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TCP4 TCP family transcription factor 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820732, updated on 15-Feb-2024

Summary

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Gene symbol
TCP4
Gene description
TCP family transcription factor 4
Primary source
Araport:AT3G15030
Locus tag
AT3G15030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
maternal effect embryo arrest 35; MEE35; TCP family transcription factor 4
Summary
Arabidopsis thaliana TCP family transcription factor. Regulated by miR319. Involved in heterchronic regulation of leaf differentiation.
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Genomic context

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Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_003074.8 (5061681..5064152)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cobalt ion binding protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Lactate/malate dehydrogenase family protein Neighboring gene senescence regulator (Protein of unknown function, DUF584) Neighboring gene IQ-domain 10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Transcription Factors TCP4 and PIF3 Antagonistically Regulate Organ-Specific Light Induction of SAUR Genes to Modulate Cotyledon Opening during De-Etiolation in Arabidopsis. Dong J, et al. Plant Cell, 2019 May. PMID 30914467, Free PMC Article
  2. The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways. Challa KR, et al. PLoS Genet, 2019 Feb. PMID 30742619, Free PMC Article
  3. Interaction of TCP4-mediated growth module with phytohormones. Sarvepalli K, et al. Plant Signal Behav, 2011 Oct. PMID 21904111, Free PMC Article
  4. The TCP4 transcription factor of Arabidopsis blocks cell division in yeast at G1→S transition. Aggarwal P, et al. Biochem Biophys Res Commun, 2011 Jul 1. PMID 21658370
  5. Hyper-activation of the TCP4 transcription factor in Arabidopsis thaliana accelerates multiple aspects of plant maturation. Sarvepalli K, et al. Plant J, 2011 Aug. PMID 21518050

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis TCP4 transcription factor inhibits high temperature-induced homeotic conversion of ovules.
    Title: Arabidopsis TCP4 transcription factor inhibits high temperature-induced homeotic conversion of ovules.
  2. The function of the WRI1-TCP4 regulatory module in lipid biosynthesis.
    Title: The function of the WRI1-TCP4 regulatory module in lipid biosynthesis.
  3. TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to Mediate Seed Oil Biosynthesis.
    Title: TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to Mediate Seed Oil Biosynthesis.
  4. De Novo Shoot Regeneration Controlled by HEN1 and TCP3/4 in Arabidopsis.
    Title: De Novo Shoot Regeneration Controlled by HEN1 and TCP3/4 in Arabidopsis.
  5. The TCP4 Transcription Factor Directly Activates TRICHOMELESS1 and 2 and Suppresses Trichome Initiation.
    Title: The TCP4 Transcription Factor Directly Activates TRICHOMELESS1 and 2 and Suppresses Trichome Initiation.
  6. The study reveals that the interplay between light-responsive factors PIFs and the developmental regulator TCP4 determines the cotyledon-specific light regulation of SAUR16 and SAUR50, which contributes to cotyledon closure and opening before and after de-etiolation.
    Title: The Transcription Factors TCP4 and PIF3 Antagonistically Regulate Organ-Specific Light Induction of SAUR Genes to Modulate Cotyledon Opening during De-Etiolation in Arabidopsis.
  7. We induced a microRNA-resistant form of TCP4 at various developmental stages of leaf primordium that lacked the activity of TCP4 and its homologues and followed its effect on growth kinematics. By combining this with spatio-temporal gene expression analysis, we show that TCP4 commits leaf cells within the transition zone to exit proliferation and enter differentiation.
    Title: The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways.
  8. Detailed genetic analyses show that GIS and TCP4 work in same pathway and GIS function is required for TCP4-mediated regulation of trichome differentiation.
    Title: The TCP4 transcription factor regulates trichome cell differentiation by directly activating GLABROUS INFLORESCENCE STEMS in Arabidopsis thaliana.
  9. Mutations in MIR319 and gain-of-function mutations in the TCP4 gene conferred resistance against miR319 and impaired the cotyledon boundary and leaf serration formation. Taken together, these findings demonstrate that the MIR319 and TCP gene families underlie robust and multilayer control of leaf development.
    Title: Roles of miR319 and TCP Transcription Factors in Leaf Development.
  10. miR319 and its target TCP4 can act as switches that turn on secondary cell wall synthesis and programmed cell death.
    Title: Activation of secondary cell wall biosynthesis by miR319-targeted TCP4 transcription factor.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001202967.1
NM_001338148.1
NM_112365.4
NM_180258.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cotyledon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cotyledon morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within leaf development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within leaf morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within leaf senescence IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of development, heterochronic IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
TCP family transcription factor 4
NP_001189896.1
  • TCP family transcription factor 4 (TCP4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, TCP (InterPro:IPR005333), Transcription factor TCP subgroup (InterPro:IPR017887); BEST Arabidopsis thaliana protein match is: TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3 (TAIR:AT1G53230.1).
NP_001319557.1
  • TCP family transcription factor 4 (TCP4); CONTAINS InterPro DOMAIN/s: Transcription factor, TCP (InterPro:IPR005333), Transcription factor TCP subgroup (InterPro:IPR017887); BEST Arabidopsis thaliana protein match is: TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3 (TAIR:AT1G53230.1); Has 1577 Blast hits to 1575 proteins in 330 species: Archae - 0; Bacteria - 0; Metazoa - 88; Fungi - 13; Plants - 1470; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).
NP_850589.1
  • TCP family transcription factor 4 (TCP4); CONTAINS InterPro DOMAIN/s: Transcription factor, TCP (InterPro:IPR005333), Transcription factor TCP subgroup (InterPro:IPR017887); BEST Arabidopsis thaliana protein match is: TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3 (TAIR:AT1G53230.1); Has 1577 Blast hits to 1575 proteins in 330 species: Archae - 0; Bacteria - 0; Metazoa - 88; Fungi - 13; Plants - 1470; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5061681..5064152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001338148.1 → NP_001319557.1  TCP family transcription factor 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
    UniProtKB/TrEMBL
    A0A384KY84, A0A654F7B2
    Conserved Domains (1) summary
    cl23822
    Location:43 → 104
    TCP; TCP family transcription factor

  2. NM_112365.4 → NP_188121.1  TCP family transcription factor 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188121.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
    UniProtKB/TrEMBL
    A0A384KY84, A0A654F7B2
    Conserved Domains (1) summary
    cl23822
    Location:43 → 104
    TCP; TCP family transcription factor

  3. NM_001202967.1 → NP_001189896.1  TCP family transcription factor 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189896.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
    UniProtKB/TrEMBL
    A0A384KY84, A0A654F7B2
    Conserved Domains (1) summary
    cl23822
    Location:43 → 104
    TCP; TCP family transcription factor

  4. NM_180258.3 → NP_850589.1  TCP family transcription factor 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850589.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
    UniProtKB/TrEMBL
    A0A384KY84, A0A654F7B2
    Conserved Domains (1) summary
    cl23822
    Location:43 → 104
    TCP; TCP family transcription factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LPR5.1

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