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Msh2 mutS homolog 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81709, updated on 8-May-2016
Official Symbol
Msh2provided by RGD
Official Full Name
mutS homolog 2provided by RGD
Primary source
RGD:620786
See related
Ensembl:ENSRNOG00000015796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
mismatch repair protein; may have an important role in spermatogenesis [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
Location:
6q12
Exon count:
16
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (11215951..11274916, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (21198374..21256838, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene hypothetical LOC100359644 Neighboring gene uncharacterized LOC103692554 Neighboring gene uncharacterized LOC102555012 Neighboring gene uncharacterized LOC103692555 Neighboring gene epithelial cell adhesion molecule Neighboring gene potassium two pore domain channel subfamily K member 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ADP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
MutLalpha complex binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to MutLalpha complex binding ISO
Inferred from Sequence Orthology
more info
 
Y-form DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
centromeric DNA binding IEA
Inferred from Electronic Annotation
more info
 
centromeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to dinucleotide insertion or deletion binding ISO
Inferred from Sequence Orthology
more info
 
dinucleotide repeat insertion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to dinucleotide repeat insertion binding ISO
Inferred from Sequence Orthology
more info
 
double-strand/single-strand DNA junction binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
four-way junction DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
guanine/thymine mispair binding IBA
Inferred from Biological aspect of Ancestor
more info
 
guanine/thymine mispair binding IEA
Inferred from Electronic Annotation
more info
 
guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
 
heteroduplex DNA loop binding IBA
Inferred from Biological aspect of Ancestor
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
mismatched DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to mismatched DNA binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
oxidized purine DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
single base insertion or deletion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
single guanine insertion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single guanine insertion binding ISO
Inferred from Sequence Orthology
more info
 
single thymine insertion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single thymine insertion binding ISO
Inferred from Sequence Orthology
more info
 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
B cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
 
determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
germ cell development ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
NOT in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
intra-S DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
intra-S DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
isotype switching IBA
Inferred from Biological aspect of Ancestor
more info
 
isotype switching IEA
Inferred from Electronic Annotation
more info
 
isotype switching ISO
Inferred from Sequence Orthology
more info
 
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
 
maintenance of DNA repeat elements IEA
Inferred from Electronic Annotation
more info
 
maintenance of DNA repeat elements ISO
Inferred from Sequence Orthology
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
meiotic gene conversion IBA
Inferred from Biological aspect of Ancestor
more info
 
meiotic mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
mismatch repair IEA
Inferred from Electronic Annotation
more info
 
mismatch repair ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA recombination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 
oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of helicase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
 
postreplication repair IEA
Inferred from Electronic Annotation
more info
 
postreplication repair ISO
Inferred from Sequence Orthology
more info
 
postreplication repair ISS
Inferred from Sequence or Structural Similarity
more info
 
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
response to UV-B IBA
Inferred from Biological aspect of Ancestor
more info
 
response to UV-B IEA
Inferred from Electronic Annotation
more info
 
response to UV-B ISO
Inferred from Sequence Orthology
more info
 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
 
response to X-ray IEA
Inferred from Electronic Annotation
more info
 
response to X-ray ISO
Inferred from Sequence Orthology
more info
 
response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
somatic hypermutation of immunoglobulin genes IBA
Inferred from Biological aspect of Ancestor
more info
 
somatic hypermutation of immunoglobulin genes IEA
Inferred from Electronic Annotation
more info
 
somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
 
NOT somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
 
somatic recombination of immunoglobulin gene segments ISO
Inferred from Sequence Orthology
more info
 
somatic recombination of immunoglobulin genes involved in immune response ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
 
MutSalpha complex IEA
Inferred from Electronic Annotation
more info
 
MutSalpha complex ISO
Inferred from Sequence Orthology
more info
 
MutSalpha complex ISS
Inferred from Sequence or Structural Similarity
more info
 
MutSbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
 
MutSbeta complex IEA
Inferred from Electronic Annotation
more info
 
MutSbeta complex ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
nuclear chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
DNA mismatch repair protein Msh2
Names
mismatch repair protein
mutS protein homolog 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031058.1NP_112320.1  DNA mismatch repair protein Msh2

    See identical proteins and their annotated locations for NP_112320.1

    Status: PROVISIONAL

    Source sequence(s)
    X93591
    UniProtKB/Swiss-Prot
    P54275
    Related
    ENSRNOP00000021538, ENSRNOT00000021538
    Conserved Domains (5) summary
    cd03285
    Location:633852
    ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
    COG0249
    Location:26853
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:18132
    MutS_I; MutS domain I
    pfam05188
    Location:158284
    MutS_II; MutS domain II
    pfam05192
    Location:305610
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    11215951..11274916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    6571260..6630220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)