    168689046..168694159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237539.2XP_006237601.1  

    See identical proteins and their annotated locations for XP_006237601.1

    UniProtKB/TrEMBL
    O08769
    Conserved Domains (1) summary
    pfam02234
    Location:3080
    CDI; Cyclin-dependent kinase inhibitor

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    156357827..156362628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)