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AT4G30000 Dihydropterin pyrophosphokinase / Dihydropteroate synthase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829123, updated on 15-Oct-2023

Summary

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Gene symbol
AT4G30000
Gene description
Dihydropterin pyrophosphokinase / Dihydropteroate synthase
Primary source
Araport:AT4G30000
Locus tag
AT4G30000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F6G3.30; F6G3_30
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Genomic context

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See AT4G30000 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
2
Sequence:
Chromosome: 4; NC_003075.7 (14670156..14672669, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene fasciclin-like arabinogalactan protein Neighboring gene Leucine-rich repeat transmembrane protein kinase protein Neighboring gene ATP-dependent RNA helicase Neighboring gene PA-domain containing subtilase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam. Vadlamani G, et al. Plant Commun, 2022 Jul 11. PMID 35605193, Free PMC Article
  2. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article
  3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
  4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001203939.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydropteroate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
Dihydropterin pyrophosphokinase / Dihydropteroate synthase
NP_001190868.1
  • Dihydropterin pyrophosphokinase / Dihydropteroate synthase; FUNCTIONS IN: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity, dihydropteroate synthase activity; INVOLVED IN: pteridine and derivative metabolic process, cellular metabolic process, folic acid and derivative biosynthetic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (InterPro:IPR000550), Dihydropteroate synthase (InterPro:IPR006390), Pterin-binding (InterPro:IPR000489); BEST Arabidopsis thaliana protein match is: Dihydropterin pyrophosphokinase / Dihydropteroate synthase (TAIR:AT1G69190.1).
NP_194729.1
  • Dihydropterin pyrophosphokinase / Dihydropteroate synthase; FUNCTIONS IN: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity, dihydropteroate synthase activity; INVOLVED IN: pteridine and derivative metabolic process, cellular metabolic process, folic acid and derivative biosynthetic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (InterPro:IPR000550), Dihydropteroate synthase (InterPro:IPR006390), Pterin-binding (InterPro:IPR000489); BEST Arabidopsis thaliana protein match is: Dihydropterin pyrophosphokinase / Dihydropteroate synthase (TAIR:AT1G69190.1); Has 14894 Blast hits to 14858 proteins in 2526 species: Archae - 148; Bacteria - 9690; Metazoa - 8; Fungi - 166; Plants - 69; Viruses - 0; Other Eukaryotes - 4813 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    14670156..14672669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119146.3 → NP_194729.1  Dihydropterin pyrophosphokinase / Dihydropteroate synthase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194729.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JPH1, Q9SZV3
    UniProtKB/TrEMBL
    A0A178UTC5, A0A5S9XXJ9, A0A7G2F4W3
    Conserved Domains (2) summary
    cd00739
    Location:273 → 544
    DHPS; DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and ...
    pfam01288
    Location:90 → 215
    HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

  2. NM_001203939.1 → NP_001190868.1  Dihydropterin pyrophosphokinase / Dihydropteroate synthase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F4W3
    Conserved Domains (3) summary
    COG0294
    Location:267 → 545
    FolP; Dihydropteroate synthase [Coenzyme transport and metabolism]
    cd00739
    Location:273 → 541
    DHPS; DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and ...
    pfam01288
    Location:90 → 215
    HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SZV3.1

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