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HIST3H3 histone cluster 3, H3 [ Homo sapiens (human) ]

Gene ID: 8290, updated on 6-Jul-2014
Official Symbol
HIST3H3provided by HGNC
Official Full Name
histone cluster 3, H3provided by HGNC
Primary source
HGNC:4778
See related
Ensembl:ENSG00000168148; HPRD:04156; MIM:602820; Vega:OTTHUMG00000040044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H3t; H3.4; H3/g; H3FT
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
See HIST3H3 in Epigenomics, MapViewer
Location:
1q42
Exon count :
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (228424845..228425325, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228612546..228613026, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 11 Neighboring gene microRNA 6742 Neighboring gene tripartite motif containing 17 Neighboring gene ribosomal protein L23a pseudogene 15 Neighboring gene histone cluster 3, H2a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Rev, p19 rev HIV-1 Rev co-localizes with histone H3 in the nucleoplasmic compartment of cells PubMed
Tat, p14 tat Phosphorylation of serine 10 in histone H3 at the HIV promoter is increased in the presence of HIV-1 Tat PubMed
tat Purified recombinant Tat and Tat-derived synthetic peptides derived from the p300- and PCAF-binding sites in Tat inhibit histone H3/H4 acetylation in vitro PubMed
tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
histone H3.1t
Names
histone H3.1t
H3/t
histone 3, H3
H3 histone family, member T

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003493.2NP_003484.1  histone H3.1t

    See proteins identical to NP_003484.1

    Status: REVIEWED

    Source sequence(s)
    Z49861
    Consensus CDS
    CCDS1572.1
    UniProtKB/Swiss-Prot
    Q16695
    Related
    ENSP00000355657, OTTHUMP00000037945, ENST00000366696, OTTHUMT00000096595
    Conserved Domains (2) summary
    smart00428
    Location:34136
    Blast Score: 457
    H3; Histone H3
    PTZ00018
    Location:1136
    Blast Score: 649
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    228424845..228425325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    199127141..199127621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    229884858..229885338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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