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Cdh2 cadherin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83501, updated on 26-May-2016
Official Symbol
Cdh2provided by RGD
Official Full Name
cadherin 2provided by RGD
Primary source
RGD:69280
See related
Ensembl:ENSRNOG00000015602
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
N-cadherin
Summary
cell-cell adhesion molecule; may play a role in smooth muscle cell migration and adhesion in response to injury [RGD, Feb 2006]
Orthologs
Location:
18p13
Exon count:
17
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (8146971..8366037, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (7997533..8218018, complement)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene similar to prohibitin Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene uncharacterized LOC102552679 Neighboring gene similar to ubiquitin-conjugating enzyme E2 variant 1 Neighboring gene similar to 60S ribosomal protein L6 (Neoplasm-related protein C140)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
alpha-catenin binding IEA
Inferred from Electronic Annotation
more info
 
alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
gamma-catenin binding IEA
Inferred from Electronic Annotation
more info
 
gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
brain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
brain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
cell-cell adhesion mediated by cadherin ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
neuroepithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
neuroepithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
neuroligin clustering involved in postsynaptic membrane assembly IEA
Inferred from Electronic Annotation
more info
 
neuroligin clustering involved in postsynaptic membrane assembly ISO
Inferred from Sequence Orthology
more info
 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
neuronal stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic vesicle clustering ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization IPI
Inferred from Physical Interaction
more info
PubMed 
radial glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
radial glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of oligodendrocyte progenitor proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of oligodendrocyte progenitor proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of postsynaptic density protein 95 clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic density protein 95 clustering ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
single organismal cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
telencephalon development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
catenin complex IEA
Inferred from Electronic Annotation
more info
 
catenin complex ISO
Inferred from Sequence Orthology
more info
 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
fascia adherens IDA
Inferred from Direct Assay
more info
PubMed 
fascia adherens IEA
Inferred from Electronic Annotation
more info
 
fascia adherens ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
intercalated disc ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cadherin-2
Names
cadherin 2 type 1 N-cadherin (neuronal)
cadherin 2, type 1, N-cadherin (neuronal)
neural cadherin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031333.1NP_112623.1  cadherin-2 precursor

    See identical proteins and their annotated locations for NP_112623.1

    Status: PROVISIONAL

    Source sequence(s)
    AB017695
    UniProtKB/Swiss-Prot
    Q9Z1Y3
    Related
    ENSRNOP00000021170, ENSRNOT00000021170
    Conserved Domains (4) summary
    cd11304
    Location:273378
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:749904
    Cadherin_C; Cadherin cytoplasmic region
    pfam08758
    Location:31121
    Cadherin_pro; Cadherin prodomain like
    cl15786
    Location:163263
    CA_like; Cadherin repeat-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    8146971..8366037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254441.1XP_006254503.1  

    See identical proteins and their annotated locations for XP_006254503.1

    UniProtKB/TrEMBL
    G3V803
    Conserved Domains (4) summary
    cd11304
    Location:273378
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:749904
    Cadherin_C; Cadherin cytoplasmic region
    pfam08758
    Location:31121
    Cadherin_pro; Cadherin prodomain like
    cl15786
    Location:163263
    CA_like; Cadherin repeat-like domain

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    7938006..8155134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)