Format

Send to:

Choose Destination

Mmp9 matrix metallopeptidase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81687, updated on 22-May-2016
Official Symbol
Mmp9provided by RGD
Official Full Name
matrix metallopeptidase 9provided by RGD
Primary source
RGD:621320
See related
Ensembl:ENSRNOG00000017539
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
metalloproteinase involved in extracellular matrix remodeling and bone resorption [RGD, Feb 2006]
Orthologs
Location:
3q42
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161413410..161421473)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (167578904..167605890)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554906 Neighboring gene PDX1 C-terminal inhibiting factor 1 Neighboring gene zinc finger protein 335 Neighboring gene solute carrier family 12 member 5 Neighboring gene nuclear receptor coactivator 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
fibronectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metalloendopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to cell-matrix adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to iron(III) ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to low-density lipoprotein particle stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 
collagen catabolic process ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
embryo implantation ISO
Inferred from Sequence Orthology
more info
 
endodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
heart development IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cation channel activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
ossification IEP
Inferred from Expression Pattern
more info
PubMed 
parturition IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEP
Inferred from Expression Pattern
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
response to high light intensity IEP
Inferred from Expression Pattern
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
skeletal system development ISO
Inferred from Sequence Orthology
more info
 
tissue remodeling IDA
Inferred from Direct Assay
more info
PubMed 
transformation of host cell by virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
matrix metalloproteinase-9
Names
92 kDa gelatinase
92 kDa type IV collagenase
92-kDa type IV collagenase
GELB
MMP-9
gelatinase B
matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
NP_112317.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031055.1NP_112317.1  matrix metalloproteinase-9 precursor

    See identical proteins and their annotated locations for NP_112317.1

    Status: PROVISIONAL

    Source sequence(s)
    U24441
    UniProtKB/Swiss-Prot
    P50282
    Related
    ENSRNOP00000023965, ENSRNOT00000023965
    Conserved Domains (6) summary
    pfam04886
    Location:475510
    PT; PT repeat
    cd00062
    Location:225272
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00094
    Location:517707
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:116445
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:116445
    Peptidase_M10; Matrixin
    pfam01471
    Location:4195
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    161413410..161421473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    152289466..152297426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)