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CAMP cathelicidin antimicrobial peptide [ Homo sapiens (human) ]

Gene ID: 820, updated on 22-May-2016
Official Symbol
CAMPprovided by HGNC
Official Full Name
cathelicidin antimicrobial peptideprovided by HGNC
Primary source
HGNC:HGNC:1472
See related
Ensembl:ENSG00000164047 HPRD:02722; MIM:600474; Vega:OTTHUMG00000133526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39
Summary
This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
Orthologs
Location:
3p21.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (48223347..48225491)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48264837..48266981)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cell division cycle 25A Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 1 Neighboring gene microRNA 4443 Neighboring gene zinc finger protein 589 Neighboring gene mitochondrial ribosomal protein S18A pseudogene 1 Neighboring gene uncharacterized LOC105377076

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of cathelicidin antimicrobial peptide (CAMP) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • ROS, RNS production in response to bacteria, organism-specific biosystem (from REACTOME)
    ROS, RNS production in response to bacteria, organism-specific biosystemWhen engulfed by macrophages, microorganisms are exposed to a number of host defense mechanisms within the resulting phagosome and through its subsequent fusion with lysosomes. These include the prod...
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell wall TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
specific granule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cathelicidin antimicrobial peptide
Names
18 kDa cationic antimicrobial protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004345.4NP_004336.3  cathelicidin antimicrobial peptide preproprotein

    See identical proteins and their annotated locations for NP_004336.3

    Status: REVIEWED

    Source sequence(s)
    AA635187, BC055089, BU074012
    Consensus CDS
    CCDS2762.2
    UniProtKB/Swiss-Prot
    P49913
    UniProtKB/TrEMBL
    J3KNB4
    Related
    ENSP00000296435, OTTHUMP00000164805, ENST00000296435, OTTHUMT00000257501
    Conserved Domains (2) summary
    pfam00666
    Location:35101
    Cathelicidins; Cathelicidin
    pfam12153
    Location:139166
    CAP18_C; LPS binding domain of CAP18 (C terminal)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    48223347..48225491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    48217141..48219285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)