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    TRRAP transformation/transcription domain-associated protein [ Homo sapiens ]

    Gene ID: 8295, updated on 11-May-2012
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    Summary

    Official Symbol
    TRRAPprovided by HGNC
    Official Full Name
    transformation/transcription domain-associated proteinprovided by HGNC
    Primary source
    HGNC:12347
    See related
    Ensembl:ENSG00000196367; HPRD:04310; MIM:603015; Vega:OTTHUMG00000150403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Tra1; TR-AP; PAF400; STAF40; PAF350/400; FLJ10671
    Summary
    This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
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    Genomic context

    Location :
    7q21.2-q22.1
    Sequence :
    Chromosome: 7; NC_000007.13 (98476113..98610864)
    See TRRAP in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene neuronal pentraxin II Neighboring gene transmembrane protein 130 Neighboring gene microRNA 3609 Neighboring gene ring finger protein 14 pseudogene Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene karyopherin alpha 7 (importin alpha 8)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Xu B, et al. Nat Genet, 2011 Aug 7. PMID 21822266.
    4. Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Wei X, et al. Nat Genet, 2011 May. PMID 21499247.
    5. Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. Reitsma JM, et al. Cell Host Microbe, 2011 Feb 17. PMID 21320693.

    See all (77) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The over-expression of TRA1 in hepatocirrhosis and hepatocellular carcinoma is correlated with the formation and development of HCC.
      Title: [Expression and its clinicopathological features of tumor rejective antigen 1 in human tissues of hepatocellular carcinoma and liver cirrhosis].
    2. TRRAP harbors a recurrent mutation that clustered in one position (p. Ser722Phe) in 6 out of 167 melanoma samples (approx. 4%). The nature, pattern and functional evaluation of the TRRAP recurrent mutation suggest that TRRAP functions as an oncogene.
      Title: Exome sequencing identifies GRIN2A as frequently mutated in melanoma.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. knockdown of the adaptor protein TRRAP significantly increased differentiation of cultured brain tumor-initiating cells, sensitized the cells to apoptotic stimuli, and negatively affected cell cycle progression.
      Title: An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.
    5. Loss of Transduction; transformation-transcription domain-associated protein leads to a reduced level of beta-catenin ubiquitination, accumulation of beta-catenin protein and concomitant hyperactivation of the Wnt Proteins pathway.
      Title: HAT cofactor TRRAP mediates beta-catenin ubiquitination on the chromatin and the regulation of the canonical Wnt pathway.
    6. NPAT recruits the TRRAP-Tip60 complex to histone gene promoters to coordinate the transcriptional activation of multiple histone genes during the G(1)/S-phase transition
      Title: Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.
    7. Several function of TRRAP during cellular process like: DNA repair, cell cycle, transcription etc...
      Title: Orchestration of chromatin-based processes: mind the TRRAP.
    8. requirement in transcription activation via c-myc transformation domain
      Title: c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation.
    9. Data suggest a model in which p53 directly recruits a TRRAP/acetyltransferase complex to the mdm2 gene to activate transcription. In addition, this study defines a novel mechanism utilized by the p53 tumor suppressor to regulate gene expression.
      Title: Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.
    10. the multiple BRCA1 functions require a novel hGCN5/TRRAP histone acetyltransferase complex subclass
      Title: An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003487.1 NP_000116.1 ESR1    BIND  PubMed ESR1 (ER-alpha) interacts with TRRAP. This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and TRRAP from an unspecified species. 
    NP_003487.1 NP_002458.1 MYC    BIND  PubMed c-Myc interacts with TRRAP. 
    Q9Y4A5 O96019 ACTL6A    HPRD  PubMed  
    Q9Y4A5 O15265 ATXN7    HPRD  PubMed  
    Q9Y4A5 P38398 BRCA1    HPRD  PubMed  
    Q9Y4A5 Q9H0E9 BRD8    HPRD  PubMed  
    Q9Y4A5 Q9NV56 C20orf20    HPRD  PubMed  
    Q9Y4A5 Q01094 E2F1    HPRD  PubMed  
    Q9Y4A5 Q16254 E2F4    HPRD  PubMed  
    Q9Y4A5 Q96L91 EP400    HPRD  PubMed  
    Q9Y4A5 P03372 ESR1    HPRD  PubMed  
    Q9Y4A5 Q92830 KAT2A    HPRD  PubMed  
    Q9Y4A5 P61244 MAX    HPRD  PubMed  
    Q9Y4A5 P01106 MYC    HPRD  PubMed  
    BioGRID:113900 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:113900 BioGRID:112221 ATXN7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:121289 ATXN7L3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:113900 BioGRID:122818 C14orf169    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:120548 C20orf20    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:125213 CCDC101    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:107458 CDK8    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113900 BioGRID:121004 DMAP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:108206 E2F4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:121267 ENY2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:121676 EP400    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113900 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:120041 ING3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:113900 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:113900 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification 
    BioGRID:113900 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:111465 MED1    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:115293 MED12    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:115294 MED13    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:114699 MED14    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:119623 MED15    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:115342 MED16    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:114830 MED17    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:114829 MED23    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:115196 MED24    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:123607 MED25    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:114831 MED26    BioGRID  PubMed Co-purification 
    BioGRID:113900 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113900 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113900 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex 
    BioGRID:113900 BioGRID:201635 Myc    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:110924 NPAT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113900 BioGRID:114055 OFD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:124760 PYGO2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113900 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:112598 SREBF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113900 BioGRID:114042 SUPT3H    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:112744 TAF10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113900 BioGRID:112743 TAF9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113900 BioGRID:115223 TELO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113900 BioGRID:115030 TTI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113900 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113900 BioGRID:1678002 UL27    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113900 BioGRID:116914 USP22    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113900 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the TRRAP gene: The TRRAP gene is conserved in chimpanzee, , dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, and A.thaliana.
    • Map Viewer (Mouse)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription cofactor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H2A acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone acetylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    histone deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    PCAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    STAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    transformation/transcription domain-associated protein
    Names
    transformation/transcription domain-associated protein
    tra1 homolog
    350/400 kDa PCAF-associated factor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030010.1 RefSeqGene

      Range
      5001..139754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001244580.1 → NP_001231509.1  transformation/transcription domain-associated protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
      Source sequence(s)
      AC004893, AC004991, AF076974, AF110377, BQ006165
      UniProtKB/Swiss-Prot
      Q9Y4A5
      Conserved Domains (2) summary
      cd05163
      Location:3496 – 3783
      Blast Score: 767
      TRRAP; TRansformation/tRanscription domain-Associated Protein (TRRAP), pseudokinase domain; The TRRAP catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
      pfam02259
      Location:2851 – 3204
      Blast Score: 561
      FAT; FAT domain

    2. NM_003496.3 → NP_003487.1  transformation/transcription domain-associated protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC004991, AF076974, AF110377, BQ006165
      Consensus CDS
      CCDS5659.1
      UniProtKB/Swiss-Prot
      Q9Y4A5
      Related
      ENSP00000347733, OTTHUMP00000197293, ENST00000355540, OTTHUMT00000317979
      Conserved Domains (2) summary
      cd05163
      Location:3467 – 3754
      Blast Score: 767
      TRRAP; TRansformation/tRanscription domain-Associated Protein (TRRAP), pseudokinase domain; The TRRAP catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
      pfam02259
      Location:2833 – 3175
      Blast Score: 578
      FAT; FAT domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      98476113..98610864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571041.1 Reference GRCh37.p5 PATCHES

      Range
      247672..327275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      93109006..93243741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      97832168..97966885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004893.1 AAC62433.1
    genomic AC004991.1 AAC27675.2
    genomic CH236956.1 EAL23887.1
    genomic CH471091.2 EAW76693.1
      EAW76694.1
      EAW76695.1
      EAW76696.1
      EAW76697.1
      EAW76698.1
      EAW76699.1
      EAW76700.1
    mRNA AB209489.1 BAD92726.1
    mRNA AF076974.1 AAD09420.1
    mRNA AF110377.1 AAD04629.1
    mRNA AL050077.1 None
    mRNA BC032759.1 AAH32759.1
    mRNA BQ006165.1 None
    mRNA DA113420.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59FH1 GenPept UniProtKB/TrEMBL:Q59FH1
    Q9Y4A5.3 GenPept UniProtKB/Swiss-Prot:Q9Y4A5
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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