These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001146068.1 → NP_001139540.1 calpain-2 catalytic subunit isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
- Source sequence(s)
-
AB209855, AI089162, AK297800, BC011828, DA448245
- Consensus CDS
-
CCDS53478.1
- UniProtKB/TrEMBL
-
B4DN77
- UniProtKB/Swiss-Prot
-
P17655
- UniProtKB/TrEMBL
-
Q59EF6
- Related
- ENSP00000413158, ENST00000433674
- Conserved Domains (5) summary
-
- cd00044
Location:1 – 264
Blast Score: 899
- CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
- cd00051
Location:499 – 553
Blast Score: 97
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00214
Location:276 – 434
Blast Score: 539
- Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
- COG5126
Location:526 – 617
Blast Score: 95
- FRQ1; Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]
- pfam13833
Location:466 – 525
Blast Score: 93
- EF_hand_6; EF-hand domain pair
-
NM_001748.4 → NP_001739.2 calpain-2 catalytic subunit isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AB209855, AI089162, BC011828, DA448245
- Consensus CDS
-
CCDS31035.1
- UniProtKB/Swiss-Prot
-
P17655
- UniProtKB/TrEMBL
-
Q59EF6
- Related
- ENSP00000295006, OTTHUMP00000035497, ENST00000295006, OTTHUMT00000090973
- Conserved Domains (5) summary
-
- cd00044
Location:35 – 342
Blast Score: 1042
- CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
- cd00051
Location:577 – 631
Blast Score: 98
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00214
Location:354 – 512
Blast Score: 540
- Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
- COG5126
Location:604 – 695
Blast Score: 95
- FRQ1; Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]
- pfam13833
Location:544 – 603
Blast Score: 94
- EF_hand_6; EF-hand domain pair
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p10 Primary Assembly
Genomic
-
NC_000001.10 Reference GRCh37.p10 Primary Assembly
- Range
- 223889295..223963720
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000133.1 Alternate HuRef
- Range
- 194501759..194576134
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate CHM1_1.0
Genomic
-
NC_018912.1 Alternate CHM1_1.0
- Range
- 230684735..230759211
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)