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ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 [ Homo sapiens (human) ]

Gene ID: 81794, updated on 26-Jun-2015
Official Symbol
ADAMTS10provided by HGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 10provided by HGNC
Primary source
HGNC:HGNC:13201
See related
Ensembl:ENSG00000142303; HPRD:07470; MIM:608990; Vega:OTTHUMG00000182216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WMS; WMS1; ADAM-TS10; ADAMTS-10
Summary
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
Orthologs
See ADAMTS10 in Epigenomics, MapViewer
Location:
19p13.2
Exon count:
26
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (8580240..8610753, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8645124..8675588, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 414 Neighboring gene myosin IF Neighboring gene nuclear factor interleukin-3-regulated protein-like Neighboring gene actin-like 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Weill-Marchesani syndrome 1
MedGen: C1869114 OMIM: 277600 GeneReviews: Weill-Marchesani Syndrome
Compare labs

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
  • Streptomycin biosynthesis, organism-specific biosystem (from KEGG)
    Streptomycin biosynthesis, organism-specific biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, organism-specific biosystem (from KEGG)
    Streptomycin biosynthesis, organism-specific biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, organism-specific biosystem (from KEGG)
    Streptomycin biosynthesis, organism-specific biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
  • Streptomycin biosynthesis, organism-specific biosystem (from KEGG)
    Streptomycin biosynthesis, organism-specific biosystemStreptomycin is an aminocyclitol-aminoglycoside antibiotic produced by Streptomyces griseus. Streptomycin consists of aminocyclitol (streptidine), 6-deoxyhexose (streptose), and N-methyl-L-glucosamin...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
microfibril IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 10
Names
A disintegrin and metalloproteinase with thrombospondin motifs 10
ADAM-TS 10
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
zinc metalloendopeptidase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011840.2 RefSeqGene

    Range
    4968..35463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282352.1NP_001269281.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons, uses an alternate 5'-terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130469, AF163762, AK131414, BC029308, BF510205
    Consensus CDS
    CCDS62529.1
    UniProtKB/TrEMBL
    Q6ZN14
    UniProtKB/Swiss-Prot
    Q9H324
    Related
    ENSP00000470501, OTTHUMP00000268827, ENST00000595838, OTTHUMT00000460202
    Conserved Domains (3) summary
    smart00209
    Location:497541
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:193305
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:555587
    PLAC; PLAC (protease and lacunin) domain
  2. NM_030957.3NP_112219.3  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209515, AC130469, AF163762, AK131414, BC029308, BF510205, CN431169
    Consensus CDS
    CCDS12206.1
    UniProtKB/TrEMBL
    A0A0A0MQW6
    UniProtKB/TrEMBL
    Q59FE5
    UniProtKB/TrEMBL
    Q6ZN14
    UniProtKB/Swiss-Prot
    Q9H324
    Related
    ENSP00000471851, OTTHUMP00000268655, ENST00000597188, OTTHUMT00000460085
    Conserved Domains (6) summary
    smart00209
    Location:550602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:239457
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:39180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10681100
    PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    8580240..8610753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722917.2XP_006722980.1  

    Conserved Domains (4) summary
    smart00209
    Location:182234
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:338450
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:749781
    PLAC; PLAC (protease and lacunin) domain
    cl00064
    Location:186
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. XM_011528333.1XP_011526635.1  

    See identical proteins and their annotated locations for XP_011526635.1

    Conserved Domains (6) summary
    smart00209
    Location:550602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:239457
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:39180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:11171149
    PLAC; PLAC (protease and lacunin) domain
  3. XM_011528334.1XP_011526636.1  

    Conserved Domains (6) summary
    smart00209
    Location:550602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:239457
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:39180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10091041
    PLAC; PLAC (protease and lacunin) domain
  4. XM_011528331.1XP_011526633.1  

    See identical proteins and their annotated locations for XP_011526633.1

    Conserved Domains (6) summary
    smart00209
    Location:550602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:239457
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:39180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:11171149
    PLAC; PLAC (protease and lacunin) domain
  5. XM_011528332.1XP_011526634.1  

    See identical proteins and their annotated locations for XP_011526634.1

    Conserved Domains (6) summary
    smart00209
    Location:550602
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:239454
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:239457
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:39180
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706818
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:11171149
    PLAC; PLAC (protease and lacunin) domain
  6. XM_011528335.1XP_011526637.1  

    Conserved Domains (3) summary
    smart00209
    Location:73125
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:229341
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:640672
    PLAC; PLAC (protease and lacunin) domain
  7. XM_011528336.1XP_011526638.1  

    Conserved Domains (3) summary
    smart00209
    Location:71123
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:227339
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:638670
    PLAC; PLAC (protease and lacunin) domain

RNA

  1. XR_936208.1 RNA Sequence

  2. XR_430156.2 RNA Sequence

  3. XR_936209.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    8644795..8675309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)