NUAK2 NUAK family, SNF1-like kinase, 2 [Homo sapiens] - Gene

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Summary

Official Symbol: NUAK2provided by HGNC
Official Full Name: NUAK family, SNF1-like kinase, 2provided by HGNC
Primary source: HGNC:29558
See related: Ensembl:ENSG00000163545; HPRD:12172; MIM:608131; Vega:OTTHUMG00000037196
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SNARK; FLJ90349; DKFZp434J037; DKFZp686F01113

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Genomic context

Location :: 1q32.1

Sequence :: Chromosome: 1; NC_000001.10 (205271191..205290883, complement)

See NUAK2 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Considers possible roles of NUAK2 in tumorigenesis in general and suggest that NUAK2 has pivotal roles in acral melanomagenesis.
Title: NUAK2: an emerging acral melanoma oncogene.
MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP (myosin phosphatase Rho-interacting protein) and the inducible kinase NUAK2
Title: An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties.
Title: AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma.
Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.
Title: Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.
Skeletal muscle SNARK expression is increased in human obesity, and in response to metabolic stressors, but not type 2 diabetes. Partial SNARK depletion failed to modify either glucose or lipid metabolism.
Title: Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.
The nuclear localizing SNARK altered transcriptome profiles and a considerable part of these alterations were canceled by the mutation of NLS, suggesting the ability of SNARK to modulate gene expression dependent on its nuclear localization.
Title: Nuclear localization of SNARK; its impact on gene expression.
EBV LMP1 upregulated the expression of SNARK; SNARK expression increased drug resistance in response to doxorubicin increased of cancer cell survival
Title: SNARK, a novel downstream molecule of EBV latent membrane protein 1, is associated with resistance to cancer cell death.
These data suggests different phosphorylation and regulation of MYPT1 activity by NUAK2.
Title: Identification of a novel substrate for TNFalpha-induced kinase NUAK2.
SNARK is an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells
Title: Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness.
This study describes the cloning and characterization of the rat SNARK homolog, mapping of the human SNARK gene to 1q32, and a potential functional role as mediator of the cellular response to metabolic stress.
Title: Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9H093	Q04771	ACVR1	HPRD	PubMed
Q9H093	Q15796	SMAD2	HPRD	PubMed
Q9H093	Q13485	SMAD4	HPRD	PubMed
Q9H093	P36897	TGFBR1	HPRD	PubMed
BioGRID:123581	BioGRID:111549	PRKAA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:123581	BioGRID:113164	UBC	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: NUAK family SNF1-like kinase 2

Names: NUAK family SNF1-like kinase 2; omphalocele kinase 2; SNF1/AMP kinase-related kinase; SNF1/AMP activated protein kinase

NP_112214.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030952.1 → NP_112214.1 NUAK family SNF1-like kinase 2

Status: PROVISIONAL

Source sequence(s)

AL136891

Consensus CDS

CCDS1453.1

UniProtKB/Swiss-Prot

Q9H093

Related

ENSP00000356125, OTTHUMP00000035319, ENST00000367157, OTTHUMT00000090390

Conserved Domains (2) summary

smart00220
Location:53 – 303
Blast Score: 848

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:53 – 297
Blast Score: 637

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

205271191..205290883, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

176436830..176456534, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC098933.2 (65094..84786)	None
genomic	CH471067.1	EAW91549.1
genomic	CQ782778.1	CAF86008.1
mRNA	AK074830.1	BAC11234.1
mRNA	AK303577.1	BAG64597.1
mRNA	AK309520.1	None
mRNA	AL136891.1	CAB66825.1
mRNA	BC017306.2	AAH17306.1
mRNA	BX537564.1	None
mRNA	CR749209.1	CAH18066.1
other-genetic	AM392904.1	CAL37782.1