INO80B INO80 complex subunit B [Homo sapiens] - Gene

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Summary

Official Symbol: INO80Bprovided by HGNC
Official Full Name: INO80 complex subunit Bprovided by HGNC
Primary source: HGNC:13324
See related: Ensembl:ENSG00000115274; HPRD:17110; Vega:OTTHUMG00000129959
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IES2; hIes2; PAPA-1; ZNHIT4; HMGA1L4; HMGIYL4; PAP-1BP
Summary: This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011]

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Genomic context

Location :: 2p13.1

Sequence :: Chromosome: 2; NC_000002.11 (74682150..74685087)

See INO80B in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9C086	P60033	CD81	HPRD	PubMed
Q9C086	Q96RL1	UIMC1	HPRD	PubMed
BioGRID:123646	BioGRID:106601	ACTL6A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:122993	ACTR5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:125062	ACTR8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:107413	CD81	BioGRID	PubMed	Two-hybrid
BioGRID:123646	BioGRID:120076	INO80	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:123646	INO80B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:125928	INO80C	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:120238	INO80D	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:129701	INO80E	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:115710	MCRS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:110864	NFRKB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:114166	RUVBL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:116067	RUVBL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:118931	TFPT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123646	BioGRID:113360	YY1	BioGRID	PubMed	Affinity Capture-MS; Co-localization

Function	Evidence Code	Pubs
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
DNA recombination	IEA Inferred from Electronic Annotation more info
DNA repair	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Ino80 complex	IDA Inferred from Direct Assay more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: INO80 complex subunit B

Names: INO80 complex subunit B; IES2 homolog; PAP-1 binding protein; zinc finger, HIT type 4; PAP-1-associated protein 1; high mobility group AT-hook 1-like 4; zinc finger HIT domain-containing protein 4; PAP (Pim-1 associated protein) associated protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031288.3 → NP_112578.2 INO80 complex subunit B

Status: REVIEWED

Source sequence(s)

AI978697, BC064425, DB451812

Consensus CDS

CCDS1942.2

UniProtKB/Swiss-Prot

Q9C086

Related

ENSP00000233331, OTTHUMP00000160419, ENST00000233331, OTTHUMT00000252223

Conserved Domains (2) summary

pfam04438
Location:319 – 336
Blast Score: 83

zf-HIT; HIT zinc finger

pfam04795
Location:234 – 293
Blast Score: 109

PAPA-1; PAPA-1-like conserved region

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

74682150..74685087

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

74418445..74421382

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005041.2 (77355..80180)	None
genomic	CH471053.2	EAW99668.1
mRNA	AB054538.1	BAB21111.1
mRNA	AI978697.1	None
mRNA	AK295889.1	BAG58684.1
mRNA	AK295901.1	BAG58693.1
mRNA	BC039617.1	None
mRNA	BC050666.2	AAH50666.2
mRNA	BC064425.1	AAH64425.2
mRNA	CN260703.1	None
mRNA	DB451812.1	None