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PAS_chr2-2_0302 Multifunctional enzyme of the folic acid biosynthesis pathway [ Komagataella phaffii GS115 ]

Gene ID: 8198202, updated on 23-Nov-2023

Summary

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Gene symbol
PAS_chr2-2_0302
Gene description
Multifunctional enzyme of the folic acid biosynthesis pathway
Locus tag
PAS_chr2-2_0302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Komagataella phaffii GS115 (strain: GS115)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella
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Genomic context

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See PAS_chr2-2_0302 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
1
Sequence:
Chromosome: 2; NC_012964.1 (1809739..1812066)

Chromosome 2 - NC_012964.1Genomic Context describing neighboring genes Neighboring gene Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p Neighboring gene Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis Neighboring gene uncharacterized protein Neighboring gene Hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_012964.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the recombinant protein production host Pichia pastoris. De Schutter K, et al. Nat Biotechnol, 2009 Jun. PMID 19465926

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dihydroneopterin aldolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dihydropteroate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial envelope IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Multifunctional enzyme of the folic acid biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012964.1 Reference assembly

    Range
    1809739..1812066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002491840.1 → XP_002491885.1  Multifunctional enzyme of the folic acid biosynthesis pathway [Komagataella phaffii GS115]

    See identical proteins and their annotated locations for XP_002491885.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    C4R281, F2QRI6
    Conserved Domains (4) summary
    cd00739
    Location:479 → 766
    DHPS; DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and ...
    pfam01288
    Location:290 → 418
    HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
    pfam02152
    Location:147 → 243
    FolB; Dihydroneopterin aldolase
    cl00263
    Location:10 → 130
    TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...
Nucleotide Protein
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