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DUT1 DUTP-PYROPHOSPHATASE-LIKE 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823847, updated on 15-Oct-2023

Summary

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Gene symbol
DUT1
Gene description
DUTP-PYROPHOSPHATASE-LIKE 1
Primary source
Araport:AT3G46940
Locus tag
AT3G46940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DUTP-PYROPHOSPHATASE-LIKE 1; F13I12.6
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Genomic context

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Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_003074.8 (17288134..17289006, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene kinase superfamily with octicosapeptide/Phox/Bem1p domain-containing protein Neighboring gene Protein kinase superfamily protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene ncRNA Neighboring gene RNA helicase, ATP-dependent, SK12/DOB1 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into the mechanism defining substrate affinity in Arabidopsis thaliana dUTPase: the role of tryptophan 93 in ligand orientation. Inoguchi N, et al. BMC Res Notes, 2015 Dec 15. PMID 26666293, Free PMC Article
  2. Purification, crystallization and preliminary crystallographic analysis of deoxyuridine triphosphate nucleotidohydrolase from Arabidopsis thaliana. Bajaj M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 May 1. PMID 17565183, Free PMC Article
  3. The nucleotide metabolome of germinating Arabidopsis thaliana seeds reveals a central role for thymidine phosphorylation in chloroplast development. Niehaus M, et al. Plant Cell, 2022 Sep 27. PMID 35861422, Free PMC Article
  4. Homologous recombination is stimulated by a decrease in dUTPase in Arabidopsis. Dubois E, et al. PLoS One, 2011 Apr 26. PMID 21541310, Free PMC Article
  5. The SOS screen in Arabidopsis: a search for functions involved in DNA metabolism. Siaud N, et al. DNA Repair (Amst), 2010 May 4. PMID 20227352

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_114561.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dUTP diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dUMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dUTP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thymidine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DUTP-PYROPHOSPHATASE-LIKE 1
NP_190278.1
  • DUTP-PYROPHOSPHATASE-LIKE 1 (DUT1); FUNCTIONS IN: hydrolase activity, dUTP diphosphatase activity; INVOLVED IN: DNA repair, 2'-deoxyribonucleotide metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DeoxyUTP pyrophosphatase domain, subfamily 1, (InterPro:IPR008181), DeoxyUTP pyrophosphatase domain (InterPro:IPR008180); Has 7764 Blast hits to 7750 proteins in 2463 species: Archae - 14; Bacteria - 4311; Metazoa - 248; Fungi - 161; Plants - 56; Viruses - 831; Other Eukaryotes - 2143 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    17288134..17289006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001339288.1 → NP_001325766.1  DUTP-PYROPHOSPHATASE-LIKE 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LM85, A0A654FDH8

  2. NM_114561.4 → NP_190278.1  DUTP-PYROPHOSPHATASE-LIKE 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190278.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9STG6
    UniProtKB/TrEMBL
    A0A178VJ09
    Conserved Domains (1) summary
    PLN02547
    Location:2 → 166
    PLN02547; dUTP pyrophosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4OOP_A.1
4OOP_B.1
4OOP_C.1
4OOQ_A.1
4OOQ_B.1
4OOQ_C.1
Q9STG6.1

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