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TLR10 toll like receptor 10 [ Homo sapiens (human) ]

Gene ID: 81793, updated on 7-May-2016
Official Symbol
TLR10provided by HGNC
Official Full Name
toll like receptor 10provided by HGNC
Primary source
HGNC:HGNC:15634
See related
Ensembl:ENSG00000174123 HPRD:05884; MIM:606270; Vega:OTTHUMG00000128578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD290
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Orthologs
Location:
4p14
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (38772238..38782990, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38773860..38784611, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374412 Neighboring gene RNA, 5S ribosomal pseudogene 158 Neighboring gene toll like receptor 1 Neighboring gene toll like receptor 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Identification of genetic loci associated with Helicobacter pylori serologic status.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
NHGRI GWA Catalog
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with the TLR signaling cascade, organism-specific biosystem (from REACTOME)
    Diseases associated with the TLR signaling cascade, organism-specific biosystemToll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derived from pathogens (pathogen-associated molecular patterns - PAMP) or damaged cells (damage-associate...
  • Diseases of Immune System, organism-specific biosystem (from REACTOME)
    Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
  • IRAK4 deficiency (TLR5), organism-specific biosystem (from REACTOME)
    IRAK4 deficiency (TLR5), organism-specific biosystemToll like receptor 5 (TLR5) specifically recognizes bacterial infection through binding of flagellin from pathogenic bacteria. Upon ligand binding, TLR5 dimers recruit MyD88 through their TIR domains...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC104967, MGC126398, MGC126399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 10 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017388.2NP_001017388.1  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_001017388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AY358300, DA643313
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000354459, ENST00000361424
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:348455
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_001195106.1NP_001182035.1  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_001182035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one exon in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AW504309, AY358300, DA213264, DA643313
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000478206, ENST00000613579
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:348455
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_001195107.1NP_001182036.1  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_001182036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks one exon in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AF296673, AY358300, DA312129, DA643313
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000478985, ENST00000622002
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:348455
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
  4. NM_001195108.1NP_001182037.1  toll-like receptor 10 isoform b

    See identical proteins and their annotated locations for NP_001182037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' UTR and uses a different splice site which results in part of the 5' coding region being absent, compared to variant 1. The resulting predicted protein (isoform b) has a shorter N-terminus and is missing a potential signal peptide when it is compared to isoform a.
    Source sequence(s)
    AF296673, AY358300, BP383038, DA643313
    UniProtKB/Swiss-Prot
    Q9BXR5
    Conserved Domains (6) summary
    smart00082
    Location:508560
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:619761
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:334441
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:58115
    LRR_8; Leucine rich repeat
    sd00031
    Location:3659
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:336359
    LRR_RI; leucine-rich repeat [structural motif]
  5. NM_030956.3NP_112218.2  toll-like receptor 10 isoform a

    See identical proteins and their annotated locations for NP_112218.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein (isoform a).
    Source sequence(s)
    AF296673, AY358300, DA643313, DB226380
    Consensus CDS
    CCDS3445.1
    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Related
    ENSP00000308925, OTTHUMP00000158729, ENST00000308973, OTTHUMT00000250430
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:348455
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    38772238..38782990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513761.1XP_011512063.1  

    See identical proteins and their annotated locations for XP_011512063.1

    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:348455
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_011513760.1XP_011512062.1  

    See identical proteins and their annotated locations for XP_011512062.1

    Conserved Domains (6) summary
    smart00082
    Location:508560
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:619761
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:334441
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:58115
    LRR_8; Leucine rich repeat
    sd00031
    Location:3659
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:336359
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_011513762.1XP_011512064.1  

    See identical proteins and their annotated locations for XP_011512064.1

    UniProtKB/Swiss-Prot
    Q9BXR5
    UniProtKB/TrEMBL
    A0A024R9W4
    Conserved Domains (6) summary
    smart00082
    Location:522574
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:633775
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:348455
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:72129
    LRR_8; Leucine rich repeat
    sd00031
    Location:5073
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:350373
    LRR_RI; leucine-rich repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    38773441..38784192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)