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    FZD8 frizzled family receptor 8 [ Homo sapiens ]

    Gene ID: 8325, updated on 8-Jan-2012

    Summary

    Official Symbol
    FZD8provided by HGNC
    Official Full Name
    frizzled family receptor 8provided by HGNC
    Primary source
    HGNC:4046
    See related
    Ensembl:ENSG00000177283; HPRD:05852; MIM:606146; Vega:OTTHUMG00000017956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FZ-8; hFZ8
    Summary
    This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    10p11.21
    Sequence :
    Chromosome: 10; NC_000010.10 (35927177..35930362, complement)
    See FZD8 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene cyclin Y Neighboring gene microRNA 4683 Neighboring gene gap junction protein, delta 4, 40.1kDa Neighboring gene ribosomal protein L7 pseudogene 37 Neighboring gene nicotinamide phosphoribosyltransferase-like

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_114072.1 NP_002949.1 RYK    BIND  PubMed Frizzled-8 interacts with Ryk. This interaction was modeled on a demonstrated interaction between Frizzled-8 and Ryk from unspecified species. 
    NP_114072.1 NP_005421.1 WNT1    BIND  PubMed Frizzled-8 interacts with Wnt-1. This interaction was modeled on a demonstrated interaction between Frizzled-8 and Wnt-1 from unspecified species. 
    Q9H461 Q9HD26 GOPC    HPRD  PubMed  
    Q9H461 O75197 LRP5    HPRD  PubMed  
    Q9H461 O75581 LRP6    HPRD  PubMed  
    Q9H461 P34925 RYK    HPRD  PubMed  
    Q9H461 P04628 WNT1    HPRD  PubMed  
    BioGRID:113921 BioGRID:110220 LRP5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113921 BioGRID:110219 LRP6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113921 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113921 BioGRID:113308 WNT1    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling network, organism-specific biosystem (from Pathway Interaction Database)
      Wnt signaling network, organism-specific biosystem
      Wnt signaling network
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Wnt-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-activated receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell differentiation in thymus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    canonical Wnt receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    embryo development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    vasculature development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral to membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    frizzled-8
    Names
    frizzled-8
    frizzled homolog 8
    frizzled 8, seven transmembrane spanning receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029968.1 RefSeqGene

      Range
      5001..8186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_031866.2NP_114072.1  frizzled-8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121749
      Consensus CDS
      CCDS7192.1
      UniProtKB/Swiss-Prot
      Q9H461
      Related
      ENSP00000363826, OTTHUMP00000019454, ENST00000374694, OTTHUMT00000047575
      Conserved Domains (2) summary
      cd07461
      Location:35155
      Blast Score: 706
      CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor.
      pfam01534
      Location:267623
      Blast Score: 1305
      Frizzled; Frizzled/Smoothened family membrane region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      35927177..35930362, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      35646354..35649248, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL121749.14 CAC10185.1
    genomic CH471072.2 EAW85909.1
    mRNA AB043703.1 BAB41064.1
    mRNA AF086500.1 None
    other-genetic BC111845.2 AAI11846.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q9H461.1 GenPept UniProtKB/Swiss-Prot:Q9H461

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