EDS1 enhanced disease susceptibility 1 protein [Arabidopsis thaliana] - Gene

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Summary

Gene symbol: EDS1
Gene description: enhanced disease susceptibility 1 protein
Primary source: TAIR:AT3G48090
Locus tag: AT3G48090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATEDS1; EDS1; EDS1 PROTEIN; enhanced disease susceptibility 1
Summary: Component of R gene-mediated disease resistance in Arabidopsis thaliana with homology to eukaryotic lipases.

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Genomic context

Location :: chromosome: 3

Sequence :: Chromosome: 3; NC_003074.8 (17755374..17757780, complement)

See EDS1 in MapViewer

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that EDS1, PAD4, SAG101 function independently as well as in a ternary complex to mediate plant defense signaling
Title: SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus.
study shows EDS1 forms complexes with the TIR-NB-LRR resistance proteins RPS4 and RPS6 and the negative immune regulator SRFR1 at a cytoplasmic membrane
Title: Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators.
EDS1 molecularly connects TIR-NB-LRR disease resistance protein RPS4 recognition of bacterial effector AvrRps4 to defense pathways; EDS1 behaves as an effector target and activated TIR-NB-LRR signal transducer for defense across cell compartments
Title: Arabidopsis EDS1 connects pathogen effector recognition to cell compartment-specific immune responses.
An EDS1-PAD4 complex is necessary for basal resistance involving transcriptional up-regulation of PAD4 itself and mobilization of salicylic acid defenses.
Title: Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity.
Arabidopsis protein, EDS1, is an important regulator of innate immunity.
Title: Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101.
EDS1 regulates the response of the plant to chloroplast-derived O2*- by promoting salicylic acid-assisted accumulation of H2O2 as part of a mechanism restricting cell death.
Title: Salicylic acid antagonism of EDS1-driven cell death is important for immune and oxidative stress responses in Arabidopsis.
Differential susceptibility to PM is correlated with differences in EDS1 expression
Title: A functional EDS1 ortholog is differentially regulated in powdery mildew resistant and susceptible grapevines and complements an Arabidopsis eds1 mutant.
Analysis shows that nuclear accumulation of snc1 and the defense signaling components Enhanced Disease Susceptibility 1 and Nonexpresser of PR genes 1 is significantly reduced in mos7-1 plants, while nuclear retention of other proteins is unaffected.
Title: Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis.
EDS1 and salicylic acid act redundantly to regulate disease resistance.
Title: Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling.
Data suggest that the balanced activities of LSD1, EDS1, PAD4, and EIN2 regulate signaling of programmed cell death, light acclimation, and holistic defense responses that are initiated, at least in part, by redox changes of the plastoquinone pool.
Title: Chloroplast signaling and LESION SIMULATING DISEASE1 regulate crosstalk between light acclimation and immunity in Arabidopsis.

Submit: New GeneRIF Correction See all (17)

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
NP_190392.1	NP_190392.1	EDS1	BIND	PubMed	EDS1 interacts with another molecule of EDS1 to form a dimer.
NP_190392.1	NP_190811.1	PAD4	BIND	PubMed	EDS1 interacs with PAD4.
BioGRID:9283	BioGRID:9282	AT3G48080	BioGRID	PubMed	Affinity Capture-Western
BioGRID:9283	BioGRID:9283	EDS1	BioGRID	PubMed	FRET; Two-hybrid
BioGRID:9283	BioGRID:9438	LSU1	BioGRID	PubMed	Two-hybrid
BioGRID:9283	BioGRID:9726	PAD4	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
BioGRID:9283	BioGRID:19617	RPP8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:9283	BioGRID:19810	RPS4	BioGRID	PubMed	Affinity Capture-Western; PCA
BioGRID:9283	BioGRID:14584	RPS6	BioGRID	PubMed	Affinity Capture-Western; PCA
BioGRID:9283	BioGRID:16622	SAG101	BioGRID	PubMed	Affinity Capture-MS; Co-crystal Structure; Co-fractionation; FRET; Reconstituted Complex
BioGRID:9283	BioGRID:12690	SNC1	BioGRID	PubMed	Affinity Capture-Western; PCA
BioGRID:9283	BioGRID:15182	SRFR1	BioGRID	PubMed	Affinity Capture-Western; PCA

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General gene information

NM_001035752.1

Supported by ESTs:

NM_114678.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
lipase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
signal transducer activity	TAS Traceable Author Statement more info	PubMed
triglyceride lipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
aerenchyma formation	IMP Inferred from Mutant Phenotype more info	PubMed
defense response	ISS Inferred from Sequence or Structural Similarity more info
lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
response to singlet oxygen	IGI Inferred from Genetic Interaction more info	PubMed
systemic acquired resistance	IEP Inferred from Expression Pattern more info	PubMed
systemic acquired resistance, salicylic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

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General protein information

Names: enhanced disease susceptibility 1 protein

NP_001030829.1

enhanced disease susceptibility 1 (EDS1); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G48080.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_190392.1

enhanced disease susceptibility 1 (EDS1); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G48080.1); Has 536 Blast hits to 485 proteins in 45 species: Archae - 0; Bacteria - 4; Metazoa - 2; Fungi - 2; Plants - 491; Viruses - 0; Other Eukaryotes - 37 (source: NCBI BLink).

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8

Range

17755374..17757780, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114678.3 → NP_190392.1 enhanced disease susceptibility 1 protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

Q9SU72

Conserved Domains (1) summary

cd00519
Location:116 – 192
Blast Score: 160

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
NM_001035752.1 → NP_001030829.1 enhanced disease susceptibility 1 protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

B9DFM5

Conserved Domains (1) summary

cd00519
Location:8 – 84
Blast Score: 160

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	CP002686.1	AEE78366.1
genomic	EF470650.1	ABR45989.1
mRNA	AY046025.1	AAK76699.1
genomic	EF470654.1	ABR45993.1
mRNA	AY150423.1	AAN12884.1
genomic	AL049658.1	CAB41130.1
genomic	BA000014.8	CAB41130.1
genomic	EF470663.1	ABR46002.1
genomic	CP002686.1	AEE78367.1
mRNA	AK316830.1	BAH19542.1