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Aifm1 apoptosis inducing factor, mitochondria associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83533, updated on 26-May-2016
Official Symbol
Aifm1provided by RGD
Official Full Name
apoptosis inducing factor, mitochondria associated 1provided by RGD
Primary source
RGD:620817
See related
Ensembl:ENSRNOG00000006067
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Aif; Pdcd8
Summary
may facilitate apoptotic chromatin condensation and DNA degradation [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Orthologs
Location:
Xq35
Exon count:
16
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135304063..135343062, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (135375533..135414532, complement)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene UTP14A small subunit processome component Neighboring gene BCL6 co-repressor-like 1 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene zinc finger protein 280C

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation by HSP70, organism-specific biosystem
    Apoptosis Modulation by HSP70
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
FAD binding IEA
Inferred from Electronic Annotation
more info
 
FAD binding ISO
Inferred from Sequence Orthology
more info
 
NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 
NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to aldosterone IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to oxygen-glucose deprivation IEP
Inferred from Expression Pattern
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial respiratory chain complex I assembly IEA
Inferred from Electronic Annotation
more info
 
mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
 
neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
response to L-glutamate IEP
Inferred from Expression Pattern
more info
PubMed 
response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
NOT response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
apoptosis-inducing factor 1, mitochondrial
Names
apoptosis-inducing factor, mitochondrion-associated 1
programmed cell death 8 (apoptosis-inducing factor)
programmed cell death protein 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031356.1NP_112646.1  apoptosis-inducing factor 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_112646.1

    Status: PROVISIONAL

    Source sequence(s)
    AB041723
    UniProtKB/Swiss-Prot
    Q9JM53
    Related
    ENSRNOP00000008503, ENSRNOT00000008503
    Conserved Domains (4) summary
    pfam00070
    Location:301385
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:149443
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:464594
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
    pfam14962
    Location:51114
    AIF-MLS; Mitochondria Localisation Sequence

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    135304063..135343062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    126598666..126637656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)