NCOA3 nuclear receptor coactivator 3 [ Homo sapiens ]

Gene ID: 8202, updated on 5-Feb-2012

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Summary

Official Symbol: NCOA3provided by HGNC
Official Full Name: nuclear receptor coactivator 3provided by HGNC
Primary source: HGNC:7670
Locus tag: RP5-1049G16.3
See related: Ensembl:ENSG00000124151; HPRD:03570; MIM:601937; Vega:OTTHUMG00000033061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
Summary: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

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Genomic context

Location :: 20q12

Sequence :: Chromosome: 20; NC_000020.10 (46130601..46285621)

See NCOA3 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results reveal DRO1 as an AIB1-targeted tumor suppressor, providing a novel mechanism for AIB1-dependent inhibition of apoptosis.
Title: Transcriptional repression of the tumor suppressor DRO1 by AIB1.
both 53BP1 and SRC3 have a common function that converge at the BRCA1 promoter and possibly other genes important for DNA repair and genomic stability
Title: Regulation of the BRCA1 gene by an SRC3/53BP1 complex.
SPOP expression inhibited SRC-3-mediated oncogenic signaling and tumorigenesis.
Title: Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.
crucial role for SRC-3 in regulating hepatic lipid metabolism
Title: Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis.
a model whereby the transcriptional activity of AIB1 is squelched by a repressive mechanism utilizing the N-terminal domain and that the increased coactivator function of AIB1-Delta4 is due to the loss of this inhibitory domain
Title: Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription.
The influence of the two NCOA3 variants on breast cancer risk by genotyping an Australian case-control study population, was investigated.
Title: Investigation of the 1758G>C and 2880A>G variants within the NCOA3 gene in a breast cancer affected Australian population.
The increase of NCOA3 is essential for SYT-SSX1-mediated synovial sarcoma formation. SYT-SSX1 does so by increasing the sumoylation of NCOA3 through interaction with a SUMO E3 ligase, PIASy, as well as the sumoylation of NEMO.
Title: SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein.
results confirm that AIB1 poly-Q repeat length polymorphism does not influence the BC risk in general but suggest that the specific AIB1 genotypes should be considered in patients with BC carrying mutation in the BRCA1/2 genes.
Title: The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development.
Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.
Title: Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.
HOXC8 blocks the AR-dependent recruitment of the steroid receptor coactivators steroid receptor coactivator-3 (SRC-3)
Title: HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes.

Submit: New GeneRIF Correction See all (100)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex	PubMed
	tat	p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
AAB92368.1	NP_004371.1	CREBBP	BIND	PubMed	ACTR interacts with CBP. This interaction was modeled on a demonstrated interaction between human ACTR and CBP from an unspecified species.
AAB92368.1	NP_004947.2	ETV1	BIND	PubMed	ACTR interacts with ER81.
AAB92368.1	NP_002948.1	RXRA	BIND	PubMed	ACTR interacts with RXR.
AAB92368.1	NP_000452.2	THRB	BIND	PubMed	ACTR interacts with TR.
AAB92368.1	NP_000367.1	VDR	BIND	PubMed	ACTR interacts with VDR.
AAC51663.1	NP_005027.2	PPARA	BIND	PubMed	RAC3 interacts with PPAR-alpha. This interaction was modelled on a demonstrated interaction between human RAC3 and mouse PPAR-alpha.
AAC51663.1	NP_000955.1	RARA	BIND	PubMed	RAC3 interacts with RAR-alpha.
NP_006525.2	NP_954592.1	CARM1	BIND	PubMed	SRC-3 interacts with CARM1. This interaction was modelled on a demonstrated interaction between human SRC-3 and CARM1 from an unspecified species.
NP_006525.2	NP_004371.1	CREBBP	BIND	PubMed	SRC-3 interacts with CBP. This interaction was modelled on a demonstrated interaction between human SRC-3 and CBP from an unspecified species.
NP_006525.2	NP_005216.1	E2F1	BIND	PubMed	ACTR interacts with E2F1.
NP_006525.2	NP_000116.1	ESR1	BIND	PubMed	SRC-3 interacts with ER. This interaction was modelled on a demonstrated interaction between human SRC-3 and ER from an unspecified species.
NP_006525.2	NP_002084.2	GSK3B	BIND	PubMed	SRC-3 interacts with and is phosphorylated by GSK3-beta.
NP_006525.2	NP_068810.2	RELA	BIND	PubMed	SRC-3 interacts with NF-kappa-B.
NP_858045.1	NP_004371.1	CREBBP	BIND	PubMed	CBP interacts with TRAM-1. This interaction was modelled on a demonstrated interaction between mouse CBP and human TRAM-1.
NP_858045.1	NP_000116.1	ESR1	BIND	PubMed	TRAM-1 interacts with ER.
NP_858045.1	NP_003875.3	KAT2B	BIND	PubMed	P/CAF interacts with TRAM-1.
NP_858045.1	NP_068811.1	RXRB	BIND	PubMed	TRAM-1 interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and mouse RXR-beta.
NP_858045.1	NP_000452.2	THRB	BIND	PubMed	TRAM-1 interacts with TR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and rat TR-beta.
NP_858045.1			BIND	PubMed	TRAM-1 interacts with THR-beta-RXR-beta complex. This interaction was modelled on a demonstrated interaction between human TRAM-1 and a complex of rat TR-beta and mouse RXR-beta.
Q9Y6Q9	P10275	AR	HPRD	PubMed
Q9Y6Q9	P22004	BMP6	HPRD	PubMed
Q9Y6Q9	P18075	BMP7	HPRD	PubMed
Q9Y6Q9	P24385	CCND1	HPRD	PubMed
Q9Y6Q9	O15111	CHUK	HPRD	PubMed
Q9Y6Q9	Q92793	CREBBP	HPRD	PubMed
Q9Y6Q9	Q92841	DDX17	HPRD	PubMed
Q9Y6Q9	P17844	DDX5	HPRD	PubMed
Q9Y6Q9	Q01094	E2F1	HPRD	PubMed
Q9Y6Q9	Q09472	EP300	HPRD	PubMed
Q9Y6Q9	P03372	ESR1	HPRD	PubMed
Q9Y6Q9	Q92731	ESR2	HPRD	PubMed
Q9Y6Q9	P11474	ESRRA	HPRD	PubMed
Q9Y6Q9	O95718	ESRRB	HPRD	PubMed
Q9Y6Q9	Q00403	GTF2B	HPRD	PubMed
Q9Y6Q9	O14920	IKBKB	HPRD	PubMed
Q9Y6Q9	Q9Y6K9	IKBKG	HPRD	PubMed
Q9Y6Q9	P05412	JUN	HPRD	PubMed
Q9Y6Q9	Q92831	KAT2B	HPRD	PubMed
Q9Y6Q9	P28482	MAPK1	HPRD	PubMed
Q9Y6Q9	Q16539	MAPK14	HPRD	PubMed
Q9Y6Q9	Q96T76	MMS19	HPRD	PubMed
Q9Y6Q9	Q9Y6Q9	NCOA3	HPRD	PubMed
Q9Y6Q9	Q9Y618	NCOR2	HPRD	PubMed
Q9Y6Q9	Q99743	NPAS2	HPRD	PubMed
Q9Y6Q9	P55055	NR1H2	HPRD	PubMed
Q9Y6Q9	Q13133	NR1H3	HPRD	PubMed
Q9Y6Q9	O75469	NR1I2	HPRD	PubMed
Q9Y6Q9	P22736	NR4A1	HPRD	PubMed
Q9Y6Q9	P06401	PGR	HPRD	PubMed
Q9Y6Q9	Q13526	PIN1	HPRD	PubMed
Q9Y6Q9	P37231	PPARG	HPRD	PubMed
Q9Y6Q9	Q99873	PRMT1	HPRD	PubMed
Q9Y6Q9	P28065	PSMB9	HPRD	PubMed
Q9Y6Q9	P61289	PSME3	HPRD	PubMed
Q9Y6Q9	P10276	RARA	HPRD	PubMed
Q9Y6Q9	P10826	RARB	HPRD	PubMed
Q9Y6Q9	P13631	RARG	HPRD	PubMed
Q9Y6Q9	Q04206	RELA	HPRD	PubMed
Q9Y6Q9	P19793	RXRA	HPRD	PubMed
Q9Y6Q9	P28702	RXRB	HPRD	PubMed
Q9Y6Q9	Q969G3	SMARCE1	HPRD	PubMed
Q9Y6Q9	Q9UMX1	SUFU	HPRD	PubMed
Q9Y6Q9	P63165	SUMO1	HPRD	PubMed
Q9Y6Q9	P20226	TBP	HPRD	PubMed
Q9Y6Q9	P37243	THRB	HPRD	PubMed
Q9Y6Q9	Q04917	YWHAH	HPRD	PubMed
BioGRID:113841	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113841	BioGRID:106573	ACTA1	BioGRID	PubMed	Affinity Capture-MS
	AAS45544.1	ANKRD11	BIND	PubMed	ANCO-1 interacts with RAC3.
BioGRID:113841	BioGRID:118888	ANKRD11	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:106799	ANXA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:106862	AR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:118827	ATAD2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:107140	BRCA1	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide; Reconstituted Complex
BioGRID:113841	BioGRID:114946	BRE	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:115760	CARM1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-fractionation; Co-purification; Reconstituted Complex
	NC_000011.8	CCND1	BIND	PubMed	AIB1 interacts with cyclin D1 promoter.
BioGRID:113841	BioGRID:107067	CCND1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:107467	CDKN3	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:107569	CHUK	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:113841	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:107838	CSNK1E	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:113841	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:113841	BioGRID:115913	DCTN6	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:115776	DDX17	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:108021	DDX5	BioGRID	PubMed	Phenotypic Enhancement; Reconstituted Complex
	NC_000008.9	EBAG9	BIND	PubMed	AIB1 interacts with EBAG9 promoter.
BioGRID:113841	BioGRID:109857	EIF3E	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
	NC_000017.9	ERBB2	BIND	PubMed	NCOA3 (AIB1) interacts with the ERBB2 (HER2) promoter.
BioGRID:113841	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:108404	ESR2	BioGRID	PubMed	FRET; Reconstituted Complex
BioGRID:113841	BioGRID:108405	ESRRA	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:108406	ESRRB	BioGRID	PubMed	Reconstituted Complex
	NP_005229.1	ETS1	BIND	PubMed	NCOA3 (AIB1) interacts with ETS1.
BioGRID:113841	BioGRID:108414	ETS1	BioGRID	PubMed	Affinity Capture-Western
	NP_005230.1	ETS2	BIND	PubMed	NCOA3 (AIB1) interacts with ETS2.
BioGRID:113841	BioGRID:108415	ETS2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:108636	FOS	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113841	BioGRID:109187	GSK3B	BioGRID	PubMed	Biochemical Activity
BioGRID:113841	BioGRID:113895	HIST3H3	BioGRID	PubMed	Biochemical Activity
BioGRID:113841	BioGRID:125732	HIST4H4	BioGRID	PubMed	Biochemical Activity
BioGRID:113841	BioGRID:109767	IKBKB	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-fractionation; Reconstituted Complex
BioGRID:113841	BioGRID:114089	IKBKG	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:113841	BioGRID:125852	IQCK	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:114375	KAT2B	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:111580	MAPK1	BioGRID	PubMed	Biochemical Activity
BioGRID:113841	BioGRID:107819	MAPK14	BioGRID	PubMed	Biochemical Activity
BioGRID:113841	BioGRID:111585	MAPK8	BioGRID	PubMed	Biochemical Activity
BioGRID:113841	BioGRID:116547	MORC2	BioGRID	PubMed	Affinity Capture-MS
	NC_000008.9	MYC	BIND	PubMed	AIB1 interacts with c-myc promoter.
BioGRID:113841	BioGRID:110712	MYH9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:114200	NCOA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:115761	NCOA2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:113841	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113841	BioGRID:114974	NCOR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113841	BioGRID:110848	NFATC3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:112936	NKX2-1	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:110923	NPAS2	BioGRID	PubMed	Reconstituted Complex
BioGRID:113841	BioGRID:114012	NR0B2	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:113222	NR1H2	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:115373	NR1H3	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:112883	NR2F1	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:109165	NR3C1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113841	BioGRID:109407	NR4A1	BioGRID	PubMed	Reconstituted Complex
	NP_995582.1	NR5A2	BIND	PubMed	NR5A2 interacts with an unspecified isoform of NCOA3.
BioGRID:113841	BioGRID:108772	NR5A2	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:201839	Nr1i2	BioGRID	PubMed	Reconstituted Complex
BioGRID:113841	BioGRID:111260	PGR	BioGRID	PubMed	Reconstituted Complex
BioGRID:113841	BioGRID:111464	PPARG	BioGRID	PubMed	FRET; Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:109512	PRMT1	BioGRID	PubMed	Reconstituted Complex
BioGRID:113841	BioGRID:115492	PSME3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:111849	RARA	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:111851	RARG	BioGRID	PubMed	Two-hybrid
BioGRID:113841	BioGRID:115301	RBX1	BioGRID	PubMed	Biochemical Activity
BioGRID:113841	BioGRID:112168	RXRA	BioGRID	PubMed	Co-localization; Reconstituted Complex
BioGRID:113841	BioGRID:110262	SMAD2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:113993	SPOP	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:112586	SPTA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:115329	SRA1	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:113841	BioGRID:112655	STAT6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:112923	THRA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113841	BioGRID:112924	THRB	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:113028	TPR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:112615	TRIM21	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113841	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113841	BioGRID:113264	VDR	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:113841	BioGRID:116168	YWHAQ	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
androgen receptor binding	NAS Non-traceable Author Statement more info	PubMed
chromatin binding	IEA Inferred from Electronic Annotation more info
estrogen receptor binding	IEA Inferred from Electronic Annotation more info
histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
ligand-dependent nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
ligand-dependent nuclear receptor transcription coactivator activity	IEA Inferred from Electronic Annotation more info
nuclear hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
protein N-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info
thyroid hormone receptor binding	NAS Non-traceable Author Statement more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
transcription coactivator activity	NAS Non-traceable Author Statement more info	PubMed
transferase activity, transferring acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
androgen receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
cellular lipid metabolic process	TAS Traceable Author Statement more info
developmental growth	IEA Inferred from Electronic Annotation more info
histone acetylation	IDA Inferred from Direct Assay more info	PubMed
mammary gland branching involved in thelarche	IEA Inferred from Electronic Annotation more info
multicellular organism growth	IEA Inferred from Electronic Annotation more info
positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
receptor transactivation	TAS Traceable Author Statement more info	PubMed
regulation of RNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info
vagina development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: nuclear receptor coactivator 3

Names: nuclear receptor coactivator 3; CBP-interacting protein; receptor-associated coactivator 3; amplified in breast cancer 1 protein; steroid receptor coactivator protein 3; class E basic helix-loop-helix protein 42; thyroid hormone receptor activator molecule 1

NP_001167558.1

EC 2.3.1.48

NP_001167559.1

EC 2.3.1.48

NP_006525.2

EC 2.3.1.48

NP_858045.1

EC 2.3.1.48

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016810.1 RefSeqGene

Range

5001..160021

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001174087.1 → NP_001167558.1 nuclear receptor coactivator 3 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.

Source sequence(s)

AB209863, AL034418, DB091786

UniProtKB/TrEMBL

Q59EE8

Conserved Domains (5) summary

cd00130
Location:121 – 186
Blast Score: 139

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08815
Location:1045 – 1092
Blast Score: 211

Nuc_rec_co-act; Nuclear receptor coactivator

pfam07469
Location:1290 – 1345
Blast Score: 128

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:616 – 704
Blast Score: 179

SRC-1; Steroid receptor coactivator

cl00081
Location:34 – 88
Blast Score: 122

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001174088.1 → NP_001167559.1 nuclear receptor coactivator 3 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.

Source sequence(s)

AF036892, AL034418, DB091786

Consensus CDS

CCDS54472.1

UniProtKB/Swiss-Prot

Q9Y6Q9

Related

ENSP00000361065, OTTHUMP00000031717, ENST00000371997, OTTHUMT00000080404

Conserved Domains (5) summary

cd00130
Location:121 – 186
Blast Score: 139

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08815
Location:1040 – 1087
Blast Score: 211

Nuc_rec_co-act; Nuclear receptor coactivator

pfam07469
Location:1282 – 1337
Blast Score: 128

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:626 – 714
Blast Score: 179

SRC-1; Steroid receptor coactivator

cl00081
Location:34 – 88
Blast Score: 122

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_006534.3 → NP_006525.2 nuclear receptor coactivator 3 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.

Source sequence(s)

AF012108, AL034418, DB091786

Consensus CDS

CCDS13406.1

UniProtKB/Swiss-Prot

Q9Y6Q9

Related

ENSP00000345671, ENST00000340189

Conserved Domains (5) summary

cd00130
Location:121 – 186
Blast Score: 139

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08815
Location:1045 – 1092
Blast Score: 211

Nuc_rec_co-act; Nuclear receptor coactivator

pfam07469
Location:1287 – 1342
Blast Score: 128

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:616 – 704
Blast Score: 179

SRC-1; Steroid receptor coactivator

cl00081
Location:34 – 88
Blast Score: 122

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_181659.2 → NP_858045.1 nuclear receptor coactivator 3 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AF016031, AL034418, DB091786

Consensus CDS

CCDS13407.1

UniProtKB/Swiss-Prot

Q9Y6Q9

Related

ENSP00000361066, OTTHUMP00000031718, ENST00000371998, OTTHUMT00000080405

Conserved Domains (5) summary

cd00130
Location:121 – 186
Blast Score: 139

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08815
Location:1045 – 1092
Blast Score: 211

Nuc_rec_co-act; Nuclear receptor coactivator

pfam07469
Location:1291 – 1346
Blast Score: 127

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:616 – 704
Blast Score: 179

SRC-1; Steroid receptor coactivator

cl00081
Location:34 – 88
Blast Score: 122

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

46130601..46285621

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

42872332..43026949

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL021394.10 (114..68588)	None
genomic	AL034418.5	CAB40662.1
		CAC17693.1
		CAI42141.1
genomic	AL034418.5	CAB40662.1
		CAC17693.1
		CAI42141.1
genomic	AL353777.18 (49073..62824)	None
genomic	CH471077.2	EAW75696.1
		EAW75697.1
		EAW75698.1
		EAW75699.1
		EAW75700.1
		EAW75701.1
		EAW75702.1
genomic	EF488684.1	ABO43042.1
mRNA	AB209863.1	BAD93100.1
mRNA	AF010227.1	AAC51663.1
mRNA	AF012108.1	AAC51677.1
mRNA	AF016031.1	AAC51849.1
mRNA	AF036892.1	AAB92368.1
mRNA	AK289683.1	BAF82372.1
mRNA	AK296810.1	BAG59383.1
mRNA	AK302588.1	BAG63841.1
mRNA	AK302595.1	BAG63847.1
mRNA	AK308346.1	None
mRNA	BC092516.1	AAH92516.1
mRNA	BC119001.1	AAI19002.1
mRNA	BC122547.1	AAI22548.1
mRNA	BM692321.1	None
mRNA	BU588121.1	None
mRNA	CA450268.1	None
mRNA	DB091786.1	None

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
Q0IIN7	GenPept	UniProtKB/TrEMBL:Q0IIN7
Q569F6	GenPept	UniProtKB/TrEMBL:Q569F6
Q59EE8	GenPept	UniProtKB/TrEMBL:Q59EE8
Q9Y6Q9.1	GenPept	UniProtKB/Swiss-Prot:Q9Y6Q9