SLIRP SRA stem-loop interacting RNA binding protein [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: SLIRPprovided by HGNC
Official Full Name: SRA stem-loop interacting RNA binding proteinprovided by HGNC
Primary source: HGNC:20495
Locus tag: DC23
See related: Ensembl:ENSG00000119705; HPRD:12639; MIM:610211; Vega:OTTHUMG00000171526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DC50; PD04872; C14orf156
Summary: Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]

Help top of page

Genomic context

Location :: 14q24.3

Sequence :: Chromosome: 14; NC_000014.8 (78174425..78183941)

See SLIRP in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
LRPPRC exists in a high-molecular-weight complex, and it coimmunoprecipitates with SLIRP, a stem-loop RNA-binding protein.
Title: LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria.
SLIRP plays an essential role in maintaining mitochondrial-localized mRNA transcripts that encode OxPhos protein subunits.
Title: A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis.
Our data demonstrate that SLIRP modulates NR transactivation, suggest it may regulate mitochondrial function, and provide mechanistic insight into interactions between SRA, SLIRP, SRC-1, and NCoR.
Title: SLIRP, a small SRA binding protein, is a nuclear receptor corepressor.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:123624	BioGRID:118855	BABAM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123624	BioGRID:109622	ICT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123624	BioGRID:122479	SLX1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123624	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
RNA binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: SRA stem-loop-interacting RNA-binding protein, mitochondrial

Names: SRA stem-loop-interacting RNA-binding protein, mitochondrial

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031210.4 → NP_112487.1 SRA stem-loop-interacting RNA-binding protein, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AF271779, BQ083727, EL951262

Consensus CDS

CCDS9866.1

UniProtKB/Swiss-Prot

Q9GZT3

Related

ENSP00000450909, OTTHUMP00000246303, ENST00000557342, OTTHUMT00000413901

Conserved Domains (1) summary

cd00590
Location:22 – 91
Blast Score: 154

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

78174425..78183941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

58340416..58349918

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC008044.4 (100254..102032)	None
genomic	AC008372.6 (980..8707)	None
genomic	CH471061.1	EAW81303.1
		EAW81304.1
mRNA	AF253980.1	AAG44629.1
mRNA	AF271779.1	AAG44790.1
mRNA	AJ272055.1	CAC81241.1
mRNA	AY860853.1	AAX58600.1
mRNA	BC017895.1	AAH17895.1
mRNA	BQ083727.1	None
mRNA	EL951262.1	None
other-genetic	HQ257938.1	ADR82692.1