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    CAMK2G calcium/calmodulin-dependent protein kinase II gamma [ Homo sapiens ]

    Gene ID: 818, updated on 19-May-2012
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    Summary

    Official Symbol
    CAMK2Gprovided by HGNC
    Official Full Name
    calcium/calmodulin-dependent protein kinase II gammaprovided by HGNC
    Primary source
    HGNC:1463
    Locus tag
    RP11-574K11.6
    See related
    Ensembl:ENSG00000148660; HPRD:03672; MIM:602123; Vega:OTTHUMG00000018492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAMK; CAMKG; CAMK-II; FLJ16043; MGC26678
    Summary
    The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
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    Genomic context

    Location :
    10q22
    Sequence :
    Chromosome: 10; NC_000010.10 (75572259..75634349, complement)
    See CAMK2G in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507331 Neighboring gene KIAA0913 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Neighboring gene chromosome 10 open reading frame 55 Neighboring gene plasminogen activator, urokinase Neighboring gene vinculin

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding. Cuddapah VA, et al. Am J Physiol Cell Physiol, 2012 Feb. PMID 22049206.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB. Oruganti SR, et al. Mol Immunol, 2011 Jul. PMID 21513986.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Non-selective cation channel-mediated Ca2+-entry and activation of Ca2+/calmodulin-dependent kinase II contribute to G2/M cell cycle arrest and survival of irradiated leukemia cells. Heise N, et al. Cell Physiol Biochem, 2010. PMID 21063097.

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. study demonstrates that premitotic condensation involves the activation of ClC-3 by Ca(2+)/calmodulin-dependent protein kinase II in glioma cells
      Title: Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding.
    2. study shows CaMKII is recruited to the immunological synapse where it interacts with and phosphorylates Bcl10; propose a mechanism whereby Ca(2+) signals can be integrated at the immunological synapse through CaMKII-dependent phosphorylation of Bcl10
      Title: CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB.
    3. Ca(2+)/calmodulin-dependent kinase II participate in control of cell cycle progression and survival of irradiated CML cells.
      Title: Non-selective cation channel-mediated Ca2+-entry and activation of Ca2+/calmodulin-dependent kinase II contribute to G2/M cell cycle arrest and survival of irradiated leukemia cells.
    4. These results indicated that PP6 and CaMKII regulated apoptosis by controlling the expression level of p27.
      Title: CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells.
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    6. The interaction between CaMKII and its binding proteins was altered by the phosphorylation state of both the CaMKII and the partner.
      Title: Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function.
    7. CaMKII is a molecular link translating intracellular calcium changes, which are intrinsically associated with glioma migration, to changes in ClC-3 conductance required for cell movement
      Title: Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma.
    8. Our results suggest a first observation that CaMKII regulates TRAIL-mediated apoptosis of fibroblast-like synovial cells through Akt, standing an upstream of caspase-8-dependent cascades.
      Title: Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.
    9. Study further supports self-aggregation of CaMKII holoenzymes as the underlying mechanism that involves inter-holoenzyme T286-region/T-site interaction.
      Title: Differential regulation by ATP versus ADP further links CaMKII aggregation to ischemic conditions.
    10. These data demonstrate that alphaKAP exhibits a novel interaction with SERCA2a and may serve to spatially position CaMKII isoforms at the SR and to uniquely modulate the phosphorylation of PLN.
      Title: Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.
    Submit: New GeneRIF Correction See all (24)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13555 P35609 ACTN2    HPRD  PubMed  
    Q13555 O43707 ACTN4    HPRD  PubMed  
    Q13555 O60266 ADCY3    HPRD  PubMed  
    Q13555 P18846 ATF1    HPRD  PubMed  
    Q13555 Q9NPB3 CABP2    HPRD  PubMed  
    Q13555 Calmodulin 1 CALM1    HPRD  PubMed  
    Q13555 Q13555 CAMK2G    HPRD  PubMed  
    Q13555 P28329 CHAT    HPRD  PubMed  
    Q13555 Q03060 CREM    HPRD  PubMed  
    Q13555 P00533 EGFR    HPRD  PubMed  
    Q13555 P21333 FLNA    HPRD  PubMed  
    Q13555 P42261 GRIA1    HPRD  PubMed  
    Q13555 P48058 GRIA4    HPRD  PubMed  
    Q13555 Q13224 GRIN2B    HPRD  PubMed  
    Q13555 Q96NW7 LRRC7    HPRD  PubMed  
    Q13555 Q15746 MYLK    HPRD  PubMed  
    Q13555 Q15121 PEA15    HPRD  PubMed  
    Q13555 Q01970 PLCB3    HPRD  PubMed  
    Q13555 P55042 RRAD    HPRD  PubMed  
    Q13555 P21817 RYR1    HPRD  PubMed  
    Q13555 P84022 SMAD3    HPRD  PubMed  
    Q13555 Q13485 SMAD4    HPRD  PubMed  
    Q13555 P35270 SPR    HPRD  PubMed  
    Q13555 P42224 STAT1    HPRD  PubMed  
    Q13555 P17600 SYN1    HPRD  PubMed  
    Q13555 P07101 TH    HPRD  PubMed  
    Q13555 Q13009 TIAM1    HPRD  PubMed  
    BioGRID:107268 BioGRID:114429 BCL10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107268 BioGRID:107252 CALM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107268 BioGRID:250730 Lrrc7    BioGRID  PubMed Two-hybrid 
    BioGRID:107268 BioGRID:116098 MALT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107268 BioGRID:117406 RCHY1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107268 BioGRID:112150 RRAD    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107268 BioGRID:110262 SMAD2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107268 BioGRID:110264 SMAD4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107268 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107268 BioGRID:116078 USP19    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
      Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • CREB phosphorylation through the activation of CaMKII, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of CaMKII, organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-in...
    • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cholinergic synapse, organism-specific biosystem (from KEGG)
      Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Gastric acid secretion, organism-specific biosystem (from KEGG)
      Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastric acid secretion, conserved biosystem (from KEGG)
      Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
      Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Olfactory transduction, organism-specific biosystem (from KEGG)
      Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Olfactory transduction, conserved biosystem (from KEGG)
      Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
      Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystem (from REACTOME)
      Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to the activation of Ras kinase via the activation of RasGRF.
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
      Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		  
    calcium-dependent protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    insulin secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    regulation of calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of skeletal muscle adaptation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    calcium- and calmodulin-dependent protein kinase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit gamma
    Names
    calcium/calmodulin-dependent protein kinase type II subunit gamma
    caMK-II subunit gamma
    calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
    NP_001191421.1
    NP_001213.2
    NP_751909.1
    NP_751910.1
    NP_751911.1
    NP_751913.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029408.1 RefSeqGene

      Range
      5001..67091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204492.1 → NP_001191421.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an alternate in-frame exon and lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 7) is shorter and lacks two internal segments compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896
      Conserved Domains (3) summary
      cd05123
      Location:20 – 271
      Blast Score: 604
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:14 – 272
      Blast Score: 846
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:407 – 534
      Blast Score: 570
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    2. NM_001222.3 → NP_001213.2  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896, L07043
      Consensus CDS
      CCDS7336.1
      UniProtKB/Swiss-Prot
      Q13555
      Related
      ENSP00000277853, OTTHUMP00000019844, ENST00000351293, OTTHUMT00000048715
      Conserved Domains (3) summary
      cd05123
      Location:20 – 271
      Blast Score: 600
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:14 – 272
      Blast Score: 840
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:363 – 490
      Blast Score: 568
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    3. NM_172169.2 → NP_751909.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, BC034044
      Consensus CDS
      CCDS7337.1
      UniProtKB/Swiss-Prot
      Q13555
      Related
      ENSP00000315599, OTTHUMP00000019843, ENST00000322635, OTTHUMT00000048714
      Conserved Domains (3) summary
      cd05123
      Location:20 – 271
      Blast Score: 599
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:14 – 272
      Blast Score: 838
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:395 – 522
      Blast Score: 566
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    4. NM_172170.4 → NP_751910.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896
      Related
      ENSP00000307082, OTTHUMP00000019847, ENST00000305762, OTTHUMT00000048718
      Conserved Domains (3) summary
      cd05123
      Location:20 – 271
      Blast Score: 604
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:14 – 272
      Blast Score: 846
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:386 – 513
      Blast Score: 571
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    5. NM_172171.2 → NP_751911.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896, U66063
      Consensus CDS
      CCDS7338.1
      UniProtKB/TrEMBL
      Q13280
      Related
      ENSP00000319060, ENST00000322680
      Conserved Domains (3) summary
      cd05123
      Location:20 – 271
      Blast Score: 609
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:14 – 272
      Blast Score: 855
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:424 – 551
      Blast Score: 574
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    6. NM_172173.2 → NP_751913.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896, U50360
      UniProtKB/Swiss-Prot
      Q13555
      Conserved Domains (3) summary
      cd05123
      Location:20 – 271
      Blast Score: 602
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:14 – 272
      Blast Score: 842
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09109
      Location:372 – 499
      Blast Score: 569
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      75572259..75634349, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      69567318..69629331, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172172.1: Suppressed sequence

      Description
      NM_172172.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC022400.9 (145210..183796) None
    genomic AL596247.22 CAI13964.1
      CAI13965.1
      CAI13966.1
      CAI13967.1
      CAI13968.1
    genomic AL713896.9 CAI13787.1
      CAI13788.1
      CAI13789.1
      CAI13790.1
      CAI13791.1
    genomic CH471083.1 EAW54527.1
      EAW54528.1
      EAW54529.1
      EAW54530.1
      EAW54531.1
      EAW54532.1
      EAW54533.1
      EAW54534.1
      EAW54535.1
      EAW54536.1
      EAW54537.1
      EAW54538.1
      EAW54539.1
      EAW54540.1
      EAW54541.1
      EAW54542.1
      EAW54543.1
    mRNA AB209474.1 BAD92711.1
    mRNA AK026309.1 None
    mRNA AK094774.1 None
    mRNA AK095576.1 BAG53089.1
    mRNA AK131199.1 BAG54748.1
    mRNA AK225771.1 None
    mRNA AK291704.1 BAF84393.1
    mRNA AK301180.1 BAG62765.1
    mRNA BC012795.2 None
    mRNA BC021269.2 AAH21269.2
    mRNA BC034044.1 AAH34044.1
    mRNA BC037928.1 None
    mRNA BU165166.1 None
    mRNA L07043.1 AAB61379.1
    mRNA L07044.1 None
    mRNA U32472.1 AAA75201.1
    mRNA U32473.1 AAA75202.1
    mRNA U32509.1 AAA75203.1
    mRNA U50359.1 AAB16864.1
    mRNA U50360.1 AAB16865.1
    mRNA U66063.1 AAB80847.1
    mRNA U66064.1 AAB80848.1
    other-genetic DQ892365.2 ABM83291.1
    other-genetic DQ895574.2 ABM86500.1
    other-genetic DQ896692.2 ABM87691.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13280 GenPept UniProtKB/TrEMBL:Q13280
    Q13555.3 GenPept UniProtKB/Swiss-Prot:Q13555
    Q59FI6 GenPept UniProtKB/TrEMBL:Q59FI6
    Q5SWX3 GenPept UniProtKB/TrEMBL:Q5SWX3
    Q8WU40 GenPept UniProtKB/TrEMBL:Q8WU40
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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