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ATMYC1 basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827965, updated on 7-Sep-2023

Summary

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Gene symbol
ATMYC1
Gene description
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Primary source
Araport:AT4G00480
Locus tag
AT4G00480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F6N23.22; F6N23_22; myc1
Summary
MYC-related protein with a basic helix-loop-helix motif at the C-terminus and a region similar to the maize B/R family at the N-terminus
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Genomic context

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Location:
chromosome: 4
Exon count:
8
Sequence:
Chromosome: 4; NC_003075.7 (216812..219926, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNA polymerase II transcription mediator Neighboring gene RHO guanyl-nucleotide exchange factor 3 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene beta-amylase 2 Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Acyl-CoA thioesterase family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a gene that encodes a MYC-related protein in Arabidopsis. Urao T, et al. Plant Mol Biol, 1996 Nov. PMID 8980509
  2. The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana. Song H, et al. Plant J, 2023 Apr. PMID 36721966
  3. Natural allelic variation defines a role for ATMYC1: trichome cell fate determination. Symonds VV, et al. PLoS Genet, 2011 Jun. PMID 21695236, Free PMC Article
  4. Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis. Pesch M, et al. Development, 2013 Aug. PMID 23900543
  5. A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis. Zhao H, et al. J Biol Chem, 2012 Apr 20. PMID 22334670, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana.
    Title: The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana.
  2. AtMYC1 protein is predominantly localised in the cytoplasm and can relocate GL1 from the nucleus into the cytoplasm.
    Title: Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis.
  3. AtMYC1 is an important regulator of trichome and root hair initiation
    Title: A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis.
  4. Natural allelic variation defines a role for ATMYC1: trichome cell fate determination
    Title: Natural allelic variation defines a role for ATMYC1: trichome cell fate determination.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001340255.1
NM_116272.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within trichome patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in root hair IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NP_001154194.1
  • ATMYC1; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G63650.3); Has 1481 Blast hits to 1090 proteins in 120 species: Archae - 0; Bacteria - 0; Metazoa - 3; Fungi - 0; Plants - 1462; Viruses - 0; Other Eukaryotes - 16 (source: NCBI BLink).
NP_191957.2
  • ATMYC1; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G63650.3); Has 1473 Blast hits to 1082 proteins in 120 species: Archae - 0; Bacteria - 0; Metazoa - 3; Fungi - 0; Plants - 1458; Viruses - 0; Other Eukaryotes - 12 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    216812..219926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160722.2 → NP_001154194.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154194.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FKM9, F4JHC4, F8UGN9, F8UGP2, F8UGQ1
    Conserved Domains (2) summary
    smart00353
    Location:346 → 388
    HLH; helix loop helix domain
    pfam14215
    Location:23 → 216
    bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

  2. NM_116272.4 → NP_191957.2  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191957.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65257, P93651, Q8W2F1
    UniProtKB/TrEMBL
    A0A654FKM9, C0SVG1, F8UGN9, F8UGP2, F8UGQ1
    Conserved Domains (2) summary
    smart00353
    Location:346 → 388
    HLH; helix loop helix domain
    pfam14215
    Location:23 → 216
    bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

  3. NM_001340255.1 → NP_001329692.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B8H4, A0A654FKM9, F8UGN9, F8UGP2, F8UGQ1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8W2F1.1

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