ERS1 ethylene response sensor 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ERS1
Gene description: ethylene response sensor 1
Primary source: Araport:AT2G40940
Locus tag: AT2G40940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ERS; ETHYLENE RESPONSE SENSOR; ethylene response sensor 1; T20B5.14; T20B5_14
Summary: Ethylene receptor, subfamily 1. Has histidine kinase activity.
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Genomic context

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See ERS1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (17084321..17087326, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERS1-regulated expression of a subset of ethylene-responsive genes is related to controlling the magnitude of ethylene response.
Title: Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis.
Galpha mediates ethylene-induced stomatal closure via H2O2 production, and acts downstream of RAN1, ETR1, ERS1, EIN4 and CTR1 and upstream of EIN2, EIN3 and ARR2. The data also show that ETR1 and ERS1 mediate both ethylene and H2O2 signalling in guard cells.
Title: Heterotrimeric G protein mediates ethylene-induced stomatal closure via hydrogen peroxide synthesis in Arabidopsis.
The repression of ethylene responses by ers1 is primarily dependent on ETR1 and EIN4.
Title: Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes.
ERS1 has dual functions in the regulation of ethylene responses.
Title: Genetic and transformation studies reveal negative regulation of ERS1 ethylene receptor signaling in Arabidopsis.
AtTRP1 interacted with the ERS1 and affects cross-talk between ethylene and auxin signalling.
Title: AtTRP1 encodes a novel TPR protein that interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis.
Analysis of the double mutant null for both ETR1 and ERS1 in A. thaliana uncovered novel roles for the receptors not previously characterized.
Title: A strong constitutive ethylene-response phenotype conferred on Arabidopsis plants containing null mutations in the ethylene receptors ETR1 and ERS1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_129658.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ethylene binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein histidine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ethylene response sensor 1

NP_181626.1

ethylene response sensor 1 (ERS1); FUNCTIONS IN: ethylene binding, protein histidine kinase activity, receptor activity; INVOLVED IN: negative regulation of ethylene mediated signaling pathway; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), Signal transduction histidine kinase, core (InterPro:IPR005467), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), ATPase-like, ATP-binding domain (InterPro:IPR003594), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358), GAF (InterPro:IPR003018); BEST Arabidopsis thaliana protein match is: Signal transduction histidine kinase, hybrid-type, ethylene sensor (TAIR:AT1G66340.1); Has 78353 Blast hits to 77870 proteins in 2969 species: Archae - 539; Bacteria - 69363; Metazoa - 12; Fungi - 1128; Plants - 1692; Viruses - 20; Other Eukaryotes - 5599 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

17084321..17087326 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129658.4 → NP_181626.1 ethylene response sensor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181626.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38846

UniProtKB/TrEMBL

A0A178VNM3, A0A5S9X5X8

Conserved Domains (2) summary

PRK11107
Location:292 → 606

PRK11107; hybrid sensory histidine kinase BarA; Provisional

pfam01590
Location:158 → 307

GAF; GAF domain