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AT2G32710 Cyclin-dependent kinase inhibitor family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817831, updated on 6-Oct-2023

Summary

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Gene symbol
AT2G32710
Gene description
Cyclin-dependent kinase inhibitor family protein
Primary source
Araport:AT2G32710
Locus tag
AT2G32710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ACK2; CYCLIN-DEPENDENT KINASE INHIBITOR 2; F24L7.15; F24L7_15; ICK7; INTERACTORS OF CDC2 KINASE 7; KIP-RELATED PROTEIN 4
Summary
Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI). A member of seven KRP genes found in Arabidopsis thaliana. Negative regulator of cell division. Expressed in actively dividing cells.
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Genomic context

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Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (13873362..13876737)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene LEUNIG-like protein Neighboring gene cytochrome B5 isoform B Neighboring gene 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit Neighboring gene galactosyltransferase 13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell size controlled in plants using DNA content as an internal scale. D'Ario M, et al. Science, 2021 Jun 11. PMID 34112688
  2. Active Control of Cell Size Generates Spatial Detail during Plant Organogenesis. Serrano-Mislata A, et al. Curr Biol, 2015 Nov 16. PMID 26526374, Free PMC Article
  3. Expression of Kip-related protein 4 gene (KRP4) in response to auxin and cytokinin during growth of Arabidopsis thaliana. Cho HJ, et al. BMB Rep, 2010 Apr. PMID 20423613
  4. Analysis of the spatial expression pattern of seven Kip related proteins (KRPs) in the shoot apex of Arabidopsis thaliana. Ormenese S, et al. Ann Bot, 2004 May. PMID 15037450, Free PMC Article
  5. The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4. Singh SK, et al. J Exp Bot, 2016 Mar. PMID 26773810

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell size controlled in plants using DNA content as an internal scale.
    Title: Cell size controlled in plants using DNA content as an internal scale.
  2. kip related protein (krp) 4, 6 and 7 single, double and triple mutants of Arabidopsis thaliana, were studied to understand the role of cell cycle inhibitory proteins in leaf development.
    Title: Multiple mechanisms explain how reduced KRP expression increases leaf size of Arabidopsis thaliana.
  3. AtGLR3.6 is required for primary and lateral root development, and KRP4 functions as a downstream signaling element in Arabidopsis thaliana.
    Title: The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4.
  4. the changes in cell size caused by loss and gain of KRP4 function implicated this gene in the control of meristem cell size
    Title: Active Control of Cell Size Generates Spatial Detail during Plant Organogenesis.
  5. The expression of KRP4 was decreased after treatment with phytohormones, and that Cyclin-Dependent Kinases and D-type cyclin transcription was increased.
    Title: Expression of Kip-related protein 4 gene (KRP4) in response to auxin and cytokinin during growth of Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_128830.4
NM_179865.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cyclin binding IPI
Inferred from Physical Interaction
more info
  
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Cyclin-dependent kinase inhibitor family protein
NP_565750.1
  • Cyclin-dependent kinase inhibitor family protein; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701), Cyclin-dependent kinase inhibitor (InterPro:IPR003175); BEST Arabidopsis thaliana protein match is: inhibitor/interactor with cyclin-dependent kinase (TAIR:AT5G48820.1); Has 276 Blast hits to 276 proteins in 45 species: Archae - 0; Bacteria - 0; Metazoa - 51; Fungi - 4; Plants - 203; Viruses - 0; Other Eukaryotes - 18 (source: NCBI BLink).
NP_850196.1
  • Cyclin-dependent kinase inhibitor family protein; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); BEST Arabidopsis thaliana protein match is: inhibitor/interactor with cyclin-dependent kinase (TAIR:AT5G48820.1); Has 276 Blast hits to 276 proteins in 43 species: Archae - 0; Bacteria - 0; Metazoa - 53; Fungi - 4; Plants - 203; Viruses - 0; Other Eukaryotes - 16 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    13873362..13876737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128830.4 → NP_565750.1  Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48846, Q8GYJ3, Q94CM0, Q9FR83
    UniProtKB/TrEMBL
    A0A178VY07, A0A654EY87, B4F7P5
    Conserved Domains (1) summary
    pfam02234
    Location:244 → 284
    CDI; Cyclin-dependent kinase inhibitor

  2. NM_179865.2 → NP_850196.1  Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VVB9, A0A5S9X3B3
    Conserved Domains (1) summary
    pfam02234
    Location:241 → 281
    CDI; Cyclin-dependent kinase inhibitor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GYJ3.2

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