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HXK2 hexokinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816505, updated on 4-Nov-2014
Gene symbol
HXK2
Gene description
hexokinase 2
Primary source
TAIR:AT2G19860
Locus tag
AT2G19860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA HEXOKINASE 2; ATHXK2; F6F22.11; F6F22_11; hexokinase 2; HEXOKINASE 2; HXK2
Summary
Encodes a protein with hexokinase activity (AtHXK2) and acts as a sensor for plant sugar responses.
See HXK2 in MapViewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (8570750..8574000)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene hypothetical protein Neighboring gene tRNA/rRNA methyltransferase (SpoU) family protein Neighboring gene nucleotide-diphospho-sugar transferases superfamily protein

Markers

Homology

  • Homologs of the HXK2 gene: The HXK2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
NM_001084452.1
NM_127544.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
fructokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
hexokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hexokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
hexokinase-dependent signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
sugar mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chloroplast ISM
Inferred from Sequence Model
more info
 
integral component of mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISM
Inferred from Sequence Model
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
plastid IDA
Inferred from Direct Assay
more info
PubMed 
Names
hexokinase 2
NP_001077921.1
  • hexokinase 2 (HXK2); CONTAINS InterPro DOMAIN/s: Hexokinase, N-terminal (InterPro:IPR022672), Hexokinase, conserved site (InterPro:IPR019807), Hexokinase, C-terminal (InterPro:IPR022673), Hexokinase (InterPro:IPR001312); BEST Arabidopsis thaliana protein match is: hexokinase 1 (TAIR:AT4G29130.1); Has 2393 Blast hits to 2115 proteins in 319 species: Archae - 0; Bacteria - 88; Metazoa - 1275; Fungi - 598; Plants - 290; Viruses - 0; Other Eukaryotes - 142 (source: NCBI BLink).
NP_179576.1
  • hexokinase 2 (HXK2); FUNCTIONS IN: fructokinase activity, hexokinase activity, glucokinase activity, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: mitochondrion, plastid; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Hexokinase, N-terminal (InterPro:IPR022672), Hexokinase, conserved site (InterPro:IPR019807), Hexokinase, C-terminal (InterPro:IPR022673), Hexokinase (InterPro:IPR001312); BEST Arabidopsis thaliana protein match is: hexokinase 1 (TAIR:AT4G29130.1); Has 2443 Blast hits to 2159 proteins in 323 species: Archae - 0; Bacteria - 89; Metazoa - 1303; Fungi - 623; Plants - 290; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 

    Range
    8570750..8574000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127544.2NP_179576.1  hexokinase 2 [Arabidopsis thaliana]

    See proteins identical to NP_179576.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93834
    Conserved Domains (3) summary
    cd00012
    Location:99261
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    PLN02405
    Location:1497
    PLN02405; hexokinase
    pfam03727
    Location:247487
    Hexokinase_2; Hexokinase
  2. NM_001084452.1NP_001077921.1  hexokinase 2 [Arabidopsis thaliana]

    See proteins identical to NP_001077921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8MRW9
    Conserved Domains (2) summary
    cd00012
    Location:2152
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    pfam03727
    Location:138378
    Hexokinase_2; Hexokinase