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    NRIP1 nuclear receptor interacting protein 1 [ Homo sapiens ]

    Gene ID: 8204, updated on 20-May-2012
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    Summary

    Official Symbol
    NRIP1provided by HGNC
    Official Full Name
    nuclear receptor interacting protein 1provided by HGNC
    Primary source
    HGNC:8001
    See related
    Ensembl:ENSG00000180530; HPRD:03927; MIM:602490; Vega:OTTHUMG00000074323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIP140; FLJ77253
    Summary
    Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    21q11.2
    Sequence :
    Chromosome: 21; NC_000021.8 (16333556..16437126, complement)
    See NRIP1 in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 16 Neighboring gene RNA binding motif protein, X-linked 2 pseudogene 1 Neighboring gene uncharacterized LOC100652984 Neighboring gene cytochrome c, somatic pseudogene 42

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH analysis in a Ph+ ALL patient. Zhang R, et al. Cancer Genet, 2011 Dec. PMID 22285022.
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    3. Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140. Madak-Erdogan Z, et al. Toxicol Sci, 2012 Feb. PMID 22071320.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (81) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Highlight the importance of cross-regulation between AhR and ERalpha and a novel mechanism by which AhR controls, through modulating the recruitment of RIP140 to ERalpha-binding sites, the kinetics and magnitude of ERalpha-mediated gene stimulation.
      Title: Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140.
    2. The fusion of NRIP1 with UHRF1 involved in the unbalanced translocation between chromosomes 19 and 21 in a patient with an ALL-positive for a t(9;22) translocation.
      Title: A possible 5'-NRIP1/UHRF1-3' fusion gene detected by array CGH analysis in a Ph+ ALL patient.
    3. Decreased RIP140 protein content not required for exercise and AMPK-dependent increases in skeletal muscle mitochondrial content.
      Title: Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content.
    4. We demonstrate that NRIP is a novel binding protein for human papillomavirus 16 (HPV-16) E2 protein and directly interacts with the TAD of HPV-16 E2.
      Title: NRIP, a novel calmodulin binding protein, activates calcineurin to dephosphorylate human papillomavirus E2 protein.
    5. This study shows that RIP140 is a regulator of the E2F pathway, which discriminates luminal- and basal-like tumors, emphasizing the importance of these regulations for a clinical cancer phenotype.
      Title: The transcriptional coregulator RIP140 represses E2F1 activity and discriminates breast cancer subtypes.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. RIP140 transgenic mice, expressing increased levels of RIP140 mRNA/protein in the heart, exhibit rapid and progressive postnatal cardiomyopathy leading to premature death predominantly owing to compromised energy production.
      Title: Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function.
    8. Receptor-interacting protein 140 (RIP140) is a corepressor for nuclear receptors with an important role in the inhibition of energy expenditure.
      Title: RIP140 gene and protein expression levels are downregulated in visceral adipose tissue in human morbid obesity.
    9. Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex.
      Title: Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex.
    10. The RIP140 gene does not play a pivotal role in the process of ovulation, insulin resistance, or fat accumulation in women with PCOS.
      Title: Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome.
    Submit: New GeneRIF Correction See all (22)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000021.7 NP_000116.2 ESR1    BIND  PubMed ER interacts with NRIP-1 enhancer. 
    NC_000021.7 NP_004487.2 FOXA1    BIND  PubMed FOXA1 interacts with NRIP-1 enhancer. 
    NC_000021.7 NP_000928.1 POLR2A    BIND  PubMed Pol II interacts with NRIP-1 enhancer. 
    NP_003480.2 NP_000116.1 ESR1    BIND  PubMed ESR1 (ER-alpha) interacts with NRIP1 (RIP140). This interaction was modelled on a demonstrated interaction between human ESR1 and mouse NRIP1. 
    P48552 P35609 ACTN2    HPRD  PubMed  
    P48552 P35869 AHR    HPRD  PubMed  
    P48552 P10275 AR    HPRD  PubMed  
    P48552 Q15834 CCDC85B    HPRD  PubMed  
    P48552 Q8NHQ1 CEP70    HPRD  PubMed  
    P48552 Q13363 CTBP1    HPRD  PubMed  
    P48552 P56545 CTBP2    HPRD  PubMed  
    P48552 P03372 ESR1    HPRD  PubMed  
    P48552 Q92731 ESR2    HPRD  PubMed  
    P48552 P62508 ESRRG    HPRD  PubMed  
    P48552 Q13547 HDAC1    HPRD  PubMed  
    P48552 Q92769 HDAC2    HPRD  PubMed  
    P48552 O15379 HDAC3    HPRD  PubMed  
    P48552 Q9UQL6 HDAC5    HPRD  PubMed  
    P48552 P41235 HNF4A    HPRD  PubMed  
    P48552 P05412 JUN    HPRD  PubMed  
    P48552 Q92831 KAT2B    HPRD  PubMed  
    P48552 O95751 LDOC1    HPRD  PubMed  
    P48552 O43318 MAP3K7    HPRD  PubMed  
    P48552 P51843 NR0B1    HPRD  PubMed  
    P48552 P55055 NR1H2    HPRD  PubMed  
    P48552 Q13133 NR1H3    HPRD  PubMed  
    P48552 P13056 NR2C1    HPRD  PubMed  
    P48552 P04150 NR3C1    HPRD  PubMed  
    P48552 Q13285 NR5A1    HPRD  PubMed  
    P48552 O00482 NR5A2    HPRD  PubMed  
    P48552 Q07869 PPARA    HPRD  PubMed  
    P48552 Q03181 PPARD    HPRD  PubMed  
    P48552 P37231 PPARG    HPRD  PubMed  
    P48552 Q99873 PRMT1    HPRD  PubMed  
    P48552 P10276 RARA    HPRD  PubMed  
    P48552 Q92753 RORB    HPRD  PubMed  
    P48552 P19793 RXRA    HPRD  PubMed  
    P48552 P28702 RXRB    HPRD  PubMed  
    P48552 TEX11 TEX11    HPRD  PubMed  
    P48552 P37243 THRB    HPRD  PubMed  
    P48552 Q92956 TNFRSF14    HPRD  PubMed  
    P48552 Q12933 TRAF2    HPRD  PubMed  
    P48552 P11473 VDR    HPRD  PubMed  
    P48552 Q04917 YWHAH    HPRD  PubMed  
    BioGRID:113843 BioGRID:106603 ACTN2    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:106699 AHR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113843 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113843 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:123234 CEP70    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:115774 CIB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113843 BioGRID:107870 CTBP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113843 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113843 BioGRID:108403 ESR1    BioGRID  PubMed Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113843 BioGRID:108404 ESR2    BioGRID  PubMed FRET; Two-hybrid 
    BioGRID:113843 BioGRID:108405 ESRRA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113843 BioGRID:108406 ESRRB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:108407 ESRRG    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113843 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113843 BioGRID:115331 HDAC5    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:113843 BioGRID:115083 HDAC9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:109414 HNF4A    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:109928 JUN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:110035 KPNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113843 BioGRID:117169 LDOC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:106695 NR0B1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113843 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:115373 NR1H3    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113843 BioGRID:108792 NR5A1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113843 BioGRID:108772 NR5A2    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:111461 PPARA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:111464 PPARG    BioGRID  PubMed FRET; Reconstituted Complex 
    BioGRID:113843 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113843 BioGRID:247775 Ppara    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113843 BioGRID:112023 RORB    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:112168 RXRA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:112169 RXRB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:202586 Rara    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:203039 Rxrb    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113843 BioGRID:121093 TEX11    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:112923 THRA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113843 BioGRID:112924 THRB    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:113038 TRAF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113843 BioGRID:113264 VDR    BioGRID  PubMed Two-hybrid 
    BioGRID:113843 BioGRID:113348 XPO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113843 BioGRID:116168 YWHAQ    BioGRID  PubMed Co-localization; Phenotypic Suppression; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    glucocorticoid receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    retinoid X receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ovarian follicle rupture IEA
    Inferred from Electronic Annotation
    more info
    		  
    ovulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    histone deacetylase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    nuclear receptor-interacting protein 1
    Names
    nuclear receptor-interacting protein 1
    nuclear factor RIP140
    receptor interacting protein 140
    receptor-interacting protein 140
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003489.3 → NP_003480.2  nuclear receptor-interacting protein 1

      Status: REVIEWED

      Source sequence(s)
      AF127577, AK289786, BC040361
      Consensus CDS
      CCDS13568.1
      UniProtKB/TrEMBL
      A8K171
      UniProtKB/Swiss-Prot
      P48552
      Related
      ENSP00000327213, ENST00000318948

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p5 Primary Assembly

      Range
      16333556..16437126, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      1716336..1819597, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF127577.2 AAF35255.1
    genomic AF248484.1 AAF62185.1
    genomic AL163207.2 CAB90396.1
    genomic CH471079.2 EAX10047.1
    mRNA AK123818.1 None
    mRNA AK289786.1 BAF82475.1
    mRNA BC040361.1 AAH40361.1
    mRNA BE792046.1 None
    mRNA X84373.1 CAA59108.1
    other-genetic DQ891180.2 ABM82106.1
    other-genetic DQ894362.2 ABM85288.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48552.2 GenPept UniProtKB/Swiss-Prot:P48552
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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