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HIST1H2BI histone cluster 1, H2bi [ Homo sapiens (human) ]

Gene ID: 8346, updated on 11-Sep-2014
Official Symbol
HIST1H2BIprovided by HGNC
Official Full Name
histone cluster 1, H2biprovided by HGNC
Primary source
HGNC:HGNC:4756
See related
Ensembl:ENSG00000278588; HPRD:11903; MIM:602807; Vega:OTTHUMG00000014448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2B/k; H2BFK
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
See HIST1H2BI in Epigenomics, MapViewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (26272976..26273412)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26273204..26273640)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene histone cluster 1, H3g Neighboring gene histone cluster 1, H2a, pseudogene 4 Neighboring gene histone cluster 1, H4h Neighboring gene transfer RNA-iMet (CAT) 1-3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
histone H2B type 1-C/E/F/G/I
Names
histone H2B type 1-C/E/F/G/I
histone H2B.k
histone 1, H2bi
histone H2B.1 A
H2B histone family, member K

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003525.2NP_003516.1  histone H2B type 1-C/E/F/G/I

    See proteins identical to NP_003516.1

    Status: REVIEWED

    Source sequence(s)
    Z80782
    Consensus CDS
    CCDS4603.1
    UniProtKB/TrEMBL
    B2R4S9
    UniProtKB/Swiss-Prot
    P62807
    Related
    ENSP00000366962, OTTHUMP00000016162, ENST00000377733, OTTHUMT00000040111
    Conserved Domains (1) summary
    smart00427
    Location:28124
    Blast Score: 411
    H2B; Histone H2B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    26272976..26273412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    26216211..26216647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    26275364..26275800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)