Display Settings:

Format

Send to:

Choose Destination

ARHGAP24 Rho GTPase activating protein 24 [ Homo sapiens (human) ]

Gene ID: 83478, updated on 26-Aug-2014
Official Symbol
ARHGAP24provided by HGNC
Official Full Name
Rho GTPase activating protein 24provided by HGNC
Primary source
HGNC:25361
See related
Ensembl:ENSG00000138639; HPRD:09804; MIM:610586; Vega:OTTHUMG00000130427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP
Summary
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
See ARHGAP24 in Epigenomics, MapViewer
Location:
4q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (85147742..86002670)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (86068860..86923823)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene WD repeat and FYVE domain containing 3 Neighboring gene WDFY3 antisense RNA 2 Neighboring gene quinone oxidoreductase-like protein 2 pseudogene Neighboring gene uncharacterized LOC101929015 Neighboring gene microRNA 4451 Neighboring gene uncharacterized LOC101929064 Neighboring gene mitogen-activated protein kinase 10 Neighboring gene microRNA 4452

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of PR interval.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
NHGRI GWA Catalog
Several common variants modulate heart rate, PR interval and QRS duration.
NHGRI GWA Catalog
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ33877, DKFZp564B1162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rac GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of Rac GTPase activity IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
wound healing, spreading of epidermal cells IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho GTPase-activating protein 24
Names
rho GTPase-activating protein 24
rhoGAP of 73 kDa
sarcoma antigen NY-SAR-88
filamin-A-associated RhoGAP
rho-type GTPase-activating protein 24
RAC1- and CDC42-specific GTPase-activating protein of 72 kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025616.2NP_001020787.2  rho GTPase-activating protein 24 isoform 1

    See proteins identical to NP_001020787.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC104059, AK091196, BC098580, DA815489, DB109452
    Consensus CDS
    CCDS34025.1
    UniProtKB/Swiss-Prot
    Q8N264
    Related
    ENSP00000378611, OTTHUMP00000160982, ENST00000395184, OTTHUMT00000252815
    Conserved Domains (3) summary
    cd04390
    Location:131329
    Blast Score: 1024
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13379
    Location:18131
    Blast Score: 702
    PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain
    cl19113
    Location:661724
    Blast Score: 85
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. NM_001042669.1NP_001036134.1  rho GTPase-activating protein 24 isoform 3

    See proteins identical to NP_001036134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC104059, BC098580, DA546029
    Consensus CDS
    CCDS43246.1
    UniProtKB/Swiss-Prot
    Q8N264
    Conserved Domains (3) summary
    cd04390
    Location:36234
    Blast Score: 1023
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl17171
    Location:136
    Blast Score: 223
    PH-like; Pleckstrin homology-like domain
    cl19113
    Location:566629
    Blast Score: 84
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. NM_001287805.1NP_001274734.1  rho GTPase-activating protein 24 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC104059, AK307423
    Conserved Domains (3) summary
    cd04390
    Location:46244
    Blast Score: 1023
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl17171
    Location:346
    Blast Score: 263
    PH-like; Pleckstrin homology-like domain
    cl19113
    Location:576639
    Blast Score: 85
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. NM_031305.2NP_112595.2  rho GTPase-activating protein 24 isoform 2

    See proteins identical to NP_112595.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC098870, AC104059, BC098580
    Consensus CDS
    CCDS3611.1
    UniProtKB/Swiss-Prot
    Q8N264
    Related
    ENSP00000264343, OTTHUMP00000160983, ENST00000264343, OTTHUMT00000252816
    Conserved Domains (2) summary
    cd04390
    Location:38236
    Blast Score: 1022
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl19113
    Location:568631
    Blast Score: 85
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    85147742..86002670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263263.2XP_005263320.1  

    See proteins identical to XP_005263320.1

    UniProtKB/Swiss-Prot
    Q8N264
    Conserved Domains (3) summary
    cd04390
    Location:131329
    Blast Score: 1024
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13379
    Location:18131
    Blast Score: 702
    PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain
    cl19113
    Location:661724
    Blast Score: 85
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    82138172..82667459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    86373874..86900523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)