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    CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 [ Homo sapiens ]

    Gene ID: 829, updated on 12-May-2012
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    Summary

    Official Symbol
    CAPZA1provided by HGNC
    Official Full Name
    capping protein (actin filament) muscle Z-line, alpha 1provided by HGNC
    Primary source
    HGNC:1488
    See related
    Ensembl:ENSG00000116489; HPRD:03347; MIM:601580; Vega:OTTHUMG00000011769
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPZ; CAZ1; CAPPA1
    Summary
    CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p13.2
    Sequence :
    Chromosome: 1; NC_000001.10 (113162075..113214241)
    See CAPZA1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 2B Neighboring gene suppression of tumorigenicity 7 like Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene Neighboring gene Mov10, Moloney leukemia virus 10, homolog (mouse) Neighboring gene ras homolog family member C

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. Fang Y, et al. Mol Cell Biochem, 2012 Jan. PMID 21800051.
    4. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Kato N, et al. Nat Genet, 2011 Jun. PMID 21572416.
    5. Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma. Sun D, et al. Melanoma Res, 2011 Aug. PMID 21566537.

    See all (33) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CAPAZA1 is over expressed in malignant melanoma.
      Title: Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.
    2. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management.
      Title: Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.
    3. Cd2 antigen is linked to this protein via CMS and CIN85.
      Title: Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.
    4. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein
      Title: The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.
    5. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein
      Title: V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P52907 P60709 ACTB    HPRD  PubMed  
    P52907 Q9Y5K6 CD2AP    HPRD  PubMed  
    P52907 P23297 S100A1    HPRD  PubMed  
    P52907 P04271 S100B    HPRD  PubMed  
    P52907 Q96B97 SH3KBP1    HPRD  PubMed  
    BioGRID:107279 BioGRID:117140 CD2AP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107279 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107279 BioGRID:112193 S100B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107279 BioGRID:116472 TWF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107279 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107279 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107279 BioGRID:119697 UIMC1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CAPZA1 gene: The CAPZA1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
      Advanced glycosylation endproduct receptor signaling, organism-specific biosystemAdvanced Glycosylation End- product-specific Receptor (AGER) also known as Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin supe...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cellular component movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    protein complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    F-actin capping protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    WASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    F-actin-capping protein subunit alpha-1
    Names
    F-actin-capping protein subunit alpha-1
    Cap Z
    capZ alpha-1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006135.2 → NP_006126.1  F-actin-capping protein subunit alpha-1

      Status: REVIEWED

      Source sequence(s)
      BC000144, DB233456
      Consensus CDS
      CCDS30805.1
      UniProtKB/Swiss-Prot
      P52907
      Related
      ENSP00000263168, OTTHUMP00000013512, ENST00000263168, OTTHUMT00000032567
      Conserved Domains (1) summary
      pfam01267
      Location:12 – 282
      Blast Score: 998
      F-actin_cap_A; F-actin capping protein alpha subunit

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      113162075..113214241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      111020785..111072609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL603832.28 CAI14054.1
    genomic AL929470.20 CAI16528.1
    genomic CH471122.1 EAW56525.1
      EAW56526.1
      EAW56527.1
    mRNA AJ227918.1 None
    mRNA AK223226.1 BAD96946.1
    mRNA AK289654.1 BAF82343.1
    mRNA BC000144.1 AAH00144.1
    mRNA BC034391.1 None
    mRNA BT019364.1 AAV38171.1
    mRNA BX648738.1 None
    mRNA CR407657.1 CAG28585.1
    mRNA CR541819.1 CAG46618.1
    mRNA DB233456.1 None
    mRNA U56637.1 AAC00533.1
    other-genetic DQ890754.2 ABM81680.1
    other-genetic DQ893919.2 ABM84845.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52907.3 GenPept UniProtKB/Swiss-Prot:P52907
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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