Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    SF3A2 splicing factor 3a, subunit 2, 66kDa [ Homo sapiens (human) ]

    Gene ID: 8175, updated on 5-May-2013
    Official Symbol
    SF3A2provided by HGNC
    Official Full Name
    splicing factor 3a, subunit 2, 66kDaprovided by HGNC
    Primary source
    HGNC:10766
    See related
    Ensembl:ENSG00000104897; HPRD:02877; MIM:600796; Vega:OTTHUMG00000180414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRP11; SAP62; PRPF11; SF3a66
    Summary
    This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]
    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (2236816..2248678)
    See SF3A2 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene DOT1-like, histone H3 methyltransferase (S. cerevisiae) Neighboring gene pleckstrin homology domain containing, family J member 1 Neighboring gene microRNA 1227 Neighboring gene microRNA 4321 Neighboring gene anti-Mullerian hormone Neighboring gene junctional sarcoplasmic reticulum protein 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    2. Dynamic protein-protein interaction wiring of the human spliceosome. Hegele A, et al. Mol Cell, 2012 Feb 24. PMID 22365833.
    3. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY, et al. Nature, 2012 Feb 8. PMID 22318606.
    4. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. Naji S, et al. Mol Cell Proteomics, 2012 Apr. PMID 22174317.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (38) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing
      Title: Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Rev, p19 rev HIV-1 Rev interacting protein, splicing factor 3a, subunit 2 (SF3A2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SF3A2 is increased by RRE PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_009096.2 NP_005868.1 SF3A1    BIND  PubMed SF3a66 interacts with SF3a120. 
    Q15428 O43719 HTATSF1    HPRD  PubMed  
    Q15428 Q9HD89 RETN    HPRD  PubMed  
    Q15428 Q15459 SF3A1    HPRD  PubMed  
    Q15428 Q9HAU4 SMURF2    HPRD  PubMed  
    BioGRID:113826 BioGRID:116634 ACIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:120419 AGGF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:106819 APBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:120397 ARGLU1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115575 BCAS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114621 BUB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:118873 C16orf80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:122473 C19orf43    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:120867 CCAR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115690 CD2BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115778 CHERP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:107573 CIRBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:121123 CTNNBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:119575 CWC15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114811 DDX23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116454 DDX42    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113826 BioGRID:115210 DDX46    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113826 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:108029 DHX15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116501 DNAJC8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114749 EFTUD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:108797 FUS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115083 HDAC9    BioGRID  PubMed Negative Genetic 
    BioGRID:113826 BioGRID:115642 HMG20B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:128670 HNRNPA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109423 HNRNPAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109431 HNRNPK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115530 HNRNPR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116281 HNRNPUL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:118149 HTATSF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113826 BioGRID:109821 ILF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:109822 ILF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:121775 KIAA1967    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:110766 NCBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116578 NCBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:117363 NIPBL    BioGRID  PubMed Co-fractionation 
    BioGRID:113826 BioGRID:123737 NRIP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:111126 PCBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:124296 PHF5A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:111370 PLRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:111412 PNN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115714 PPIE    BioGRID  PubMed Co-fractionation 
    BioGRID:113826 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:111503 PPP1R8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115393 PQBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:111537 PRCC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:118151 PRPF19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114577 PRPF3    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:117563 PRPF31    BioGRID  PubMed Co-fractionation 
    BioGRID:113826 BioGRID:120792 PRPF40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:117298 PRPF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115842 PRPF8    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:116502 PUF60    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114054 RAE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:113869 RBM10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:124416 RBM17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114952 RBM39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115480 RBM5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:118134 RBMX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:118881 SAP30BP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114546 SART1    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:117447 SEC31B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:113368 SF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115580 SF3A1    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-MS; Co-fractionation; Two-hybrid 
    BioGRID:113826 BioGRID:113826 SF3A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116146 SF3A3    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:117017 SF3B1    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:119651 SF3B14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116188 SF3B2    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:117016 SF3B3    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:115554 SF3B4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:123645 SF3B5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115574 SMNDC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:122265 SMURF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113826 BioGRID:116661 SNRNP200    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112509 SNRNP70    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112510 SNRPA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112511 SNRPA1    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113826 BioGRID:112512 SNRPB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112513 SNRPB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112515 SNRPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112516 SNRPD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112517 SNRPD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112518 SNRPD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112519 SNRPE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112520 SNRPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112521 SNRPG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:119626 SRRT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112324 SRSF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112325 SRSF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112326 SRSF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112327 SRSF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112328 SRSF5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112329 SRSF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112330 SRSF7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:114231 SRSF9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:121767 SUGP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115755 SYNCRIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:212207 Sf3a1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116120 TCERG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:113023 TPM3    BioGRID  PubMed Co-fractionation 
    BioGRID:113826 BioGRID:112332 TRA2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:115435 TRAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:113157 U2AF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116466 U2AF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116932 U2SURP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:124430 USP45    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:119702 WBP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:116363 WBP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:125858 ZC3H18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:113540 ZNF207    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113826 BioGRID:1205542 rev    BioGRID  PubMed Affinity Capture-MS 
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, U2-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, U2-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    mRNA 3'-splice site recognition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    small nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    splicing factor 3A subunit 2
    Names
    splicing factor 3A subunit 2
    SAP 62
    spliceosome associated protein 62
    spliceosome-associated protein 62
    pre-mRNA splicing factor SF3A, subunit 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007165.4 → NP_009096.2  splicing factor 3A subunit 2

      Status: REVIEWED

      Source sequence(s)
      BC004434, BC009903, BC015804, BG325385, BQ642367
      Consensus CDS
      CCDS12084.1
      UniProtKB/TrEMBL
      Q05DF2
      UniProtKB/Swiss-Prot
      Q15428
      Related
      ENSP00000221494, OTTHUMP00000264268, ENST00000221494, OTTHUMT00000451268
      Conserved Domains (3) summary
      COG5246
      Location:1 – 216
      Blast Score: 422
      PRP11; Splicing factor 3a, subunit 2 [RNA processing and modification]
      smart00451
      Location:52 – 82
      Blast Score: 101
      ZnF_U1; U1-like zinc finger
      cl10717
      Location:112 – 213
      Blast Score: 256
      CactinC_cactus; Cactus-binding C-terminus of cactin protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      2236816..2248678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      2007853..2019794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      2163693..2175661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01002714.1 (38459..50400) None
    genomic AC005263.1 AAC25613.1
    genomic AMYH01009278.1 (8840..20808) None
    genomic CH471139.2 EAW69398.1
      EAW69399.1
      EAW69400.1
      EAW69401.1
      EAW69402.1
      EAW69403.1
      EAW69404.1
    genomic L21990.1 AAA60301.1
    mRNA AK314815.1 BAG37338.1
    mRNA BC004434.1 AAH04434.1
    mRNA BC009903.2 AAH09903.1
    mRNA BC015804.1 AAH15804.1
    mRNA BG325385.1 None
    mRNA BQ642367.1 None
    other-genetic DQ896781.2 ABM87780.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15428.2 GenPept UniProtKB/Swiss-Prot:Q15428

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...