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MLH1 DNA mismatch repair protein MLH1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826493, updated on 4-Nov-2014
Gene symbol
MLH1
Gene description
DNA mismatch repair protein MLH1
Primary source
TAIR:AT4G09140
Locus tag
AT4G09140
Gene type
protein coding
RNA name
DNA mismatch repair protein MLH1
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA MUTL-HOMOLOGUE 1; ATMLH1; F23J3.170; F23J3_170; MLH1; MUTL-homologue 1
Summary
Encodes a protein with similarity to Mut1 DNA mismatch repair protein, from E.coli. The protein is expressed during prophase I of meiosis, colocalizes with MLH3 throughout pachytene and is dependent on MLH3 for proper localization.
See MLH1 in MapViewer
Location:
chromosome: 4
Exon count:
16
Sequence:
Chromosome: 4; NC_003075.7 (5816942..5821037, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene putative RING-H2 finger protein ATL36 Neighboring gene putative RING-H2 finger protein ATL37 Neighboring gene pseudo Neighboring gene pseudo

Homology

  • Homologs of the MLH1 gene: The MLH1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
NM_116983.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
mismatched DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding, bridging ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
ATP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA methylation RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
DNA-dependent DNA replication RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
chromatin modification RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
cotyledon development RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
double-strand break repair RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
double-strand break repair via homologous recombination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
embryo development ending in seed dormancy RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
embryo sac egg cell differentiation RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
fruit development IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene silencing by RNA RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
leaf development RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
meiotic DNA double-strand break formation RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
meiotic chromosome segregation RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitotic cell cycle RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic recombination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
pollen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pollen development RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
reciprocal meiotic recombination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of DNA replication RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of cell cycle RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of cell cycle process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
response to abscisic acid RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
seed development IMP
Inferred from Mutant Phenotype
more info
PubMed 
seed dormancy process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
seed germination IMP
Inferred from Mutant Phenotype
more info
PubMed 
seed germination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
sister chromatid cohesion RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
somatic cell DNA recombination RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
synapsis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
MutLalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
 
MutLbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
 
chiasma IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISM
Inferred from Sequence Model
more info
 
synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Names
DNA mismatch repair protein MLH1
NP_567345.2
  • MUTL-homologue 1 (MLH1); FUNCTIONS IN: protein binding, bridging; INVOLVED IN: in 6 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Mlh1 (InterPro:IPR011186), DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA mismatch repair protein, C-terminal (InterPro:IPR013507), DNA mismatch repair protein, N-terminal (InterPro:IPR014763), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA mismatch repair protein (InterPro:IPR002099), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721); BEST Arabidopsis thaliana protein match is: DNA mismatch repair protein, putative (TAIR:AT4G02460.1); Has 6802 Blast hits to 6727 proteins in 2342 species: Archae - 68; Bacteria - 4480; Metazoa - 469; Fungi - 496; Plants - 114; Viruses - 0; Other Eukaryotes - 1175 (source: NCBI BLink).

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 

    Range
    5816942..5821037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116983.2NP_567345.2  DNA mismatch repair protein MLH1 [Arabidopsis thaliana]

    See proteins identical to NP_567345.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZRV4
    Conserved Domains (3) summary
    TIGR00585
    Location:28338
    mutl; DNA mismatch repair protein MutL
    cd00075
    Location:51128
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cd03483
    Location:232358
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...